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Entry version 34 (02 Dec 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

HCG1987119, isoform CRA_a

Gene

hCG_1987119

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HCG1987119, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:hCG_1987119Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

A0A024R8L2
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-14103818,EBI-11096309
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-14103818,EBI-10173507
BHLHB9 [Q6PI77]3EBI-14103818,EBI-11519926
C11orf1 [Q9H5F2]3EBI-14103818,EBI-718615
CARD9 - isoform 2 [Q9H257-2]3EBI-14103818,EBI-11530605
CCNC [P24863]3EBI-14103818,EBI-395261
COIL [P38432]3EBI-14103818,EBI-945751
CRX [O43186]3EBI-14103818,EBI-748171
DUSP21 [Q9H596]3EBI-14103818,EBI-7357329
ERAS [Q7Z444]3EBI-14103818,EBI-13351543
FHL2 [Q14192]5EBI-14103818,EBI-701903
GAB2 [Q9UQC2]3EBI-14103818,EBI-975200
GADD45GIP1 [Q8TAE8]3EBI-14103818,EBI-372506
GINS3 [Q9BRX5]3EBI-14103818,EBI-2857315
HOXA1 [P49639]3EBI-14103818,EBI-740785
IHO1 [Q8IYA8]3EBI-14103818,EBI-8638439
IKZF3 [Q9UKT9]3EBI-14103818,EBI-747204
KATNBL1 [Q9H079]3EBI-14103818,EBI-715394
KCNJ6 [P48051]3EBI-14103818,EBI-12017638
KIAA0408 [Q6ZU52]3EBI-14103818,EBI-739493
KIF24 - isoform 2 [Q5T7B8-2]3EBI-14103818,EBI-10213781
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-14103818,EBI-14069005
KLF4 [O43474]3EBI-14103818,EBI-7232405
KLHL12 [Q53G59]3EBI-14103818,EBI-740929
KRT13 [P13646]3EBI-14103818,EBI-1223876
KRT34 [O76011]3EBI-14103818,EBI-1047093
KRT35 [Q92764]3EBI-14103818,EBI-1058674
KRT75 [O95678]3EBI-14103818,EBI-2949715
LIMS1 - isoform 3 [P48059-3]3EBI-14103818,EBI-12864460
MTUS2 - isoform 2 [Q5JR59-3]3EBI-14103818,EBI-11522433
MYOZ3 [Q8TDC0]3EBI-14103818,EBI-5662487
NADSYN1 [Q6IA69]6EBI-14103818,EBI-748610
NDUFA12 [Q9UI09]3EBI-14103818,EBI-1246332
NECAB2 - isoform 2 [Q7Z6G3-2]3EBI-14103818,EBI-10172876
NEDD4 - isoform 3 [P46934-3]3EBI-14103818,EBI-11980721
NEFL [P07196]3EBI-14103818,EBI-475646
NHSL2 [Q5HYW2]3EBI-14103818,EBI-2859639
NKAPD1 [Q6ZUT1]3EBI-14103818,EBI-3920396
NOTCH2NLC [P0DPK4]3EBI-14103818,EBI-22310682
NR1D2 [Q6NSM0]3EBI-14103818,EBI-10250949
NUP62 [P37198]3EBI-14103818,EBI-347978
PAK5 [Q9P286]3EBI-14103818,EBI-741896
PKNOX2 [Q96KN3]3EBI-14103818,EBI-2692890
PLEKHA3 [Q9HB20]3EBI-14103818,EBI-11079894
PNMA1 [Q8ND90]3EBI-14103818,EBI-302345
POU6F2 [P78424]3EBI-14103818,EBI-12029004
PPM1K [Q8N3J5]3EBI-14103818,EBI-3923368
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-14103818,EBI-12000762
PRKAR1B [P31321]3EBI-14103818,EBI-2805516
RBM11 [P57052]3EBI-14103818,EBI-741332
RCN1 [Q15293]3EBI-14103818,EBI-948278
RCN3 [Q96D15]3EBI-14103818,EBI-746283
REL - isoform 2 [Q04864-2]3EBI-14103818,EBI-10829018
RPH3AL [Q9UNE2]3EBI-14103818,EBI-2855824
SLA - isoform 3 [Q13239-3]3EBI-14103818,EBI-17630587
SORBS3 [O60504]3EBI-14103818,EBI-741237
SPATC1L - isoform 2 [Q9H0A9-2]3EBI-14103818,EBI-11995806
SPRED2 [Q7Z698]3EBI-14103818,EBI-7082156
SSBP4 [Q9BWG4]3EBI-14103818,EBI-744719
TCF12 - isoform 3 [Q99081-3]3EBI-14103818,EBI-11952764
TCF4 - isoform SEF2-1D [P15884-3]3EBI-14103818,EBI-13636688
TEX13A [Q9BXU3]3EBI-14103818,EBI-10301068
TFIP11 [Q9UBB9]3EBI-14103818,EBI-1105213
TPRN - isoform 2 [Q4KMQ1-2]3EBI-14103818,EBI-11978969
TRAF2 [Q12933]3EBI-14103818,EBI-355744
TRIM14 [Q14142]3EBI-14103818,EBI-2820256
TRIM27 [P14373]3EBI-14103818,EBI-719493
TRIM54 [Q9BYV2]3EBI-14103818,EBI-2130429
TSC22D4 [Q9Y3Q8]3EBI-14103818,EBI-739485
UBQLN2 [Q9UHD9]3EBI-14103818,EBI-947187
VGLL3 - isoform 2 [A8MV65-2]3EBI-14103818,EBI-11957216
ZBED1 [O96006]3EBI-14103818,EBI-740037
ZBTB10 - isoform 3 [Q96DT7-3]3EBI-14103818,EBI-12017160
ZBTB3 [Q9H5J0]3EBI-14103818,EBI-7229473
ZBTB32 [A0A0C4DGF1]3EBI-14103818,EBI-10188476
ZBTB8A [Q96BR9]3EBI-14103818,EBI-742740
ZCCHC14 [Q8WYQ9]3EBI-14103818,EBI-3937908
ZNF114 [Q8NC26]3EBI-14103818,EBI-10265237
ZNF438 [Q7Z4V0]3EBI-14103818,EBI-11962468
ZNF774 [Q6NX45]3EBI-14103818,EBI-10251462
ZNF837 [Q96EG3]3EBI-14103818,EBI-11962574

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A0A024R8L2, 81 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 180MyTH4InterPro annotationAdd BLAST147
Domaini186 – 487FERMInterPro annotationAdd BLAST302

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit
cd13201, FERM_C_MyoXV, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
1.25.40.530, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR041795, MyoXV_FERM_C
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00373, FERM_M, 1 hit
PF00784, MyTH4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit
SM00139, MyTH4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057, FERM_3, 1 hit
PS51016, MYTH4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R8L2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEFARRYFR RSQALLGQTD GGAAGKDTDS LVQYTKAPIQ ESLLSLSDDV
60 70 80 90 100
SKLAVASFLA LMRFMGDQSK PRGKDEMDLL YELLKLCQQE KLRDEIYCQV
110 120 130 140 150
IKQVTGHPRP EHCTRGWSFL SLLTGFFPPS TRLMPYLTKF LQDSGPSQEL
160 170 180 190 200
ARSSQEHLQR TVKYGGRRRM PPPGEMKAFL KGQAIRLLLI HLPGGVDYRT
210 220 230 240 250
NIQTFTVAAE VQEELCRQMG ITEPQEVQEF ALFLIKEKSQ LVRPLQPAEY
260 270 280 290 300
LNSVVVDQDV SLHSRRLHWE TPLHFDNSTY ISTHYSQVLW DYLQGKLPVS
310 320 330 340 350
AKADAQLARL AALQHLSKAN RNTPSGQDLL AYVPKQLQRQ VNTASIKNLM
360 370 380 390 400
GQELRRLEGH SPQEAQISFI EAMSQLPLFG YTVYGVLRVS MQALSGPTLL
410 420 430 440 450
GLNRQHLILM DPSSQSLYCR IALKSLQRLH LLSPLEEKGP PGLEVNYGSA
460 470 480
DNPQTIWFEL PQAQELLYTT VFLIDSSASC TEWPSIN
Length:487
Mass (Da):55,075
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8A6742DB739F39D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CH471099 Genomic DNA Translation: EAW89285.1
CH471099 Genomic DNA Translation: EAW89287.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471099 Genomic DNA Translation: EAW89285.1
CH471099 Genomic DNA Translation: EAW89287.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiA0A024R8L2, 81 interactors

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
cd13201, FERM_C_MyoXV, 1 hit
Gene3Di1.20.80.10, 1 hit
1.25.40.530, 1 hit
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR041795, MyoXV_FERM_C
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
PfamiView protein in Pfam
PF00373, FERM_M, 1 hit
PF00784, MyTH4, 1 hit
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM00139, MyTH4, 1 hit
SUPFAMiSSF47031, SSF47031, 1 hit
PROSITEiView protein in PROSITE
PS50057, FERM_3, 1 hit
PS51016, MYTH4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R8L2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R8L2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: December 2, 2020
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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