VPS18

Functionⁱ

GO - Molecular functionⁱ

actin binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

endosome organization Source: Ensembl
intracellular protein transport Source: UniProtKB-UniRule
vesicle-mediated transport Source: InterPro
viral entry into host cell Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Vacuolar protein sorting protein 18, isoform CRA_dImported
Gene namesⁱ	Name:VPS18Imported ORF Names:hCG_38959Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104142.10

EuPathDBⁱ

HostDB:ENSG00000104142.10

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000104142 Expressed in 181 organ(s), highest expression level in tendon of biceps brachii

Bgeeⁱ

ENSG00000104142 Expressed in 181 organ(s), highest expression level in tendon of biceps brachii

Interactionⁱ

GO - Molecular functionⁱ

actin binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	291 – 434	Pep3_Vps18InterPro annotationAdd BLAST		144
Repeatⁱ	618 – 772	CHCRPROSITE-ProRule annotationAdd BLAST		155

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	809 – 843	Sequence analysisAdd BLAST		35

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG2034 Eukaryota ENOG410XRSD LUCA
KEGG Orthology (KO) More...KOⁱ	K20181
OMAⁱ	DAWIEMG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01XI

Family and domain databases

InterProⁱ	View protein in InterPro IPR000547 Clathrin_H-chain/VPS_repeat IPR007810 Pep3_Vps18
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00637 Clathrin, 1 hit PF05131 Pep3_Vps18, 1 hit
PROSITEⁱ	View protein in PROSITE PS50236 CHCR, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A024R9R3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASILDEYEN SLSRSAVLQP GCPSVGIPHS GYVNAQLEKE VPIFTKQRID 
        60         70         80         90        100
FTPSERITSL VVSSNQLCMS LGKDTLLRID LGKANEPNHV ELGRKDDAKV 
       110        120        130        140        150
HKMFLDHTGS HLLIALSSTE VLYVNRNGQK VRPLARWKGQ LVESVGWNKA 
       160        170        180        190        200
LGTESSTGPI LVGTAQGHIF EAELSASEGG LFGPAPDLYF RPLYVLNEEG 
       210        220        230        240        250
GPAPVCSLEA ERGPDGRSFV IATTRQRLFQ FIGRAAEGAE AQGFSGLFAA 
       260        270        280        290        300
YTDHPPPFRE FPSNLGYSEL AFYTPKLRSA PRAFAWMMGD GVLYGALDCG 
       310        320        330        340        350
RPDSLLSEER VWEYPEGVGP GASPPLAIVL TQFHFLLLLA DRVEAVCTLT 
       360        370        380        390        400
GQVVLRDHFL EKFGPLKHMV KDSSTGQLWA YTERAVFRYH VQREARDVWR 
       410        420        430        440        450
TYLDMNRFDL AKEYCRERPD CLDTVLAREA DFCFRQRRYL ESARCYALTQ 
       460        470        480        490        500
SYFEEIALKF LEARQEEALA EFLQRKLASL KPAERTQATL LTTWLTELYL 
       510        520        530        540        550
SRLGALQGDP EALTLYRETK ECFRTFLSSP RHKEWLFASR ASIHELLASH 
       560        570        580        590        600
GDTEHMVYFA VIMQDYERVV AYHCQHEAYE EALAVLARHR DPQLFYKFSP 
       610        620        630        640        650
ILIRHIPRQL VDAWIEMGSR LDARQLIPAL VNYSQGGEVQ QVSQAIRYME 
       660        670        680        690        700
FCVNVLGETE QAIHNYLLSL YARGRPDSLL AYLEQAGASP HRVHYDLKYA 
       710        720        730        740        750
LRLCAEHGHH RACVHVYKVL ELYEEAVDLA LQVDVDLAKQ CADLPEEDEE 
       760        770        780        790        800
LRKKLWLKIA RHVVQEEEDV QTAMACLASC PLLKIEDVLP FFPDFVTIDH 
       810        820        830        840        850
FKEAICSSLK AYNHHIQELQ REMEEATASA QRIRRDLQEL RGRYGTVEPQ 
       860        870        880        890        900
DKCATCDFPL LNRPFYLFLC GHMFHADCLL QAVRPGLPAY KQARLEELQR 
       910        920        930        940        950
KLGAAPPPAK GSARAKEAEG GAATAGPSRE QLKADLDELV AAECVYCGEL 
       960        970 
MIRSIDRPFI DPQRYEEEQL SWL

Length:973

Mass (Da):110,186

Last modified:July 9, 2014 - v1

Checksum:ⁱ0008E21D66E8CFEC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471125 Genomic DNA Translation: EAW92464.1 CH471125 Genomic DNA Translation: EAW92465.1
NCBI Reference Sequences More...RefSeqⁱ	NP_065908.1, NM_020857.2
UniGeneⁱ	Hs.23876

Genome annotation databases

GeneIDⁱ	57617
KEGGⁱ	hsa:57617

Protein	Similar proteins		Species	Score	Length	Source
A0A024R9R3	Vacuolar protein sorting-associated protein 18 homolog		HUMAN		973	UniRef100_Q9P253
UPI0005D02D32		HUMAN		871
UPI0007DC789A		HUMAN		605

Protein	Similar proteins		Species	Score	Length	Source
A0A024R9R3	Vacuolar protein sorting-associated protein 18 homolog		HUMAN		973	UniRef90_Q9P253
Vacuolar protein sorting-associated protein 18 homolog		MOUSE		973
Vacuolar protein sorting-associated protein 18 homolog		HETGA		974
Vacuolar protein sorting-associated protein 18 like protein		FUKDA		974
Uncharacterized protein		CAVPO		974
+149

Protein	Similar proteins		Species	Score	Length	Source
A0A024R9R3	Vacuolar protein sorting-associated protein 18 homolog		HUMAN		973	UniRef50_Q9P253
Vacuolar protein sorting-associated protein 18 homolog		MOUSE		973
Uncharacterized protein		CAVPO		974
Vacuolar protein sorting-associated protein 18 homolog		HETGA		974
Vacuolar protein sorting-associated protein 18 like protein		FUKDA		974
+350

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471125 Genomic DNA Translation: EAW92464.1 CH471125 Genomic DNA Translation: EAW92465.1
RefSeqⁱ	NP_065908.1, NM_020857.2
UniGeneⁱ	Hs.23876

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	57617
KEGGⁱ	hsa:57617

Organism-specific databases

CTDⁱ	57617
EuPathDBⁱ	HostDB:ENSG00000104142.10

Phylogenomic databases

eggNOGⁱ	KOG2034 Eukaryota ENOG410XRSD LUCA
KOⁱ	K20181
OMAⁱ	DAWIEMG
OrthoDBⁱ	EOG091G01XI

Miscellaneous databases

ChiTaRSⁱ	VPS18 human
GenomeRNAiⁱ	57617

Gene expression databases

Bgeeⁱ	ENSG00000104142 Expressed in 181 organ(s), highest expression level in tendon of biceps brachii

Bgeeⁱ

ENSG00000104142 Expressed in 181 organ(s), highest expression level in tendon of biceps brachii

Family and domain databases

InterProⁱ	View protein in InterPro IPR000547 Clathrin_H-chain/VPS_repeat IPR007810 Pep3_Vps18
Pfamⁱ	View protein in Pfam PF00637 Clathrin, 1 hit PF05131 Pep3_Vps18, 1 hit
PROSITEⁱ	View protein in PROSITE PS50236 CHCR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A024R9R3_HUMAN
Accessionⁱ	A0A024R9R3Primary (citable) accession number: A0A024R9R3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 9, 2014
	Last sequence update:	July 9, 2014
	Last modified:	November 7, 2018
	This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - A0A024R9R3 (A0A024R9R3_HUMAN)

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Vacuolar protein sorting protein 18, isoform CRA_d

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

Cytoskeleton

Endosome

Other locations

Expressionⁱ

Gene expression databases

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

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Annotation systems

Supporting data

UniProtKB - A0A024R9R3 (A0A024R9R3_HUMAN)

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Vacuolar protein sorting protein 18, isoform CRA_d

VPS18

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Endosome

Other locations

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ