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Entry version 20 (16 Oct 2019)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Zinc finger, UBR1 type 1, isoform CRA_c

Gene

ZUBR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger, UBR1 type 1, isoform CRA_cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZUBR1Imported
ORF Names:hCG_1984462Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A024RAC9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni129 – 182DisorderedSequence analysisAdd BLAST54
Regioni251 – 385DisorderedSequence analysisAdd BLAST135
Regioni760 – 803DisorderedSequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi251 – 309PolarSequence analysisAdd BLAST59
Compositional biasi347 – 367PolarSequence analysisAdd BLAST21
Compositional biasi368 – 385PolyampholyteSequence analysisAdd BLAST18
Compositional biasi760 – 783PolarSequence analysisAdd BLAST24
Compositional biasi784 – 803PolyampholyteSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1776 Eukaryota
ENOG410XPP8 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR025704 E3_Ub_ligase_UBR4

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13764 E3_UbLigase_R4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024RAC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPNNLVHFT ESKLPQMETE GMDEGKEPQK QLEGDCCSFI TQLVNHFWKL
60 70 80 90 100
HASKPKNAFL APACLPGLTH IEATVNALVD IIHGYCTCEL DCINTASKIY
110 120 130 140 150
MQMLLCPDPA VSFSCKQALI RVLRPRNKRR HVTLPSSPRS NTPMGDKDDD
160 170 180 190 200
DDDDADEKMQ SSGIPNGGHI RQESQEQSEV DHGDFEMVSE SMVLETAENV
210 220 230 240 250
NNGNPSPLEA LLAGAEGFPP MLDIPPDADD ETMVELAIAL SLQQDQQGSS
260 270 280 290 300
SSALGLQSLG LSGQAPSSSS LDAGTLSDTT ASAPASDDEG STAATDGSTL
310 320 330 340 350
RTSPADHGGS VGSESGGSAV DSVAGEHSVS GRSSAYGDAT AEGHPAGPGS
360 370 380 390 400
VSSSTGAIST TTGHQEGDGS EGEGEGETEG DVHTSNRLHM VRLMLLERLL
410 420 430 440 450
QTLPQLRNVG GVRAIPYMQV ILMLTTDLDG EDEKDKGALD NLLSQLIAEL
460 470 480 490 500
GMDKKDVSKK NERSALNEVH LVVMRLLSVF MSRTKSGSKS SICESSSLIS
510 520 530 540 550
SATAAALLSS GAVDYCLHVL KSLLEYWKSQ QNDEEPVATS QLLKPHTTSS
560 570 580 590 600
PPDMSPFFLR QYVKGHAADV FEAYTQLLTE MVLRLPYQIK KITDTNSRIP
610 620 630 640 650
PPVFDHSWFY FLSEYLMIQQ TPFVRRQVRK LLLFICGSKE KYRQLRDLHT
660 670 680 690 700
LDSHVRGIKK LLEEQGIFLR ASVVTASSGS ALQYDTLISL MEHLKACAEI
710 720 730 740 750
AAQRTINWQK FCIKDDSVLY FLLQVSFLVD EGVSPVLLQL LSCALCGSKV
760 770 780 790 800
LAALAASSGS SSASSSSAPV AASSGQATTQ SKSSTKKSKK EEKEKEKDGE
810 820 830 840 850
TSGSQEDQLC TALVNQLNKF ADKETLIQFL RCFLLESNSS SVRWQAHCLT
860 870 880 890 900
LHIYRNSSKS QQELLLDLMW SIWPELPAYG RKAAQFVDLL GYFSLKTPQT
910 920 930 940 950
EKKLKEYSQK AVEILRTQNH ILTNHPNSNI YNTLSGLVEF DGYYLESDPC
960 970 980 990 1000
LVCNNPEVPF CYIKLSSIKV DTRYTTTQQV VKLIGSHTIS KVTVKIGDLK
1010 1020 1030 1040 1050
RTKMVRTINL YYNNRTVQAI VELKNKPARW HKAKKVQLTP GQTEVKIDLP
1060 1070 1080 1090 1100
LPIVASNLMI EFADFYENYQ ASTETLQCPR CSASVPANPG VCGNCGENVY
1110 1120 1130 1140 1150
QCHKCRSINY DEKDPFLCNA CGFCKYARFD FMLYAKPCCA VDPIENEEDR
1160 1170 1180 1190 1200
KKAVSNINTL LDKADRVYHQ LMGHRPQLEN LLCKVNEAAP EKPQDDSGTA
1210 1220 1230 1240 1250
GGISSTSASV NRYILQLAQE YCGDCKNSFD ELSKIIQKVF ASRKELLEYD
1260 1270 1280 1290 1300
LQQREAATKS SRTSVQPTFT ASQYRALSVL GCGHTSSTKC YGCASAVTEH
1310 1320 1330 1340 1350
CITLLRALAT NPALRHILVS QGLIRELFDY NLRRGAAAMR EEVRQLMCLL
1360 1370 1380 1390 1400
TRDNPEATQQ MNDLIIGKVS TALKGHWANP DLASSLQYEM LLLTDSISKE
1410 1420 1430 1440 1450
DSCWELRLRC ALSLFLMAVN IKTPVVVENI TLMCLRILQK LIKPPAPTSK
1460 1470 1480 1490 1500
KNKDVPVEAL TTVKPYCNEI HAQAQLWLKR DPKASYDAWK KCLPIRGIDG
1510 1520 1530 1540 1550
NGKAPSKSEL RHLYLTEKYV WRWKQFLSRR GKRTSPLDLK LGHNNWLRQV
1560 1570 1580 1590 1600
LFTPATQAAR QAACTIVEAL ATIPSRKQQV LDLLTSYLDE LSIAGECAAE
1610 1620 1630 1640 1650
YLALYQKLIT SAHWKVYLAA RGVLPYVGNL ITKEIARLLA LEEATLSTDL
1660 1670 1680 1690 1700
QQGYALKSLT GLLSSFVEVE SIKRHFKSRL VGTVLNGYLC LRKLVVQRTK
1710 1720 1730 1740 1750
LIDETQDMLL EMLEDMTTGT ESETKAFMAV CIETAKRYNL DDYRTPVFIF
1760 1770 1780 1790 1800
ERLCSIIYPE ENEVTEFFVT LEKDPQQEDF LQGRMPGNPY SSNEPGIGPL
1810 1820 1830 1840 1850
MRDIKNKICQ DCDLVALLED DSGMELLVNN KIISLDLPVA EVYKKVWCTT
1860 1870 1880 1890 1900
NEGEPMRIVY RMRGLLGDAT EEFIESLDST TDEEEDEEEV YKMAGVMAQC
1910 1920 1930 1940 1950
GGLECMLNRL AGIRDFKQGR HLLTVLLKLF SYCVKVKVNR QQLVKLEMNT
1960 1970 1980 1990 2000
LNVMLGTLNL ALVAEQESKD SGGAAVAEQV LSIMEIILDE SNAEPLSEDK
2010 2020 2030 2040 2050
GNLLLTGDKD QLVMLLDQIN STFVRSNPSV LQGLLRIIPY LSFGEVEKMQ
2060 2070 2080 2090 2100
ILVERFKPYC NFDKYDEDHS GDDKVFLDCF CKIAAGIKNN SNGHQLKDLI
2110 2120 2130 2140 2150
LQKGITQNAL DYMKKHIPSA KNLDADIWKK FLSRPALPFI LRLLRGLAIQ
2160 2170 2180 2190 2200
HPGTQVLIGT DSIPNLHKLE QVSSDEGIGT LAENLLEALR EHPDVNKKID
2210 2220 2230 2240 2250
AARRETRAEK KRMAMAMRQK ALGTLGMTTN EKGQVVTKTA LLKQMEELIE
2260 2270 2280 2290 2300
EPGLTCCICR EGYKFQPTKV LGIYTFTKRV ALEELENKPR KQQGYSTVSH
2310 2320 2330 2340 2350
FNIVHYDCHL AAVRLARGRE EWESAALQNA NTKCNGLLPV WGPHVPESAF
2360 2370 2380 2390 2400
ATCLARHNTY LQECTGQREP TYQLNIHDIK LLFLRFAMEQ SFSADTGGGG
2410 2420 2430 2440 2450
RESNIHLIPY IIHTVLYVLN TTRATSREEK NLQGFLEQPK EKWVESAFEV
2460 2470 2480 2490 2500
DGPYYFTVLA LHILPPEQWR ATRVEILRRL LVTSQARAVA PGGATRLTDK
2510 2520 2530 2540 2550
AVKDYSAYRS SLLFWALVDL IYNMFKKVPT SNTEGGWSCS LAEYIRHNDM
2560 2570 2580 2590 2600
PIYEAADKAL KTFQEEFMPV ETFSEFLDVA GLLSEITDPE SFLKDLLNSV

P
Length:2,601
Mass (Da):289,699
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F8BF0C574FF4C8F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471134 Genomic DNA Translation: EAW94866.1
CH471134 Genomic DNA Translation: EAW94869.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471134 Genomic DNA Translation: EAW94866.1
CH471134 Genomic DNA Translation: EAW94869.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA0A024RAC9

Phylogenomic databases

eggNOGiKOG1776 Eukaryota
ENOG410XPP8 LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UBR4 human

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR025704 E3_Ub_ligase_UBR4
PfamiView protein in Pfam
PF13764 E3_UbLigase_R4, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024RAC9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024RAC9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 16, 2019
This is version 20 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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