UniProtKB - A0A024RAZ2 (A0A024RAZ2_HUMAN)
Protein
Mitogen-activated protein kinase kinase kinase
Gene
MAP3K12
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 47 | Proton acceptorUniRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: InterPro
- MAP kinase kinase kinase activity Source: UniProtKB-EC
GO - Biological processi
- protein autophosphorylation Source: InterPro
Keywordsi
Molecular function | KinaseImported, Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Mitogen-activated protein kinase kinase kinaseARBA annotation (EC:2.7.11.25ARBA annotation) |
Gene namesi | Name:MAP3K12Imported ORF Names:hCG_23343Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 177 | Protein kinaseInterPro annotationAdd BLAST | 177 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 335 – 398 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 424 – 670 | DisorderedSequence analysisAdd BLAST | 247 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 230 – 278 | Sequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 542 – 589 | PolarSequence analysisAdd BLAST | 48 | |
Compositional biasi | 613 – 627 | Pro-richSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisFamily and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR017419, MAP3K12_MAP3K13 IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF038165, MAPKKK12_MAPKKK13, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024RAZ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEFCAQGQLY EVLRAGRPVT PSLLVDWSMG IAGGMNYLHL HKIIHRDLKS
60 70 80 90 100
PNMLITYDDV VKISDFGTSK ELSDKSTKMS FAGTVAWMAP EVIRNEPVSE
110 120 130 140 150
KVDIWSFGVV LWELLTGEIP YKDVDSSAII WGVGSNSLHL PVPSSCPDGF
160 170 180 190 200
KILLRQCWNS KPRNRPSFRQ ILLHLDIASA DVLSTPQETY FKSQAEWREE
210 220 230 240 250
VKLHFEKIKS EGTCLHRLEE ELVMRRREEL RHALDIREHY ERKLERANNL
260 270 280 290 300
YMELNALMLQ LELKERELLR REQALERRCP GLLKPHPSRG LLHGNTMEKL
310 320 330 340 350
IKKRNVPQKL SPHSKRPDIL KTESLLPKLD AALSGVGLPG CPKGPPSPGR
360 370 380 390 400
SRRGKTRHRK ASAKGSCGDL PGLRTAVPPH EPGGPGSPGG LGGGPSAWEA
410 420 430 440 450
CPPALRGLHH DLLLRKMSSS SPDLLSAALG SRGRGATGGA GDPGSPPPAR
460 470 480 490 500
GDTPPSEGSA PGSTSPDSPG GAKGEPPPPV GPGEGVGLLG TGREGTSGRG
510 520 530 540 550
GSRAGSQHLT PAALLYRAAV TRSQKRGISS EEEEGEVDSE VELTSSQRWP
560 570 580 590 600
QSLNMRQSLS TFSSENPSDG EEGTASEPSP SGTPEVGSTN TDERPDERSD
610 620 630 640 650
DMCSQGSEIP LDPPPSEVIP GPEPSSLPIP HQELLRERGP PNSEDSDCDS
660 670
TELDNSNSVD ALRPPASLPP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471054 Genomic DNA Translation: EAW96714.1 CH471054 Genomic DNA Translation: EAW96716.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471054 Genomic DNA Translation: EAW96714.1 CH471054 Genomic DNA Translation: EAW96716.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A024RAZ2 |
Miscellaneous databases
ChiTaRSi | MAP3K12, human |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR017419, MAP3K12_MAP3K13 IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF038165, MAPKKK12_MAPKKK13, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RAZ2_HUMAN | |
Accessioni | A0A024RAZ2Primary (citable) accession number: A0A024RAZ2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | October 7, 2020 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |