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Protein
Submitted name:

Contactin 2 (Axonal), isoform CRA_a

Gene

CNTN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Contactin 2 (Axonal), isoform CRA_aImported
Gene namesi
Name:CNTN2Imported
ORF Names:hCG_16407Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000184144.9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_501001075831 – 1040Sequence analysisAdd BLAST1010

Proteomic databases

PRIDEiA0A024R9B4

Expressioni

Gene expression databases

BgeeiENSG00000184144 Expressed in 110 organ(s), highest expression level in corpus callosum
ExpressionAtlasiA0A024R9B4 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiA0A024R9B4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 128Ig-likeInterPro annotationAdd BLAST86
Domaini133 – 222Ig-likeInterPro annotationAdd BLAST90
Domaini239 – 322Ig-likeInterPro annotationAdd BLAST84
Domaini327 – 411Ig-likeInterPro annotationAdd BLAST85
Domaini417 – 504Ig-likeInterPro annotationAdd BLAST88
Domaini509 – 603Ig-likeInterPro annotationAdd BLAST95
Domaini610 – 708Fibronectin type-IIIInterPro annotationAdd BLAST99
Domaini713 – 810Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini815 – 910Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini915 – 1006Fibronectin type-IIIInterPro annotationAdd BLAST92

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
KOiK06760
OMAiIIPCQPR
OrthoDBiEOG091G00X7

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR032991 Contactin-2
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PANTHERiPTHR43905:SF1 PTHR43905:SF1, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits

Sequencei

Sequence statusi: Complete.

A0A024R9B4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTATRRKPH LLLVAAVALV SSSAWSSALG SQTTFGPVFE DQPLSVLFPE
60 70 80 90 100
ESTEEQVLLA CRARASPPAT YRWKMNGTEM KLEPGSRHQL VGGNLVIMNP
110 120 130 140 150
TKAQDAGVYQ CLASNPVGTV VSREAILRFG FLQEFSKEER DPVKAHEGWG
160 170 180 190 200
VMLPCNPPAH YPGLSYRWLL NEFPNFIPTD GRHFVSQTTG NLYIARTNAS
210 220 230 240 250
DLGNYSCLAT SHMDFSTKSV FSKFAQLNLA AEDTRLFAPS IKARFPAETY
260 270 280 290 300
ALVGQQVTLE CFAFGNPVPR IKWRKVDGSL SPQWTTAEPT LQIPSVSFED
310 320 330 340 350
EGTYECEAEN SKGRDTVQGR IIVQAQPEWL KVISDTEADI GSNLRWGCAA
360 370 380 390 400
AGKPRPTVRW LRNGEPLASQ NRVEVLAGDL RFSKLSLEDS GMYQCVAENK
410 420 430 440 450
HGTIYASAEL AVQALAPDFR LNPVRRLIPA ARGGEILIPC QPRAAPKAVV
460 470 480 490 500
LWSKGTEILV NSSRVTVTPD GTLIIRNISR SDEGKYTCFA ENFMGKANST
510 520 530 540 550
GILSVRDATK ITLAPSSADI NLGDNLTLQC HASHDPTMDL TFTWTLDDFP
560 570 580 590 600
IDFDKPGGHY RRTNVKETIG DLTILNAQLR HGGKYTCMAQ TVVDSASKEA
610 620 630 640 650
TVLVRGPPGP PGGVVVRDIG DTTIQLSWSR GFDNHSPIAK YTLQARTPPA
660 670 680 690 700
GKWKQVRTNP ANIEGNAETA QVLGLTPWMD YEFRVIASNI LGTGEPSGPS
710 720 730 740 750
SKIRTREAAP SVAPSGLSGG GGAPGELIVN WTPMSREYQN GDGFGYLLSF
760 770 780 790 800
RRQGSTHWQT ARVPGADAQY FVYSNESVRP YTPFEVKIRS YNRRGDGPES
810 820 830 840 850
LTALVYSAEE EPRVAPTKVW AKGVSSSEMN VTWEPVQQDM NGILLGYEIR
860 870 880 890 900
YWKAGDKEAA ADRVRTAGLD TSARVSGLHP NTKYHVTVRA YNRAGTGPAS
910 920 930 940 950
PSANATTMKP PPRRPPGNIS WTFSSSSLSI KWDPVVPFRN ESAVTGYKML
960 970 980 990 1000
YQNDLHLTPT LHLTGKNWIE IPVPEDIGHA LVQIRTTGPG GDGIPAEVHI
1010 1020 1030 1040
VRNGGTSMMV ENMAVRPAPH PGTVISHSVA MLILIGSLEL
Length:1,040
Mass (Da):113,393
Last modified:July 9, 2014 - v1
Checksum:i254E78DD3C28EFB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471067 Genomic DNA Translation: EAW91533.1
CH471067 Genomic DNA Translation: EAW91534.1
RefSeqiNP_001333012.1, NM_001346083.1
NP_005067.1, NM_005076.4
UniGeneiHs.519220

Genome annotation databases

GeneIDi6900
KEGGihsa:6900

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471067 Genomic DNA Translation: EAW91533.1
CH471067 Genomic DNA Translation: EAW91534.1
RefSeqiNP_001333012.1, NM_001346083.1
NP_005067.1, NM_005076.4
UniGeneiHs.519220

3D structure databases

SMRiA0A024R9B4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA0A024R9B4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6900
KEGGihsa:6900

Organism-specific databases

CTDi6900
EuPathDBiHostDB:ENSG00000184144.9

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
KOiK06760
OMAiIIPCQPR
OrthoDBiEOG091G00X7

Miscellaneous databases

ChiTaRSiCNTN2 human
GenomeRNAii6900

Gene expression databases

BgeeiENSG00000184144 Expressed in 110 organ(s), highest expression level in corpus callosum
ExpressionAtlasiA0A024R9B4 baseline and differential

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR032991 Contactin-2
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PANTHERiPTHR43905:SF1 PTHR43905:SF1, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R9B4_HUMAN
AccessioniPrimary (citable) accession number: A0A024R9B4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 7, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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