UniProtKB - A0A024RAP2 (A0A024RAP2_HUMAN)
Protein
3-hydroxy-3-methylglutaryl coenzyme A reductase
Gene
HMGCR
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- (R)-mevalonate + CoA + 2 NADP+ = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPHUniRule annotationEC:1.1.1.34UniRule annotation
: (R)-mevalonate biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.UniRule annotationARBA annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- no protein annotated in this organism
- 3-hydroxy-3-methylglutaryl coenzyme A synthase (HMGCS1), 3-hydroxy-3-methylglutaryl coenzyme A synthase, Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1), 3-hydroxy-3-methylglutaryl coenzyme A synthase, Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2), 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase
- 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), 3-hydroxy-3-methylglutaryl coenzyme A reductase
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.
GO - Molecular functioni
- hydroxymethylglutaryl-CoA reductase (NADPH) activity Source: UniProtKB-EC
- hydroxymethylglutaryl-CoA reductase activity Source: Ensembl
- identical protein binding Source: Ensembl
- NADP binding Source: InterPro
- protein phosphatase 2A binding Source: Ensembl
GO - Biological processi
- aging Source: Ensembl
- bile acid signaling pathway Source: Ensembl
- cholesterol biosynthetic process Source: UniProtKB-KW
- cholesterol homeostasis Source: Ensembl
- coenzyme A metabolic process Source: InterPro
- isoprenoid biosynthetic process Source: Ensembl
- myoblast differentiation Source: Ensembl
- negative regulation of amyloid-beta clearance Source: Ensembl
- negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
- negative regulation of MAP kinase activity Source: Ensembl
- negative regulation of protein catabolic process Source: Ensembl
- negative regulation of striated muscle cell apoptotic process Source: Ensembl
- negative regulation of wound healing Source: Ensembl
- positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of skeletal muscle tissue development Source: Ensembl
- positive regulation of smooth muscle cell proliferation Source: Ensembl
- positive regulation of stress-activated MAPK cascade Source: Ensembl
- response to cholesterol Source: Ensembl
- response to ethanol Source: Ensembl
- response to nutrient Source: Ensembl
- triglyceride homeostasis Source: Ensembl
- ubiquinone metabolic process Source: Ensembl
- visual learning Source: Ensembl
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Biological process | Cholesterol biosynthesisARBA annotation, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism |
Ligand | NADPUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00058;UER00103 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-hydroxy-3-methylglutaryl coenzyme A reductaseUniRule annotation (EC:1.1.1.34UniRule annotation)Short name: HMG-CoA reductaseUniRule annotation |
Gene namesi | Name:HMGCRImported ORF Names:hCG_1757337Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000113161.15 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Peroxisome
- Peroxisome membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Peroxisome
- peroxisomal membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 37 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 57 – 78 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 90 – 113 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 157 – 182 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 202 – 220 | HelicalUniRule annotationAdd BLAST | 19 |
Keywords - Cellular componenti
Endoplasmic reticulumUniRule annotationARBA annotation, Membrane, PeroxisomeARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000113161, Expressed in adrenal tissue and 237 other tissues |
ExpressionAtlasi | A0A024RAP2, baseline and differential |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- protein phosphatase 2A binding Source: Ensembl
Chemistry databases
BindingDBi | A0A024RAP2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 218 | SSDInterPro annotationAdd BLAST | 158 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
HOGENOMi | CLU_001734_0_1_1 |
OMAi | CENVLGY |
Family and domain databases
CDDi | cd00643, HMG-CoA_reductase_classI, 1 hit |
Gene3Di | 1.10.3270.10, 1 hit 3.30.70.420, 1 hit 3.90.770.10, 1 hit |
InterProi | View protein in InterPro IPR002202, HMG_CoA_Rdtase IPR023074, HMG_CoA_Rdtase_cat_sf IPR023076, HMG_CoA_Rdtase_CS IPR004554, HMG_CoA_Rdtase_eu_arc IPR004816, HMG_CoA_Rdtase_metazoan IPR023282, HMG_CoA_Rdtase_N IPR009023, HMG_CoA_Rdtase_NAD(P)-bd_sf IPR009029, HMG_CoA_Rdtase_sub-bd_dom_sf IPR000731, SSD |
PANTHERi | PTHR10572, PTHR10572, 1 hit |
Pfami | View protein in Pfam PF00368, HMG-CoA_red, 1 hit PF12349, Sterol-sensing, 1 hit |
PRINTSi | PR00071, HMGCOARDTASE |
SUPFAMi | SSF55035, SSF55035, 1 hit SSF56542, SSF56542, 1 hit |
TIGRFAMsi | TIGR00920, 2A060605, 1 hit TIGR00533, HMG_CoA_R_NADP, 1 hit |
PROSITEi | View protein in PROSITE PS00066, HMG_COA_REDUCTASE_1, 1 hit PS00318, HMG_COA_REDUCTASE_2, 1 hit PS01192, HMG_COA_REDUCTASE_3, 1 hit PS50065, HMG_COA_REDUCTASE_4, 1 hit PS50156, SSD, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024RAP2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC
60 70 80 90 100
PKFEEDVLSS DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI
110 120 130 140 150
FSSFVFSTVV IHFLDKELTG LNEALPFFLL LIDLSRASTL AKFALSSNSQ
160 170 180 190 200
DEVRENIARG MAILGPTFTL DALVECLVIG VGTMSGVRQL EIMCCFGCMS
210 220 230 240 250
VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR VLEEEENKPN
260 270 280 290 300
PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTADTSKVS LGLDENVSKR
310 320 330 340 350
IEPSVSLWQF YLSKMISMDI EQVITLSLAL LLAVKYIFFE QTETESTLSL
360 370 380 390 400
KNPITSPVVT QKKVPDNCCR REPMLVRNNQ KCDSVEEETG INRERKVEVI
410 420 430 440 450
KPLVAETDTP NRATFVVGNS SLLDTSSVLV TQEPEIELPR EPRPNEECLQ
460 470 480 490 500
ILGNAEKGAK FLSDAEIIQL VNAKHIPAYK LETLMETHER GVSIRRQLLS
510 520 530 540 550
KKLSEPSSLQ YLPYRDYNYS LVMGACCENV IGYMPIPVGV AGPLCLDEKE
560 570 580 590 600
FQVPMATTEG CLVASTNRGC RAIGLGGGAS SRVLADGMTR GPVVRLPRAC
610 620 630 640 650
DSAEVKAWLE TSEGFAVIKE AFDSTSRFAR LQKLHTSIAG RNLYIRFQSR
660 670 680 690 700
SGDAMGMNMI SKGTEKALSK LHEYFPEMQI LAVSGNYCTD KKPAAINWIE
710 720 730 740 750
GRGKSVVCEA VIPAKVVREV LKTTTEAMIE VNINKNLVGS AMAGSIGGYN
760 770 780 790 800
AHAANIVTAI YIACGQDAAQ NVGSSNCITL MEASGPTNED LYISCTMPSI
810 820 830 840 850
EIGTVGGGTN LLPQQACLQM LGVQGACKDN PGENARQLAR IVCGTVMAGE
860 870 880
LSLMAALAAG HLVKSHMIHN RSKINLQDLQ GACTKKTA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471084 Genomic DNA Translation: EAW95754.1 CH471084 Genomic DNA Translation: EAW95755.1 |
RefSeqi | NP_000850.1, NM_000859.2 XP_011541660.1, XM_011543358.1 |
Genome annotation databases
GeneIDi | 3156 |
KEGGi | hsa:3156 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471084 Genomic DNA Translation: EAW95754.1 CH471084 Genomic DNA Translation: EAW95755.1 |
RefSeqi | NP_000850.1, NM_000859.2 XP_011541660.1, XM_011543358.1 |
3D structure databases
SMRi | A0A024RAP2 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024RAP2 |
Protocols and materials databases
Antibodypediai | 24380, 339 antibodies |
DNASUi | 3156 |
Genome annotation databases
GeneIDi | 3156 |
KEGGi | hsa:3156 |
Organism-specific databases
CTDi | 3156 |
VEuPathDBi | HostDB:ENSG00000113161.15 |
Phylogenomic databases
HOGENOMi | CLU_001734_0_1_1 |
OMAi | CENVLGY |
Enzyme and pathway databases
UniPathwayi | UPA00058;UER00103 |
Miscellaneous databases
BioGRID-ORCSi | 3156, 623 hits in 996 CRISPR screens |
ChiTaRSi | HMGCR, human |
GenomeRNAii | 3156 |
Gene expression databases
Bgeei | ENSG00000113161, Expressed in adrenal tissue and 237 other tissues |
ExpressionAtlasi | A0A024RAP2, baseline and differential |
Family and domain databases
CDDi | cd00643, HMG-CoA_reductase_classI, 1 hit |
Gene3Di | 1.10.3270.10, 1 hit 3.30.70.420, 1 hit 3.90.770.10, 1 hit |
InterProi | View protein in InterPro IPR002202, HMG_CoA_Rdtase IPR023074, HMG_CoA_Rdtase_cat_sf IPR023076, HMG_CoA_Rdtase_CS IPR004554, HMG_CoA_Rdtase_eu_arc IPR004816, HMG_CoA_Rdtase_metazoan IPR023282, HMG_CoA_Rdtase_N IPR009023, HMG_CoA_Rdtase_NAD(P)-bd_sf IPR009029, HMG_CoA_Rdtase_sub-bd_dom_sf IPR000731, SSD |
PANTHERi | PTHR10572, PTHR10572, 1 hit |
Pfami | View protein in Pfam PF00368, HMG-CoA_red, 1 hit PF12349, Sterol-sensing, 1 hit |
PRINTSi | PR00071, HMGCOARDTASE |
SUPFAMi | SSF55035, SSF55035, 1 hit SSF56542, SSF56542, 1 hit |
TIGRFAMsi | TIGR00920, 2A060605, 1 hit TIGR00533, HMG_CoA_R_NADP, 1 hit |
PROSITEi | View protein in PROSITE PS00066, HMG_COA_REDUCTASE_1, 1 hit PS00318, HMG_COA_REDUCTASE_2, 1 hit PS01192, HMG_COA_REDUCTASE_3, 1 hit PS50065, HMG_COA_REDUCTASE_4, 1 hit PS50156, SSD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RAP2_HUMAN | |
Accessioni | A0A024RAP2Primary (citable) accession number: A0A024RAP2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | April 7, 2021 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |