UniProtKB - A0A024RAL7 (A0A024RAL7_HUMAN)
Protein
Submitted name:
MADS box transcription enhancer factor 2, polypeptide C (Myocyte enhancer factor 2C), isoform CRA_b
Gene
MEF2C
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: InterPro
GO - Biological processi
- nervous system development Source: UniProtKB-KW
- positive regulation of transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Biological process | NeurogenesisARBA annotation, Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: MADS box transcription enhancer factor 2, polypeptide C (Myocyte enhancer factor 2C), isoform CRA_bImported |
Gene namesi | Name:MEF2CImported ORF Names:hCG_36839Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000081189.13 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleoplasm Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000081189, Expressed in middle temporal gyrus and 241 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 61 | MADS-boxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 91 – 116 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 180 – 224 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 375 – 473 | DisorderedSequence analysisAdd BLAST | 99 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 93 – 116 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 375 – 405 | PolarSequence analysisAdd BLAST | 31 |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR022102, HJURP_C IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF12347, HJURP_C, 1 hit PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024RAL7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS
60 70 80 90 100
TNKLFQYAST DMDKVLLKYT EYNEPHESRT NSDIVETLRK KGLNGCDSPD
110 120 130 140 150
PDADDSVGHS PESEDKYRKI NEDIDLMISR QRLCAVPPPN FEMPVSIPVS
160 170 180 190 200
SHNSLVYSNP VSSLGNPNLL PLAHPSLQRN SMSPGVTHRP PSAGNTGGLM
210 220 230 240 250
GGDLTSGAGT SAGNGYGNPR NSPGLLVSPG NLNKNMQAKS PPPMNLGMNN
260 270 280 290 300
RKPDLRVLIP PGSKNTMPSV SEDVDLLLNQ RINNSQSAQS LATPVVSVAT
310 320 330 340 350
PTLPGQGMGG YPSAISTTYG TEYSLSSADL SSLSGFNTAS ALHLGSVTGW
360 370 380 390 400
QQQHLHNMPP SALSQLGACT STHLSQSSNL SLPSTQSLNI KSEPVSPPRD
410 420 430 440 450
RTTTPSRYPQ HTRHEAGRSP VDSLSSCSSS YDGSDREDHR NEFHSPIGLT
460 470
RPSPDERESP SVKRMRLSEG WAT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471084 Genomic DNA Translation: EAW95962.1 CH471084 Genomic DNA Translation: EAW95968.1 |
RefSeqi | NP_001180279.1, NM_001193350.1 NP_002388.2, NM_002397.4 XP_005248568.1, XM_005248511.2 XP_006714682.1, XM_006714619.2 XP_011541698.1, XM_011543396.2 |
Genome annotation databases
GeneIDi | 4208 |
KEGGi | hsa:4208 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471084 Genomic DNA Translation: EAW95962.1 CH471084 Genomic DNA Translation: EAW95968.1 |
RefSeqi | NP_001180279.1, NM_001193350.1 NP_002388.2, NM_002397.4 XP_005248568.1, XM_005248511.2 XP_006714682.1, XM_006714619.2 XP_011541698.1, XM_011543396.2 |
3D structure databases
SMRi | A0A024RAL7 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 755, 1262 antibodies |
Genome annotation databases
GeneIDi | 4208 |
KEGGi | hsa:4208 |
Organism-specific databases
CTDi | 4208 |
EuPathDBi | HostDB:ENSG00000081189.13 |
Miscellaneous databases
BioGRID-ORCSi | 4208, 27 hits in 867 CRISPR screens |
ChiTaRSi | MEF2C, human |
GenomeRNAii | 4208 |
Gene expression databases
Bgeei | ENSG00000081189, Expressed in middle temporal gyrus and 241 other tissues |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR022102, HJURP_C IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF12347, HJURP_C, 1 hit PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RAL7_HUMAN | |
Accessioni | A0A024RAL7Primary (citable) accession number: A0A024RAL7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |