UniProtKB - A0A024R9R3 (A0A024R9R3_HUMAN)
Protein
Vacuolar protein sorting-associated protein 18 homolog
Gene
VPS18
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- endosome organization Source: Ensembl
- intracellular protein transport Source: UniProtKB-UniRule
- vesicle-mediated transport Source: InterPro
- viral entry into host cell Source: Ensembl
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 18 homologARBA annotation |
Gene namesi | Name:VPS18Imported ORF Names:hCG_38959Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000104142.10 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Cytoskeleton
- actin filament Source: Ensembl
Endosome
- CORVET complex Source: Ensembl
- early endosome Source: Ensembl
Other locations
- AP-3 adaptor complex Source: Ensembl
- presynapse Source: Ensembl
Keywords - Cellular componenti
MembraneARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000104142, Expressed in stomach and 199 other tissues |
ExpressionAtlasi | A0A024R9R3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 291 – 434 | Pep3_Vps18InterPro annotationAdd BLAST | 144 | |
Repeati | 618 – 772 | CHCRPROSITE-ProRule annotationAdd BLAST | 155 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 903 – 929 | DisorderedSequence analysisAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 809 – 843 | Sequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the VPS18 family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerARBA annotationPhylogenomic databases
HOGENOMi | CLU_003488_1_0_1 |
OMAi | EHCFQNK |
OrthoDBi | 87842at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000547, Clathrin_H-chain/VPS_repeat IPR007810, Pep3_Vps18 |
Pfami | View protein in Pfam PF00637, Clathrin, 1 hit PF05131, Pep3_Vps18, 1 hit |
PROSITEi | View protein in PROSITE PS50236, CHCR, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R9R3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASILDEYEN SLSRSAVLQP GCPSVGIPHS GYVNAQLEKE VPIFTKQRID
60 70 80 90 100
FTPSERITSL VVSSNQLCMS LGKDTLLRID LGKANEPNHV ELGRKDDAKV
110 120 130 140 150
HKMFLDHTGS HLLIALSSTE VLYVNRNGQK VRPLARWKGQ LVESVGWNKA
160 170 180 190 200
LGTESSTGPI LVGTAQGHIF EAELSASEGG LFGPAPDLYF RPLYVLNEEG
210 220 230 240 250
GPAPVCSLEA ERGPDGRSFV IATTRQRLFQ FIGRAAEGAE AQGFSGLFAA
260 270 280 290 300
YTDHPPPFRE FPSNLGYSEL AFYTPKLRSA PRAFAWMMGD GVLYGALDCG
310 320 330 340 350
RPDSLLSEER VWEYPEGVGP GASPPLAIVL TQFHFLLLLA DRVEAVCTLT
360 370 380 390 400
GQVVLRDHFL EKFGPLKHMV KDSSTGQLWA YTERAVFRYH VQREARDVWR
410 420 430 440 450
TYLDMNRFDL AKEYCRERPD CLDTVLAREA DFCFRQRRYL ESARCYALTQ
460 470 480 490 500
SYFEEIALKF LEARQEEALA EFLQRKLASL KPAERTQATL LTTWLTELYL
510 520 530 540 550
SRLGALQGDP EALTLYRETK ECFRTFLSSP RHKEWLFASR ASIHELLASH
560 570 580 590 600
GDTEHMVYFA VIMQDYERVV AYHCQHEAYE EALAVLARHR DPQLFYKFSP
610 620 630 640 650
ILIRHIPRQL VDAWIEMGSR LDARQLIPAL VNYSQGGEVQ QVSQAIRYME
660 670 680 690 700
FCVNVLGETE QAIHNYLLSL YARGRPDSLL AYLEQAGASP HRVHYDLKYA
710 720 730 740 750
LRLCAEHGHH RACVHVYKVL ELYEEAVDLA LQVDVDLAKQ CADLPEEDEE
760 770 780 790 800
LRKKLWLKIA RHVVQEEEDV QTAMACLASC PLLKIEDVLP FFPDFVTIDH
810 820 830 840 850
FKEAICSSLK AYNHHIQELQ REMEEATASA QRIRRDLQEL RGRYGTVEPQ
860 870 880 890 900
DKCATCDFPL LNRPFYLFLC GHMFHADCLL QAVRPGLPAY KQARLEELQR
910 920 930 940 950
KLGAAPPPAK GSARAKEAEG GAATAGPSRE QLKADLDELV AAECVYCGEL
960 970
MIRSIDRPFI DPQRYEEEQL SWL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471125 Genomic DNA Translation: EAW92464.1 CH471125 Genomic DNA Translation: EAW92465.1 |
RefSeqi | NP_065908.1, NM_020857.2 |
Genome annotation databases
GeneIDi | 57617 |
KEGGi | hsa:57617 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471125 Genomic DNA Translation: EAW92464.1 CH471125 Genomic DNA Translation: EAW92465.1 |
RefSeqi | NP_065908.1, NM_020857.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 23197, 142 antibodies |
Genome annotation databases
GeneIDi | 57617 |
KEGGi | hsa:57617 |
Organism-specific databases
CTDi | 57617 |
VEuPathDBi | HostDB:ENSG00000104142.10 |
Phylogenomic databases
HOGENOMi | CLU_003488_1_0_1 |
OMAi | EHCFQNK |
OrthoDBi | 87842at2759 |
Miscellaneous databases
BioGRID-ORCSi | 57617, 553 hits in 886 CRISPR screens |
ChiTaRSi | VPS18, human |
GenomeRNAii | 57617 |
Gene expression databases
Bgeei | ENSG00000104142, Expressed in stomach and 199 other tissues |
ExpressionAtlasi | A0A024R9R3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000547, Clathrin_H-chain/VPS_repeat IPR007810, Pep3_Vps18 |
Pfami | View protein in Pfam PF00637, Clathrin, 1 hit PF05131, Pep3_Vps18, 1 hit |
PROSITEi | View protein in PROSITE PS50236, CHCR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R9R3_HUMAN | |
Accessioni | A0A024R9R3Primary (citable) accession number: A0A024R9R3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 10, 2021 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |