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Entry version 57 (19 Jan 2022)
Sequence version 1 (09 Jul 2014)
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Protein

HECT-type E3 ubiquitin transferase

Gene

HUWE1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4332Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseARBA annotation
Biological processDNA damage, DNA repairARBA annotation, Ubl conjugation pathwayPROSITE-ProRule annotationARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HECT-type E3 ubiquitin transferaseARBA annotation (EC:2.3.2.26ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HUWE1Imported
ORF Names:hCG_2000770Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000086758

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000086758, Expressed in lung and 249 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1307 – 1346UBAInterPro annotationAdd BLAST40
Domaini1594 – 1671WWEInterPro annotationAdd BLAST78
Domaini4029 – 4365HECTInterPro annotationAdd BLAST337

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni706 – 759DisorderedSequence analysisAdd BLAST54
Regioni1006 – 1028DisorderedSequence analysisAdd BLAST23
Regioni1282 – 1311DisorderedSequence analysisAdd BLAST30
Regioni1387 – 1406DisorderedSequence analysisAdd BLAST20
Regioni1680 – 1726DisorderedSequence analysisAdd BLAST47
Regioni2009 – 2056DisorderedSequence analysisAdd BLAST48
Regioni2253 – 2333DisorderedSequence analysisAdd BLAST81
Regioni2347 – 2471DisorderedSequence analysisAdd BLAST125
Regioni2685 – 2961DisorderedSequence analysisAdd BLAST277
Regioni3027 – 3050DisorderedSequence analysisAdd BLAST24
Regioni3236 – 3258DisorderedSequence analysisAdd BLAST23
Regioni3395 – 3415DisorderedSequence analysisAdd BLAST21
Regioni3462 – 3503DisorderedSequence analysisAdd BLAST42
Regioni3528 – 3559DisorderedSequence analysisAdd BLAST32
Regioni3728 – 3749DisorderedSequence analysisAdd BLAST22
Regioni3772 – 3839DisorderedSequence analysisAdd BLAST68
Regioni3885 – 3922DisorderedSequence analysisAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3081 – 3101Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi737 – 756Polar residuesSequence analysisAdd BLAST20
Compositional biasi1282 – 1301Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1690 – 1712Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi2009 – 2026Polar residuesSequence analysisAdd BLAST18
Compositional biasi2027 – 2051Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi2253 – 2286Polar residuesSequence analysisAdd BLAST34
Compositional biasi2375 – 2393Polar residuesSequence analysisAdd BLAST19
Compositional biasi2397 – 2462Acidic residuesSequence analysisAdd BLAST66
Compositional biasi2685 – 2709Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi2710 – 2767Polar residuesSequence analysisAdd BLAST58
Compositional biasi2806 – 2878Polar residuesSequence analysisAdd BLAST73
Compositional biasi2896 – 2925Polar residuesSequence analysisAdd BLAST30
Compositional biasi3032 – 3050Polar residuesSequence analysisAdd BLAST19
Compositional biasi3236 – 3251Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi3462 – 3493Polar residuesSequence analysisAdd BLAST32
Compositional biasi3774 – 3790Polar residuesSequence analysisAdd BLAST17
Compositional biasi3804 – 3821Polar residuesSequence analysisAdd BLAST18
Compositional biasi3885 – 3902Basic and acidic residuesSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000058_0_0_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078, HECTc, 1 hit
cd14288, UBA_HUWE1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.720.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR010309, E3_Ub_ligase_DUF908
IPR010314, E3_Ub_ligase_DUF913
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR025527, HUWE1/Rev1_UBM
IPR015940, UBA
IPR009060, UBA-like_sf
IPR041918, UBA_HUWE1
IPR004170, WWE-dom
IPR037197, WWE_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06012, DUF908, 1 hit
PF06025, DUF913, 1 hit
PF00632, HECT, 1 hit
PF00627, UBA, 1 hit
PF14377, UBM, 3 hits
PF02825, WWE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119, HECTc, 1 hit
SM00165, UBA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117839, SSF117839, 1 hit
SSF46934, SSF46934, 1 hit
SSF48371, SSF48371, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237, HECT, 1 hit
PS50030, UBA, 1 hit
PS50918, WWE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R9U8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE
60 70 80 90 100
LYHWVDLLDR FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT
110 120 130 140 150
ALLIEYSFSR HLYSSIEHLT TLLASSDMQV VLAVLNLLYV FSKRSNYITR
160 170 180 190 200
LGSDKRTPLL TRLQHLAESW GGKENGFGLA ECCRDLHMMK YPPSATTLHF
210 220 230 240 250
EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM ESLTKMYSIP
260 270 280 290 300
KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI
310 320 330 340 350
LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT
360 370 380 390 400
GTASYHGFLP VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG
410 420 430 440 450
EALVSCGMME ALLKVIKFLG DEQDQITFVT RAVRVVDLIT NLDMAAFQSH
460 470 480 490 500
SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ RPNTTQEGEE METDMDGVQC
510 520 530 540 550
IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL KHIISNAEYY
560 570 580 590 600
GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV
610 620 630 640 650
LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD
660 670 680 690 700
PLGDTASNLG SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ
710 720 730 740 750
KPSIQKADGT ATAPPPRSNH AAEEASSEDE EEEEVQAMQS FNSTQQNETE
760 770 780 790 800
PNQQVVGTEE RIPIPLMDYI LNVMKFVESI LSNNTTDDHC QEFVNQKGLL
810 820 830 840 850
PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV LQEGLLQLDS
860 870 880 890 900
ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH
910 920 930 940 950
AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV
960 970 980 990 1000
LLSLCTPNSL PSGCEFGQAD MQKLVPKDEK ADGEQDGAAG SMDASTQGLL
1010 1020 1030 1040 1050
EGIGLDGDTL APMETDEPTA SDSKGKSKIT PAMAARIKQI KPLLSASSRL
1060 1070 1080 1090 1100
GRALAELFGL LVKLCVGSPV RQRRSHHAAS TTTAPTPAAR STASALTKLL
1110 1120 1130 1140 1150
TKGLSWQPPP YTPTPRFRLT FFICSVGFTS PMLFDERKYP YHLMLQKFLC
1160 1170 1180 1190 1200
SGGHNALFET FNWALSMGGK VPVSEGLEHS DLPDGTGEFL DAWLMLVEKM
1210 1220 1230 1240 1250
VNPTTVLESP HSLPAKLPGG VQNFPQFSAL RFLVVTQKAA FTCIKNLWNR
1260 1270 1280 1290 1300
KPLKVYGGRM AESMLAILCH ILRGEPVIRE RLSKEKEGSR GEEDTGQEEG
1310 1320 1330 1340 1350
GSRREPQVNQ QQLQQLMDMG FTREHAMEAL LNTSTMEQAT EYLLTHPPPI
1360 1370 1380 1390 1400
MGGVVRDLSM SEEDQMMRAI AMSLGQDIPM DQRAESPEEV ACRKEEEERK
1410 1420 1430 1440 1450
AREKQEEEEA KCLEKFQDAD PLEQDELHTF TDTMLPGCFH LLDELPDTVY
1460 1470 1480 1490 1500
RVCDLIMTAI KRNGADYRDM ILKQVVNQVW EAADVLIKAA LPLTTSDTKT
1510 1520 1530 1540 1550
VSEWISQMAT LPQASNLATR ILLLTLLFEE LKLPCAWVVE SSGILNVLIK
1560 1570 1580 1590 1600
LLEVVQPCLQ AAKEQKEVQT PKWITPVLLL IDFYEKTAIS SKRRAQMTKY
1610 1620 1630 1640 1650
LQSNSNNWRW FDDRSGRWCS YSASNNSTID SAWKSGETSV RFTAGRRRYT
1660 1670 1680 1690 1700
VQFTTMVQVN EETGNRRPVM LTLLRVPRLN KNSKNSNGQE LEKTLEESKE
1710 1720 1730 1740 1750
MDIKRKENKG NDTPLALEST NTEKETSLEE TKIGEILIQG LTEDMVTVLI
1760 1770 1780 1790 1800
RACVSMLGVP VDPDTLHATL RLCLRLTRDH KYAMMFAELK STRMILNLTQ
1810 1820 1830 1840 1850
SSGFNGFTPL VTLLLRHIIE DPCTLRHTME KVVRSAATSG AGSTTSGVVS
1860 1870 1880 1890 1900
GSLGSREINY ILRVLGPAAC RNPDIFTEVA NCCIRIALPA PRGSGTASDD
1910 1920 1930 1940 1950
EFENLRIKGP NAVQLVKTTP LKPSPLPVIP DTIKEVIYDM LNALAAYHAP
1960 1970 1980 1990 2000
EEADKSDPKP GVMTQEVGQL LQDMGDDVYQ QYRSLTRQSS DFDTQSGFSI
2010 2020 2030 2040 2050
NSQVFAADGA STETSASGTS QGEASTPEES RDGKKDKEGD RASEEGKQKG
2060 2070 2080 2090 2100
KGSKPLMPTS TILRLLAELV RSYVGIATLI ANYSYTVGQS ELIKEDCSVL
2110 2120 2130 2140 2150
AFVLDHLLPH TQNAEDKDTP ALARLFLASL AAAGSGTDAQ VALVNEVKAA
2160 2170 2180 2190 2200
LGRALAMAES TEKHARLQAV MCIISTIMES CPSTSSFYSS ATAKTQHNGM
2210 2220 2230 2240 2250
NNIIRLFLKK GLVNDLARVP HSLDLSSPNM ANTVNAALKP LETLSRIVNQ
2260 2270 2280 2290 2300
PSSLFGSKSA SSKNKSEQDA QGASQDSSSN QQDPGEPGEA EVQEEDHDVT
2310 2320 2330 2340 2350
QTEVADGDIM DGEAETDSVV IAGQPEVLSS QEMQVENELE DLIDELLERD
2360 2370 2380 2390 2400
GGSGNSTIIV SRSGEDESQE DVLMDEAPSN LSQASTLQAN REDSMNILDP
2410 2420 2430 2440 2450
EDEEEHTQEE DSSGSNEDED DSQDEEEEEE EDEEDDQEDD EGEEGDEDDD
2460 2470 2480 2490 2500
DDGSEMELDE DYPDMNASPL VRFERFDRED DLIIEFDNMF SSATDIPPSP
2510 2520 2530 2540 2550
GNIPTTHPLM VRHADHSSLT LGSGSSTTRL TQGIGRSQRT LRQLTANTGH
2560 2570 2580 2590 2600
TIHVHYPGNR QPNPPLILQR LLGPSAAADI LQLSSSLPLQ SRGRARLLVG
2610 2620 2630 2640 2650
NDDVHIIARS DDELLDDFFH DQSTATSQAG TLSSIPTALT RWTEECKVLD
2660 2670 2680 2690 2700
AESMHDCVSV VKVSIVNHLE FLRDEELEER REKRRKQLAE EETKITDKGK
2710 2720 2730 2740 2750
EDKENRDQSA QCTASKSNDS TEQNLSDGTP MPDSYPTTPS STDAATSESK
2760 2770 2780 2790 2800
ETLGTLQSSQ QQPTLPTPPA LGEVPQELQS PAGEGGSSTQ LLMPVEPEEL
2810 2820 2830 2840 2850
GPTRPSGEAE TTQMELSPAP TITSLSPERA EDSDALTAVS SQLEGSPMDT
2860 2870 2880 2890 2900
SSLASCTLEE AVGDTSAAGS SEQPRAGSST PGDAPPAVAE VQGRSDGSGE
2910 2920 2930 2940 2950
SAQPPEDSSP PASSESSSTR DSAVAISGAD SRGILEEPLP STSSEEEDPL
2960 2970 2980 2990 3000
AGISLPEGVD PSFLAALPDD IRREVLQNQL GIRPPTRTAP STNSSAPAVV
3010 3020 3030 3040 3050
GNPGVTEVSP EFLAALPPAI QEEVLAQQRA EQQRRELAQN ASSDTPMDPV
3060 3070 3080 3090 3100
TFIQTLPSDL RRSVLEDMED SVLAVMPPDI AAEAQALRRE QEARQRQLMH
3110 3120 3130 3140 3150
ERLFGHSSTS ALSAILRSPA FTSRLSGNRG VQYTRLAVQR GGTFQMGGSS
3160 3170 3180 3190 3200
SHNRPSGSNV DTLLRLRGRL LLDHEALSCL LVLLFVDEPK LNTSRLHRVL
3210 3220 3230 3240 3250
RNLCYHAQTR HWVIRSLLSI LQRSSESELC IETPKLTTSE EKGKKSSKSC
3260 3270 3280 3290 3300
GSSSHENRPL DLLHKMESKS SNQLSWLSVS MDAALGCRTN IFQIQRSGGR
3310 3320 3330 3340 3350
KHTEKHASGG STVHIHPQAA PVVCRHVLDT LIQLAKVFPS HFTQQRTKET
3360 3370 3380 3390 3400
NCESDRERGN KACSPCSSQS SSSGICTDFW DLLVKLDNMN VSRKGKNSVK
3410 3420 3430 3440 3450
SVPVSAGGEG ETSPYSLEAS PLGQLMNMLS HPVIRRSSLL TEKLLRLLSL
3460 3470 3480 3490 3500
ISIALPENKV SEAQANSGSG ASSTTTATST TSTTTTTAAS TTPTPPTAPT
3510 3520 3530 3540 3550
PVTSAPALVA ATAISTIVVA ASTTVTTPTT ATTTVSISPT TKGSKSPAKV
3560 3570 3580 3590 3600
SDGGSSSTDF KMVSSGLTEN QLQLSVEVLT SHSCSEEGLE DAANVLLQLS
3610 3620 3630 3640 3650
RGDSGTRDTV LKLLLNGARH LGYTLCKQIG TLLAELREYN LEQQRRAQCE
3660 3670 3680 3690 3700
TLSPDGLPEE QPQTTKLKGK MQSRFDMAEN VVIVASQKRP LGGRELQLPS
3710 3720 3730 3740 3750
MSMLTSKTST QKFFLRVLQV IIQLRDDTRR ANKKAKQTGR LGSSGLGSAS
3760 3770 3780 3790 3800
SIQAAVRQLE AEADAIIQMV REGQRARRQQ QAATSESSQS EASVRREESP
3810 3820 3830 3840 3850
MDVDQPSPSA QDTQSIASDG TPQGEKEKEE RPPELPLLSE QLSLDELWDM
3860 3870 3880 3890 3900
LGECLKELEE SHDQHAVLVL QPAVEAFFLV HATERESKPP VRDTRESQLA
3910 3920 3930 3940 3950
HIKDEPPPLS PAPLTPATPS SLDPFFSREP SSMHISSSLP PDTQKFLRFA
3960 3970 3980 3990 4000
ETHRTVLNQI LRQSTTHLAD GPFAVLVDYI RVLDFDVKRK YFRQELERLD
4010 4020 4030 4040 4050
EGLRKEDMAV HVRRDHVFED SYRELHRKSP EEMKNRLYIV FEGEEGQDAG
4060 4070 4080 4090 4100
GLLREWYMII SREMFNPMYA LFRTSPGDRV TYTINPSSHC NPNHLSYFKF
4110 4120 4130 4140 4150
VGRIVAKAVY DNRLLECYFT RSFYKHILGK SVRYTDMESE DYHFYQGLVY
4160 4170 4180 4190 4200
LLENDVSTLG YDLTFSTEVQ EFGVCEVRDL KPNGANILVT EENKKEYVHL
4210 4220 4230 4240 4250
VCQMRMTGAI RKQLAAFLEG FYEIIPKRLI SIFTEQELEL LISGLPTIDI
4260 4270 4280 4290 4300
DDLKSNTEYH KYQSNSIQIQ WFWRALRSFD QADRAKFLQF VTGTSKVPLQ
4310 4320 4330 4340 4350
GFAALEGMNG IQKFQIHRDD RSTDRLPSAH TCFNQLDLPA YESFEKLRHM
4360
LLLAIQECSE GFGLA
Length:4,365
Mass (Da):481,018
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8A8FFC3C7EB9B24
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CH471154 Genomic DNA Translation: EAW93162.1
CH471154 Genomic DNA Translation: EAW93163.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471154 Genomic DNA Translation: EAW93162.1
CH471154 Genomic DNA Translation: EAW93163.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
448, 166 antibodies from 35 providers

Organism-specific databases

VEuPathDBiHostDB:ENSG00000086758

Phylogenomic databases

HOGENOMiCLU_000058_0_0_1

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HUWE1, human

Gene expression databases

BgeeiENSG00000086758, Expressed in lung and 249 other tissues

Family and domain databases

CDDicd00078, HECTc, 1 hit
cd14288, UBA_HUWE1, 1 hit
Gene3Di3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR010309, E3_Ub_ligase_DUF908
IPR010314, E3_Ub_ligase_DUF913
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR025527, HUWE1/Rev1_UBM
IPR015940, UBA
IPR009060, UBA-like_sf
IPR041918, UBA_HUWE1
IPR004170, WWE-dom
IPR037197, WWE_dom_sf
PfamiView protein in Pfam
PF06012, DUF908, 1 hit
PF06025, DUF913, 1 hit
PF00632, HECT, 1 hit
PF00627, UBA, 1 hit
PF14377, UBM, 3 hits
PF02825, WWE, 1 hit
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SM00165, UBA, 1 hit
SUPFAMiSSF117839, SSF117839, 1 hit
SSF46934, SSF46934, 1 hit
SSF48371, SSF48371, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit
PS50030, UBA, 1 hit
PS50918, WWE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R9U8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R9U8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: January 19, 2022
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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