UniProtKB - A0A024R8L6 (A0A024R8L6_HUMAN)
Protein
Submitted name:
ATP-binding cassette, sub-family A (ABC1), member 8, isoform CRA_a
Gene
ABCA8
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 516 – 523 | ATPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1283 – 1290 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-UniRule
Keywordsi
Ligand | ATP-bindingPROSITE-ProRule annotationImportedARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: ATP-binding cassette, sub-family A (ABC1), member 8, isoform CRA_aImported |
Gene namesi | Name:ABCA8Imported ORF Names:hCG_28464Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000141338.13 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 224 – 244 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 265 – 288 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 294 – 320 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 332 – 353 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 359 – 377 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 397 – 419 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 822 – 839 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 981 – 1004 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 1024 – 1046 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1058 – 1083 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 1095 – 1117 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1124 – 1146 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1158 – 1180 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000141338, Expressed in corpus callosum and 236 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 480 – 675 | ABC transporterInterPro annotationAdd BLAST | 196 | |
Domaini | 1245 – 1478 | ABC transporterInterPro annotationAdd BLAST | 234 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisFamily and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR026082, ABCA IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 2 hits |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
A0A024R8L6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKRKISVCQ QTWALLCKNF LKKWRMKRES LMEWLNSLLL LLCLYIYPHS
60 70 80 90 100
HQVNDFSSLL TMDLGRVDTF NESRFSVVYT PVTNTTQQIM NKVASTPFLA
110 120 130 140 150
GKEVLGLPDE ESIKEFTANY PEEIVRVTFT NTYSYHLKFL LGHGMPAKKE
160 170 180 190 200
HKDHTAHCYE TNEDVYCEVS VFWKEGFVAL QAAINAAIIE ITTNHSVMEE
210 220 230 240 250
LMSVTGKNMK MHSFIGQSGV ITDLYLFSCI ISFSSFIYYA SVNVTRERKR
260 270 280 290 300
MKALMTMMGL RDSAFWLSWG LLYAGFIFIM ALFLALVIRS TQFIILSGFM
310 320 330 340 350
VVFSLFLLYG LSLVALAFLM SILVKKSFLT GLVVFLLTVF WGCLGFTSLY
360 370 380 390 400
RHLPASLEWI LSLLSPFAFM LGMAQLLHLD YDLNSNAFPH PSDGSNLIVA
410 420 430 440 450
TNFMLAFDTC LYLALAIYFE KILPNEYGHR RPPLFFLKSS FWSQTQKTDH
460 470 480 490 500
VALEDEMDAD PSFHDSFEQA PPEFQGKEAI RIRNVTKEYK GKPDKIEALK
510 520 530 540 550
DLVFDIYEGQ ITAILGHSGA GKSTLLNILS GLSVPTKGSV TIYNNKLSEM
560 570 580 590 600
ADLENLSKLT GVCPQSNVQF DFLTVRENLR LFAKIKGILP QEVDKEIFLL
610 620 630 640 650
DEPTAGLDPF SRHQVWNLLK ERKTDRVILF STQFMDEADI LADRKVFLSQ
660 670 680 690 700
GKLKCAGSSL FLKKKWGIGY HLSLQLNEIC VEENITSLVK QHIPDAKLSA
710 720 730 740 750
KSEGKLIYTL PLERTNKFPE LYKDLDSYPD LGIENYGVSM TTLNEVFLKL
760 770 780 790 800
EGKSTINESD IAILGEVQAE KADDTERLVE MEQVLSSLNK MRKTIGGVAL
810 820 830 840 850
WRQQICAIAR VRLLKLKHER KALLALLLIL MAGFCPLLVE YTMVKIYQNS
860 870 880 890 900
YTWELSPHLY FLAPGQQPHD PLTQLLIINK TGASIDDFIQ SVEHQNIALE
910 920 930 940 950
VDAFGTRNGT DDPSYNGAIT VCCNEKNYSF SLACNAKRLN CFPVLMDIVS
960 970 980 990 1000
NGLLGMVKPS VHIRTERSTF LENGQDNPIG FLAYIMFWLV LTSSCPPYIA
1010 1020 1030 1040 1050
MSSIDDYKNR ARSQLRISGL SPSAYWFGQA LVDVSLYFLV FVFIYLMSYI
1060 1070 1080 1090 1100
SNFEDMLLTI IHIIQIPCAV GYSFSLIFMT YVISFIFRKG RKNSGIWSFC
1110 1120 1130 1140 1150
FYVVTVFSVA GFAFSIFESD IPFIFTFLIP PATMIGCLFL SSHLLFSSLF
1160 1170 1180 1190 1200
SEERMDVQPF LVFLIPFLHF IIFLFTLRCL EWKFGKKSMR KDPFFRISPR
1210 1220 1230 1240 1250
SSDVCQNPEE PEGEDEDVQM ERVRTANALN STNFDEKPVI IASCLRKEYA
1260 1270 1280 1290 1300
GKRKGCFSKR KNKIATRNVS FCVRKGEVLG LLGHNGAGKS TSIKVITGDT
1310 1320 1330 1340 1350
KPTAGQVLLK GSGGGDALEF LGYCPQENAL WPNLTVRQHL EVYAAVKGLR
1360 1370 1380 1390 1400
KGDAEVAITR LVDALKLQDQ LKSPVKTLSE GIKRKLCFVL SILGNPSVVL
1410 1420 1430 1440 1450
LDEPSTGMDP EGQQQMWQAI RATFRNTERG ALLTTHYMAE AEAVCDRVAI
1460 1470 1480 1490 1500
MVSGRLRCIG SIQHLKSKFG KDYLLEMKVK NLAQVEPLHA EILRLFPQAA
1510 1520 1530 1540 1550
RQERYSSLMV YKLPVEDVQP LAQAFFKLEK VKQSFDLEEY SLSQSTLEQV
1560 1570 1580
FLELSKEQEL GDFEEDFDPS VKWKLLPQEE P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471099 Genomic DNA Translation: EAW89068.1 CH471099 Genomic DNA Translation: EAW89069.1 |
RefSeqi | NP_009099.1, NM_007168.3 |
Genome annotation databases
GeneIDi | 10351 |
KEGGi | hsa:10351 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471099 Genomic DNA Translation: EAW89068.1 CH471099 Genomic DNA Translation: EAW89069.1 |
RefSeqi | NP_009099.1, NM_007168.3 |
3D structure databases
SMRi | A0A024R8L6 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 31802, 130 antibodies |
Genome annotation databases
GeneIDi | 10351 |
KEGGi | hsa:10351 |
Organism-specific databases
CTDi | 10351 |
EuPathDBi | HostDB:ENSG00000141338.13 |
Miscellaneous databases
BioGRID-ORCSi | 10351, 4 hits in 845 CRISPR screens |
ChiTaRSi | ABCA8, human |
GenomeRNAii | 10351 |
Gene expression databases
Bgeei | ENSG00000141338, Expressed in corpus callosum and 236 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR026082, ABCA IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 2 hits |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R8L6_HUMAN | |
Accessioni | A0A024R8L6Primary (citable) accession number: A0A024R8L6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |