UniProtKB - A0A024RAK9 (A0A024RAK9_HUMAN)
Protein
Submitted name:
Hyaluronan and proteoglycan link protein 1, isoform CRA_a
Gene
HAPLN1
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- hyaluronic acid binding Source: InterPro
GO - Biological processi
- cell adhesion Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Hyaluronan and proteoglycan link protein 1, isoform CRA_aImported |
Gene namesi | Name:HAPLN1Imported ORF Names:hCG_39210Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000145681.10 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix Source: Ensembl
Other locations
- synapse Source: Ensembl
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_5012429665 | 16 – 354 | Sequence analysisAdd BLAST | 339 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 205 ↔ 226 | PROSITE-ProRule annotation | ||
Disulfide bondi | 304 ↔ 325 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000145681, Expressed in tibia and 148 other tissues |
ExpressionAtlasi | A0A024RAK9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 152 | Ig-likeInterPro annotationAdd BLAST | 115 | |
Domaini | 159 – 254 | LinkInterPro annotationAdd BLAST | 96 | |
Domaini | 259 – 351 | LinkInterPro annotationAdd BLAST | 93 |
Keywords - Domaini
Immunoglobulin domainARBA annotation, SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_052285_1_0_1 |
OMAi | ISVCWAD |
OrthoDBi | 743812at2759 |
PhylomeDBi | A0A024RAK9 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 2 hits |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom |
Pfami | View protein in Pfam PF07686, V-set, 1 hit PF00193, Xlink, 2 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00445, LINK, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS01241, LINK_1, 2 hits PS50963, LINK_2, 2 hits |
i Sequence
Sequence statusi: Complete.
A0A024RAK9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSLLLLVLI SICWADHLSD NYTLDHDRAI HIQAENGPHL LVEAEQAKVF
60 70 80 90 100
SHRGGNVTLP CKFYRDPTAF GSGIHKIRIK WTKLTSDYLK EVDVFVSMGY
110 120 130 140 150
HKKTYGGYQG RVFLKGGSDS DASLVITDLT LEDYGRYKCE VIEGLEDDTV
160 170 180 190 200
VVALDLQGVV FPYFPRLGRY NLNFHEAQQA CLDQDAVIAS FDQLYDAWRG
210 220 230 240 250
GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF WDKDKSRYDV
260 270 280 290 300
FCFTSNFNGR FYYLIHPTKL TYDEAVQACL NDGAQIAKVG QIFAAWKILG
310 320 330 340 350
YDRCDAGWLA DGSVRYPISR PRRRCSPTEA AVRFVGFPDK KHKLYGVYCF
RAYN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471084 Genomic DNA Translation: EAW95913.1 |
RefSeqi | NP_001875.1, NM_001884.3 XP_011541470.1, XM_011543168.2 XP_016864540.1, XM_017009051.1 XP_016864541.1, XM_017009052.1 |
Genome annotation databases
GeneIDi | 1404 |
KEGGi | hsa:1404 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471084 Genomic DNA Translation: EAW95913.1 |
RefSeqi | NP_001875.1, NM_001884.3 XP_011541470.1, XM_011543168.2 XP_016864540.1, XM_017009051.1 XP_016864541.1, XM_017009052.1 |
3D structure databases
SMRi | A0A024RAK9 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 12888, 226 antibodies |
Genome annotation databases
GeneIDi | 1404 |
KEGGi | hsa:1404 |
Organism-specific databases
CTDi | 1404 |
VEuPathDBi | HostDB:ENSG00000145681.10 |
Phylogenomic databases
HOGENOMi | CLU_052285_1_0_1 |
OMAi | ISVCWAD |
OrthoDBi | 743812at2759 |
PhylomeDBi | A0A024RAK9 |
Miscellaneous databases
BioGRID-ORCSi | 1404, 4 hits in 874 CRISPR screens |
ChiTaRSi | HAPLN1, human |
GenomeRNAii | 1404 |
Gene expression databases
Bgeei | ENSG00000145681, Expressed in tibia and 148 other tissues |
ExpressionAtlasi | A0A024RAK9, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 2 hits |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom |
Pfami | View protein in Pfam PF07686, V-set, 1 hit PF00193, Xlink, 2 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00445, LINK, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS01241, LINK_1, 2 hits PS50963, LINK_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RAK9_HUMAN | |
Accessioni | A0A024RAK9Primary (citable) accession number: A0A024RAK9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 10, 2021 | |
This is version 43 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |