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Entry version 38 (12 Aug 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Sorting nexin 13, isoform CRA_b

Gene

SNX13

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transportARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sorting nexin 13, isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNX13Imported
ORF Names:hCG_2009798Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000071189.21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 24HelicalSequence analysisAdd BLAST18
Transmembranei30 – 51HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A0A024R9Z9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000071189, Expressed in stomach and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A024R9Z9, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A024R9Z9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini97 – 284PXAInterPro annotationAdd BLAST188
Domaini373 – 496RGSInterPro annotationAdd BLAST124
Domaini559 – 680PXInterPro annotationAdd BLAST122

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili293 – 313Sequence analysisAdd BLAST21
Coiled coili783 – 803Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sorting nexin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005899_1_0_1

KEGG Orthology (KO)

More...
KOi
K17925

Identification of Orthologs from Complete Genome Data

More...
OMAi
CETINNT

Database of Orthologous Groups

More...
OrthoDBi
187001at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06873, PX_SNX13, 1 hit
cd08719, RGS_SNX13, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001683, Phox
IPR003114, Phox_assoc
IPR036871, PX_dom_sf
IPR016137, RGS
IPR036305, RGS_sf
IPR037437, SNX13_PX
IPR037896, SNX13_RGS
IPR013937, Sorting_nexin_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08628, Nexin_C, 1 hit
PF00787, PX, 1 hit
PF02194, PXA, 1 hit
PF00615, RGS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00312, PX, 1 hit
SM00313, PXA, 1 hit
SM00315, RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097, SSF48097, 1 hit
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195, PX, 1 hit
PS51207, PXA, 1 hit
PS50132, RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R9Z9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTEASLSIW GWGSLGIVLF LITFGPFVIF YLTFYILCFV GGGLVVTLLF
60 70 80 90 100
GKTNSEKYLE QCEHSFLPPT SPGVPKCLEE MKREARTIKI DRRLTGANII
110 120 130 140 150
DEPLQQVIQF SLRDYVQYWY YTLSDDESFL LEIRQTLQNA LIQFATRSKE
160 170 180 190 200
IDWQPYFTTR IVDDFGTHLR VFRKAQQKIT EKDDQVKGTA EDLVDTFFEV
210 220 230 240 250
EVEMEKEVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD FQNKIMRYFV
260 270 280 290 300
REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI
310 320 330 340 350
GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR
360 370 380 390 400
LQSGKEINTV KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL
410 420 430 440 450
FFWMTVEGYR VTAQQQLEVL LSRQRDGKHQ TNQTKGLLRA AAVGIYEQYL
460 470 480 490 500
SEKASPRVTV DDYLVAKLAD TLNHEDPTPE IFDDIQRKVY ELMLRDERFY
510 520 530 540 550
PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT GSINLSLDDL
560 570 580 590 600
SNVSSDDSVQ LHAYISDTGV CNDHGKTYAL YAITVHRRNL NSEEMWKTYR
610 620 630 640 650
RYSDFHDFHM RITEQFESLS SILKLPGKKT FNNMDRDFLE KRKKDLNAYL
660 670 680 690 700
QLLLAPEMMK ASPALAHYVY DFLENKAYSK GKGDFARKMD TFVNPLRNSM
710 720 730 740 750
RNVSNAVKSL PDSLAEGMTK MSDNMGKMSE RLGQDIKQSF FKVPPLIPKT
760 770 780 790 800
DSDPEHRRVS AQLDDNVDDN IPLRVMLLLM DEVFDLKERN QWLRRNIKNL
810 820 830 840 850
LQQLIRATYG DTINRKIVDH VDWMTSPEQV ADSVKRFRDA FWPNGILAEA
860 870 880 890 900
VPCRDKSIRM RTRVAGKTKL LAIMPDELKH IIGAETTRKG ILRVFEMFQH
910 920 930 940 950
NQLNRRMVYV FLEGFLETLF PQYKFRELFN KLHSRSKQMQ KYKQKLQTTQ

APSLQKR
Length:957
Mass (Da):110,960
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC41207BE22F3557
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471073 Genomic DNA Translation: EAW93693.1

NCBI Reference Sequences

More...
RefSeqi
NP_055947.1, NM_015132.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23161

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23161

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471073 Genomic DNA Translation: EAW93693.1
RefSeqiNP_055947.1, NM_015132.4

3D structure databases

SMRiA0A024R9Z9
ModBaseiSearch...

Proteomic databases

PRIDEiA0A024R9Z9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25298, 86 antibodies

Genome annotation databases

GeneIDi23161
KEGGihsa:23161

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23161
EuPathDBiHostDB:ENSG00000071189.21

Phylogenomic databases

HOGENOMiCLU_005899_1_0_1
KOiK17925
OMAiCETINNT
OrthoDBi187001at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23161, 28 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SNX13, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23161

Gene expression databases

BgeeiENSG00000071189, Expressed in stomach and 241 other tissues
ExpressionAtlasiA0A024R9Z9, baseline and differential

Family and domain databases

CDDicd06873, PX_SNX13, 1 hit
cd08719, RGS_SNX13, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683, Phox
IPR003114, Phox_assoc
IPR036871, PX_dom_sf
IPR016137, RGS
IPR036305, RGS_sf
IPR037437, SNX13_PX
IPR037896, SNX13_RGS
IPR013937, Sorting_nexin_C
PfamiView protein in Pfam
PF08628, Nexin_C, 1 hit
PF00787, PX, 1 hit
PF02194, PXA, 1 hit
PF00615, RGS, 1 hit
SMARTiView protein in SMART
SM00312, PX, 1 hit
SM00313, PXA, 1 hit
SM00315, RGS, 1 hit
SUPFAMiSSF48097, SSF48097, 1 hit
SSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195, PX, 1 hit
PS51207, PXA, 1 hit
PS50132, RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R9Z9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R9Z9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: August 12, 2020
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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