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UniProtKB - A0A024RAP4 (A0A024RAP4_HUMAN)
Protein
DNA polymerase kappa
Gene
POLK
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.7.7ARBA annotation
Cofactori
Mg2+ARBA annotation
GO - Molecular functioni
- damaged DNA binding Source: InterPro
- DNA-directed DNA polymerase activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- postreplication repair Source: UniProt
Keywordsi
Molecular function | DNA-directed DNA polymeraseARBA annotation, Mutator proteinARBA annotation, Nucleotidyltransferase, Transferase |
Biological process | DNA damage, DNA repairPROSITE-ProRule annotationARBA annotation, DNA replicationARBA annotation, DNA synthesisARBA annotation |
Ligand | MagnesiumARBA annotation, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:POLKImported ORF Names:hCG_18353Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000122008 |
Expressioni
Gene expression databases
Bgeei | ENSG00000122008, Expressed in corpus callosum and 220 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 103 – 358 | UmuCInterPro annotationAdd BLAST | 256 | |
Domaini | 621 – 651 | UBZ4-typeInterPro annotationAdd BLAST | 31 | |
Domaini | 776 – 806 | UBZ4-typeInterPro annotationAdd BLAST | 31 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 816 – 858 | DisorderedSequence analysisAdd BLAST | 43 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 57 – 77 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 79 – 99 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 425 – 445 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 820 – 838 | Polar residuesSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_012348_11_3_1 |
OMAi | ETSWHNF |
Family and domain databases
CDDi | cd03586, PolY_Pol_IV_kappa, 1 hit |
Gene3Di | 3.30.1490.100, 1 hit 3.30.70.270, 1 hit |
HAMAPi | MF_01113, DNApol_IV, 1 hit |
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR036775, DNA_pol_Y-fam_lit_finger_sf IPR017961, DNA_pol_Y-fam_little_finger IPR022880, DNApol_IV IPR024728, PolY_HhH_motif IPR006642, Rad18_UBZ4 IPR043128, Rev_trsase/Diguanyl_cyclase IPR001126, UmuC |
Pfami | View protein in Pfam PF00817, IMS, 1 hit PF11799, IMS_C, 1 hit PF11798, IMS_HHH, 1 hit |
SMARTi | View protein in SMART SM00734, ZnF_Rad18, 2 hits |
SUPFAMi | SSF100879, SSF100879, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50173, UMUC, 1 hit PS51908, ZF_UBZ4, 2 hits |
i Sequence
Sequence statusi: Complete.
A0A024RAP4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSTKEKCDS YKDDLLLRMG LNDNKAGMEG LDKEKINKII MEATKGSRFY
60 70 80 90 100
GNELKKEKQV NQRIENMMQQ KAQITSQQLR KAQLQVDRFA MELEQSRNLS
110 120 130 140 150
NTIVHIDMDA FYAAVEMRDN PELKDKPIAV GSMSMLSTSN YHARRFGVRA
160 170 180 190 200
AMPGFIAKRL CPQLIIVPPN FDKYRAVSKE VKEILADYDP NFMAMSLDEA
210 220 230 240 250
YLNITKHLEE RQNWPEDKRR YFIKMGSSVE NDNPGKEVNK LSEHERSISP
260 270 280 290 300
LLFEESPSDV QPPGDPFQVN FEEQNNPQIL QNSVVFGTSA QEVVKEIRFR
310 320 330 340 350
IEQKTTLTAS AGIAPNTMLA KVCSDKNKPN GQYQILPNRQ AVMDFIKDLP
360 370 380 390 400
IRKVSGIGKV TEKMLKALGI ITCTELYQQR ALLSLLFSET SWHYFLHISL
410 420 430 440 450
GLGSTHLTRD GERKSMSVER TFSEINKAEE QYSLCQELCS ELAQDLQKER
460 470 480 490 500
LKGRTVTIKL KNVNFEVKTR ASTVSSVVST AEEIFAIAKE LLKTEIDADF
510 520 530 540 550
PHPLRLRLMG VRISSFPNEE DRKHQQRSII GFLQAGNQAL SATECTLEKT
560 570 580 590 600
DKDKFVKPLE MSHKKSFFDK KRSERKWSHQ DTFKCEAVNK QSFQTSQPFQ
610 620 630 640 650
VLKKKMNENL EISENSDDCQ ILTCPVCFRA QGCISLEALN KHVDECLDGP
660 670 680 690 700
SISENFKMFS CSHVSATKVN KKENVPASSL CEKQDYEAHP KIKEISSVDC
710 720 730 740 750
IALVDTIDNS SKAESIDALS NKHSKEECSS LPSKSFNIEH CHQNSSSTVS
760 770 780 790 800
LENEDVGSFR QEYRQPYLCE VKTGQALVCP VCNVEQKTSD LTLFNVHVDV
810 820 830 840 850
CLNKSFIQEL RKDKFNPVNQ PKESSRSTGS SSGVQKAVTR TKRPGLMTKY
860 870
STSKKIKPNN PKHTLDIFFK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471084 Genomic DNA Translation: EAW95764.1 CH471084 Genomic DNA Translation: EAW95765.1 |
RefSeqi | NP_057302.1, NM_016218.3 XP_016865048.1, XM_017009559.1 XP_016865049.1, XM_017009560.1 |
Genome annotation databases
GeneIDi | 51426 |
KEGGi | hsa:51426 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471084 Genomic DNA Translation: EAW95764.1 CH471084 Genomic DNA Translation: EAW95765.1 |
RefSeqi | NP_057302.1, NM_016218.3 XP_016865048.1, XM_017009559.1 XP_016865049.1, XM_017009560.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 12396, 331 antibodies from 31 providers |
DNASUi | 51426 |
Genome annotation databases
GeneIDi | 51426 |
KEGGi | hsa:51426 |
Organism-specific databases
CTDi | 51426 |
VEuPathDBi | HostDB:ENSG00000122008 |
Phylogenomic databases
HOGENOMi | CLU_012348_11_3_1 |
OMAi | ETSWHNF |
Miscellaneous databases
BioGRID-ORCSi | 51426, 17 hits in 1083 CRISPR screens |
ChiTaRSi | POLK, human |
GenomeRNAii | 51426 |
Gene expression databases
Bgeei | ENSG00000122008, Expressed in corpus callosum and 220 other tissues |
Family and domain databases
CDDi | cd03586, PolY_Pol_IV_kappa, 1 hit |
Gene3Di | 3.30.1490.100, 1 hit 3.30.70.270, 1 hit |
HAMAPi | MF_01113, DNApol_IV, 1 hit |
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR036775, DNA_pol_Y-fam_lit_finger_sf IPR017961, DNA_pol_Y-fam_little_finger IPR022880, DNApol_IV IPR024728, PolY_HhH_motif IPR006642, Rad18_UBZ4 IPR043128, Rev_trsase/Diguanyl_cyclase IPR001126, UmuC |
Pfami | View protein in Pfam PF00817, IMS, 1 hit PF11799, IMS_C, 1 hit PF11798, IMS_HHH, 1 hit |
SMARTi | View protein in SMART SM00734, ZnF_Rad18, 2 hits |
SUPFAMi | SSF100879, SSF100879, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50173, UMUC, 1 hit PS51908, ZF_UBZ4, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RAP4_HUMAN | |
Accessioni | A0A024RAP4Primary (citable) accession number: A0A024RAP4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | May 25, 2022 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |