HMGCR

Functionⁱ

Catalytic activityⁱ

(R)-mevalonate + CoA + 2 NADP⁺ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.UniRule annotationSAAS annotation

Pathwayⁱ: (R)-mevalonate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

no protein annotated in this organism
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1), Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2), 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase (HMGCS1), 3-hydroxy-3-methylglutaryl coenzyme A synthase
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR)

This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functionⁱ

hydroxymethylglutaryl-CoA reductase (NADPH) activity Source: UniProtKB-EC
hydroxymethylglutaryl-CoA reductase activity Source: Ensembl
NADP binding Source: InterPro
protein homodimerization activity Source: Ensembl
protein phosphatase 2A binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
cholesterol biosynthetic process Source: Ensembl
coenzyme A metabolic process Source: InterPro
isoprenoid biosynthetic process Source: Ensembl
myoblast differentiation Source: Ensembl
negative regulation of blood vessel diameter Source: Ensembl
negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
negative regulation of MAP kinase activity Source: Ensembl
negative regulation of striated muscle cell apoptotic process Source: Ensembl
negative regulation of wound healing Source: Ensembl
positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
positive regulation of ERK1 and ERK2 cascade Source: Ensembl
positive regulation of skeletal muscle tissue development Source: Ensembl
positive regulation of smooth muscle cell proliferation Source: Ensembl
positive regulation of stress-activated MAPK cascade Source: Ensembl
response to ethanol Source: Ensembl
response to nutrient Source: Ensembl
ubiquinone metabolic process Source: Ensembl
visual learning Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	OxidoreductaseUniRule annotationSAAS annotation
Ligand	NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayⁱ	UPA00058;UER00103

UniPathwayⁱ

UPA00058;UER00103

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 3-hydroxy-3-methylglutaryl coenzyme A reductaseUniRule annotation (EC:1.1.1.34UniRule annotation) Short name: HMG-CoA reductaseUniRule annotation
Gene namesⁱ	Name:HMGCRImported ORF Names:hCG_1757337Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000113161.15

EuPathDBⁱ

HostDB:ENSG00000113161.15

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	20 – 37	HelicalUniRule annotationAdd BLAST	18
Transmembraneⁱ	57 – 78	HelicalUniRule annotationAdd BLAST	22
Transmembraneⁱ	90 – 113	HelicalUniRule annotationAdd BLAST	24
Transmembraneⁱ	157 – 182	HelicalUniRule annotationAdd BLAST	26
Transmembraneⁱ	202 – 220	HelicalUniRule annotationAdd BLAST	19

Keywords - Cellular componentⁱ

Endoplasmic reticulumUniRule annotation, Membrane

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000113161 Expressed in 227 organ(s), highest expression level in adrenal tissue

Bgeeⁱ

ENSG00000113161 Expressed in 227 organ(s), highest expression level in adrenal tissue

Interactionⁱ

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl
protein phosphatase 2A binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	61 – 218	SSDInterPro annotationAdd BLAST		158

Sequence similaritiesⁱ

Belongs to the HMG-CoA reductase family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG2480 Eukaryota COG1257 LUCA
KEGG Orthology (KO) More...KOⁱ	K00021
OMAⁱ	CASHPWE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I1B

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00643 HMG-CoA_reductase_classI, 1 hit
Gene3Dⁱ	1.10.3270.10, 1 hit 3.30.70.420, 1 hit 3.90.770.10, 1 hit
InterProⁱ	View protein in InterPro IPR002202 HMG_CoA_Rdtase IPR023074 HMG_CoA_Rdtase_cat_sf IPR023076 HMG_CoA_Rdtase_CS IPR004554 HMG_CoA_Rdtase_eu_arc IPR004816 HMG_CoA_Rdtase_metazoan IPR023282 HMG_CoA_Rdtase_N IPR009023 HMG_CoA_Rdtase_NAD(P)-bd_sf IPR009029 HMG_CoA_Rdtase_sub-bd_dom_sf IPR000731 SSD
PANTHERⁱ	PTHR10572 PTHR10572, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00368 HMG-CoA_red, 1 hit PF12349 Sterol-sensing, 1 hit
PRINTSⁱ	PR00071 HMGCOARDTASE
SUPFAMⁱ	SSF55035 SSF55035, 1 hit SSF56542 SSF56542, 1 hit
TIGRFAMsⁱ	TIGR00920 2A060605, 1 hit TIGR00533 HMG_CoA_R_NADP, 1 hit
PROSITEⁱ	View protein in PROSITE PS00066 HMG_COA_REDUCTASE_1, 1 hit PS00318 HMG_COA_REDUCTASE_2, 1 hit PS01192 HMG_COA_REDUCTASE_3, 1 hit PS50065 HMG_COA_REDUCTASE_4, 1 hit PS50156 SSD, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A024RAP2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC 
        60         70         80         90        100
PKFEEDVLSS DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI 
       110        120        130        140        150
FSSFVFSTVV IHFLDKELTG LNEALPFFLL LIDLSRASTL AKFALSSNSQ 
       160        170        180        190        200
DEVRENIARG MAILGPTFTL DALVECLVIG VGTMSGVRQL EIMCCFGCMS 
       210        220        230        240        250
VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR VLEEEENKPN 
       260        270        280        290        300
PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTADTSKVS LGLDENVSKR 
       310        320        330        340        350
IEPSVSLWQF YLSKMISMDI EQVITLSLAL LLAVKYIFFE QTETESTLSL 
       360        370        380        390        400
KNPITSPVVT QKKVPDNCCR REPMLVRNNQ KCDSVEEETG INRERKVEVI 
       410        420        430        440        450
KPLVAETDTP NRATFVVGNS SLLDTSSVLV TQEPEIELPR EPRPNEECLQ 
       460        470        480        490        500
ILGNAEKGAK FLSDAEIIQL VNAKHIPAYK LETLMETHER GVSIRRQLLS 
       510        520        530        540        550
KKLSEPSSLQ YLPYRDYNYS LVMGACCENV IGYMPIPVGV AGPLCLDEKE 
       560        570        580        590        600
FQVPMATTEG CLVASTNRGC RAIGLGGGAS SRVLADGMTR GPVVRLPRAC 
       610        620        630        640        650
DSAEVKAWLE TSEGFAVIKE AFDSTSRFAR LQKLHTSIAG RNLYIRFQSR 
       660        670        680        690        700
SGDAMGMNMI SKGTEKALSK LHEYFPEMQI LAVSGNYCTD KKPAAINWIE 
       710        720        730        740        750
GRGKSVVCEA VIPAKVVREV LKTTTEAMIE VNINKNLVGS AMAGSIGGYN 
       760        770        780        790        800
AHAANIVTAI YIACGQDAAQ NVGSSNCITL MEASGPTNED LYISCTMPSI 
       810        820        830        840        850
EIGTVGGGTN LLPQQACLQM LGVQGACKDN PGENARQLAR IVCGTVMAGE 
       860        870        880 
LSLMAALAAG HLVKSHMIHN RSKINLQDLQ GACTKKTA

Length:888

Mass (Da):97,476

Last modified:July 9, 2014 - v1

Checksum:ⁱ49B610DCCCFA26B6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471084 Genomic DNA Translation: EAW95754.1 CH471084 Genomic DNA Translation: EAW95755.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000850.1, NM_000859.2 XP_011541660.1, XM_011543358.1
UniGeneⁱ	Hs.628096 Hs.643495

Genome annotation databases

GeneIDⁱ	3156
KEGGⁱ	hsa:3156

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A024RAP2	3-hydroxy-3-methylglutaryl-coenzyme A reductase	)	HUMAN		888	UniRef100_P04035
Isoform 3 of 3-hydroxy-3-methylglutaryl-coenzyme A reductase		HUMAN		908

Protein	Similar proteins		Species	Score	Length	Source
A0A024RAP2	3-hydroxy-3-methylglutaryl-coenzyme A reductase	)	HUMAN		888	UniRef90_P04035
3-hydroxy-3-methylglutaryl-coenzyme A reductase		BOVIN		888
3-hydroxy-3-methylglutaryl-coenzyme A reductase		PONAB		888
3-hydroxy-3-methylglutaryl-coenzyme A reductase		RABIT		888
3-hydroxy-3-methylglutaryl-coenzyme A reductase		MOUSE		887
+172

Protein	Similar proteins		Species	Score	Length	Source
A0A024RAP2	3-hydroxy-3-methylglutaryl-coenzyme A reductase	)	HUMAN		888	UniRef50_P04035
3-hydroxy-3-methylglutaryl-coenzyme A reductase		PONAB		888
3-hydroxy-3-methylglutaryl-coenzyme A reductase		RABIT		888
3-hydroxy-3-methylglutaryl-coenzyme A reductase		BOVIN		888
3-hydroxy-3-methylglutaryl-coenzyme A reductase		MESAU		887
+457

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471084 Genomic DNA Translation: EAW95754.1 CH471084 Genomic DNA Translation: EAW95755.1
RefSeqⁱ	NP_000850.1, NM_000859.2 XP_011541660.1, XM_011543358.1
UniGeneⁱ	Hs.628096 Hs.643495

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	3156
KEGGⁱ	hsa:3156

Organism-specific databases

CTDⁱ	3156
EuPathDBⁱ	HostDB:ENSG00000113161.15

Phylogenomic databases

eggNOGⁱ	KOG2480 Eukaryota COG1257 LUCA
KOⁱ	K00021
OMAⁱ	CASHPWE
OrthoDBⁱ	EOG091G0I1B

Enzyme and pathway databases

UniPathwayⁱ	UPA00058;UER00103

UniPathwayⁱ

UPA00058;UER00103

Miscellaneous databases

ChiTaRSⁱ	HMGCR human
GenomeRNAiⁱ	3156

Gene expression databases

Bgeeⁱ	ENSG00000113161 Expressed in 227 organ(s), highest expression level in adrenal tissue

Bgeeⁱ

ENSG00000113161 Expressed in 227 organ(s), highest expression level in adrenal tissue

Family and domain databases

CDDⁱ	cd00643 HMG-CoA_reductase_classI, 1 hit
Gene3Dⁱ	1.10.3270.10, 1 hit 3.30.70.420, 1 hit 3.90.770.10, 1 hit
InterProⁱ	View protein in InterPro IPR002202 HMG_CoA_Rdtase IPR023074 HMG_CoA_Rdtase_cat_sf IPR023076 HMG_CoA_Rdtase_CS IPR004554 HMG_CoA_Rdtase_eu_arc IPR004816 HMG_CoA_Rdtase_metazoan IPR023282 HMG_CoA_Rdtase_N IPR009023 HMG_CoA_Rdtase_NAD(P)-bd_sf IPR009029 HMG_CoA_Rdtase_sub-bd_dom_sf IPR000731 SSD
PANTHERⁱ	PTHR10572 PTHR10572, 1 hit
Pfamⁱ	View protein in Pfam PF00368 HMG-CoA_red, 1 hit PF12349 Sterol-sensing, 1 hit
PRINTSⁱ	PR00071 HMGCOARDTASE
SUPFAMⁱ	SSF55035 SSF55035, 1 hit SSF56542 SSF56542, 1 hit
TIGRFAMsⁱ	TIGR00920 2A060605, 1 hit TIGR00533 HMG_CoA_R_NADP, 1 hit
PROSITEⁱ	View protein in PROSITE PS00066 HMG_COA_REDUCTASE_1, 1 hit PS00318 HMG_COA_REDUCTASE_2, 1 hit PS01192 HMG_COA_REDUCTASE_3, 1 hit PS50065 HMG_COA_REDUCTASE_4, 1 hit PS50156 SSD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A024RAP2_HUMAN
Accessionⁱ	A0A024RAP2Primary (citable) accession number: A0A024RAP2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 9, 2014
	Last sequence update:	July 9, 2014
	Last modified:	November 7, 2018
	This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A0A024RAP2 (A0A024RAP2_HUMAN)

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3-hydroxy-3-methylglutaryl coenzyme A reductase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: (R)-mevalonate biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Pathwayⁱ: (R)-mevalonate biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ