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Entry version 34 (26 Feb 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Laminin, gamma 1 (Formerly LAMB2), isoform CRA_a

Gene

LAMC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Laminin, gamma 1 (Formerly LAMB2), isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMC1Imported
ORF Names:hCG_40729Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi252 ↔ 269PROSITE-ProRule annotation
Disulfide bondi271 ↔ 280PROSITE-ProRule annotation
Disulfide bondi334 ↔ 343PROSITE-ProRule annotation
Disulfide bondi362 ↔ 374PROSITE-ProRule annotation
Disulfide bondi382 ↔ 391PROSITE-ProRule annotation
Disulfide bondi429 ↔ 438PROSITE-ProRule annotation
Disulfide bondi706 ↔ 715PROSITE-ProRule annotation
Disulfide bondi739 ↔ 756PROSITE-ProRule annotation
Disulfide bondi759 ↔ 768PROSITE-ProRule annotation
Disulfide bondi816 ↔ 825PROSITE-ProRule annotation
Disulfide bondi871 ↔ 880PROSITE-ProRule annotation
Disulfide bondi899 ↔ 911PROSITE-ProRule annotation
Disulfide bondi901 ↔ 918PROSITE-ProRule annotation
Disulfide bondi920 ↔ 929PROSITE-ProRule annotation
Disulfide bondi947 ↔ 959PROSITE-ProRule annotation
Disulfide bondi967 ↔ 976PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 249Laminin N-terminalInterPro annotationAdd BLAST240
Domaini250 – 305Laminin EGF-likeInterPro annotationAdd BLAST56
Domaini306 – 361Laminin EGF-likeInterPro annotationAdd BLAST56
Domaini362 – 408Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini409 – 458Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini485 – 653Laminin IV type AInterPro annotationAdd BLAST169
Domaini688 – 736Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini737 – 791Laminin EGF-likeInterPro annotationAdd BLAST55
Domaini792 – 847Laminin EGF-likeInterPro annotationAdd BLAST56
Domaini848 – 898Laminin EGF-likeInterPro annotationAdd BLAST51
Domaini899 – 946Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini947 – 994Laminin EGF-likeInterPro annotationAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1032 – 1059Sequence analysisAdd BLAST28
Coiled coili1064 – 1122Sequence analysisAdd BLAST59
Coiled coili1144 – 1164Sequence analysisAdd BLAST21
Coiled coili1193 – 1227Sequence analysisAdd BLAST35
Coiled coili1243 – 1291Sequence analysisAdd BLAST49
Coiled coili1299 – 1319Sequence analysisAdd BLAST21
Coiled coili1348 – 1368Sequence analysisAdd BLAST21
Coiled coili1383 – 1403Sequence analysisAdd BLAST21
Coiled coili1418 – 1452Sequence analysisAdd BLAST35
Coiled coili1508 – 1556Sequence analysisAdd BLAST49

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1836 Eukaryota
ENOG410XRDC LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 10 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 10 hits
SM00281 LamB, 1 hit
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 10 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R972-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDECTDEGGR PQRCMPEFVN AAFNVTVVAT NTCGTPPEEY CVQTGVTGVT
60 70 80 90 100
KSCHLCDAGQ PHLQHGAAFL TDYNNQADTT WWQSQTMLAG VQYPSSINLT
110 120 130 140 150
LHLGKAFDIT YVRLKFHTSR PESFAIYKRT REDGPWIPYQ YYSGSCENTY
160 170 180 190 200
SKANRGFIRT GGDEQQALCT DEFSDISPLT GGNVAFSTLE GRPSAYNFDN
210 220 230 240 250
SPVLQEWVTA TDIRVTLNRL NTFGDEVFND PKVLKSYYYA ISDFAVGGRC
260 270 280 290 300
KCNGHASECM KNEFDKLVCN CKHNTYGVDC EKCLPFFNDR PWRRATAESA
310 320 330 340 350
SECLPCDCNG RSQECYFDPE LYRSTGHGGH CTNCQDNTDG AHCERCRENF
360 370 380 390 400
FRLGNNEACS SCHCSPVGSL STQCDSYGRC SCKPGVMGDK CDRCQPGFHS
410 420 430 440 450
LTEAGCRPCS CDPSGSIDEC NIETGRCVCK DNVEGFNCER CKPGFFNLES
460 470 480 490 500
SNPRGCTPCF CFGHSSVCTN AVGYSVYSIS STFQIDEDGW RAEQRDGSEA
510 520 530 540 550
SLEWSSERQD IAVISDSYFP RYFIAPAKFL GKQVLSYGQN LSFSFRVDRR
560 570 580 590 600
DTRLSAEDLV LEGAGLRVSV PLIAQGNSYP SETTVKYVFR LHEATDYPWR
610 620 630 640 650
PALTPFEFQK LLNNLTSIKI RGTYSERSAG YLDDVTLASA RPGPGVPATW
660 670 680 690 700
VESCTCPVGY GGQFCEMCLS GYRRETPNLG PYSPCVLCAC NGHSETCDPE
710 720 730 740 750
TGVCNCRDNT AGPHCEKCSD GYYGDSTAGT SSDCQPCPCP GGSSCAVVPK
760 770 780 790 800
TKEVVCTNCP TGTTGKRCEL CDDGYFGDPL GRNGPVRLCR LCQCSDNIDP
810 820 830 840 850
NAVGNCNRLT GECLKCIYNT AGFYCDRCKD GFFGNPLAPN PADKCKACNC
860 870 880 890 900
NLYGTMKQQS SCNPVTGQCE CLPHVTGQDC GACDPGFYNL QSGQGCERCD
910 920 930 940 950
CHALGSTNGQ CDIRTGQCEC QPGITGQHCE RCEVNHFGFG PEGCKPCDCH
960 970 980 990 1000
PEGSLSLQCK DDGRCECREG FVGNRCDQCE ENYFYNRSWP GCQECPACYR
1010 1020 1030 1040 1050
LVKDKVADHR VKLQELESLI ANLGTGDEMV TDQAFEDRLK EAEREVMDLL
1060 1070 1080 1090 1100
REAQDVKDVD QNLMDRLQRV NNTLSSQISR LQNIRNTIEE TGNLAEQARA
1110 1120 1130 1140 1150
HVENTERLIE IASRELEKAK VAAANVSVTQ PESTGDPNNM TLLAEEARKL
1160 1170 1180 1190 1200
AERHKQEADD IVRVAKTAND TSTEAYNLLL RTLAGENQTA FEIEELNRKY
1210 1220 1230 1240 1250
EQAKNISQDL EKQAARVHEE AKRAGDKAVE IYASVAQLSP LDSETLENEA
1260 1270 1280 1290 1300
NNIKMEAENL EQLIDQKLKD YEDLREDMRG KELEVKNLLE KGKTEQQTAD
1310 1320 1330 1340 1350
QLLARADAAK ALAEEAAKKG RDTLQEANDI LNNLKDFDRR VNDNKTAAEE
1360 1370 1380 1390 1400
ALRKIPAINQ TITEANEKTR EAQQALGSAA ADATEAKNKA HEAERIASAV
1410 1420 1430 1440 1450
QKNATSTKAE AERTFAEVTD LDNEVNNMLK QLQEAEKELK RKQDDADQDM
1460 1470 1480 1490 1500
MMAGMASQAA QEAEINARKA KNSVTSLLSI INDLLEQLGQ LDTVDLNKLN
1510 1520 1530 1540 1550
EIEGTLNKAK DEMKVSDLDR KVSDLENEAK KQEAAIMDYN RDIEEIMKDI
1560 1570
RNLEDIRKTL PSGCFNTPSI EKP
Length:1,573
Mass (Da):174,012
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F477C51F02020CE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471067 Genomic DNA Translation: EAW91144.1
CH471067 Genomic DNA Translation: EAW91145.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471067 Genomic DNA Translation: EAW91144.1
CH471067 Genomic DNA Translation: EAW91145.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

eggNOGiKOG1836 Eukaryota
ENOG410XRDC LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LAMC1 human

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 10 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 10 hits
SM00281 LamB, 1 hit
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 10 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R972_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R972
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: February 26, 2020
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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