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UniProtKB - A0A024R8K7 (A0A024R8K7_HUMAN)

Entry version 52 (25 May 2022)
Sequence version 1 (09 Jul 2014)
Previous versions | rss
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Protein

Integrin beta

Gene

ITGB4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrinUniRule annotationARBA annotation, ReceptorARBA annotation
Biological processCell adhesionUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin betaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGB4Imported
ORF Names:hCG_27538Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000132470

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junctionARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500153318928 – 1752Integrin betaSequence analysisAdd BLAST1725

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132470, Expressed in tibial nerve and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A024R8K7, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A024R8K7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1129 – 1218Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1222 – 1321Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini1460 – 1555Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1573 – 1669Fibronectin type-IIIInterPro annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1113 – 1140DisorderedSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotationARBA annotation

Keywords - Domaini

RepeatARBA annotation, SignalSequence analysisARBA annotation, TransmembraneUniRule annotationARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_237558_0_0_1

Database of Orthologous Groups

More...OrthoDBi		473040at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 4 hits
2.60.40.2030, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR000742, EGF-like_dom
IPR013111, EGF_extracell
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR040622, I-EGF_1
IPR013783, Ig-like_fold
IPR033760, Integrin_beta_N
IPR015812, Integrin_bsu
IPR012013, Integrin_bsu-4
IPR012896, Integrin_bsu_tail
IPR036349, Integrin_bsu_tail_dom_sf
IPR002369, Integrin_bsu_VWA
IPR016201, PSI
IPR036465, vWFA_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR10082, PTHR10082, 2 hits
PTHR10082:SF42, PTHR10082:SF42, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03160, Calx-beta, 1 hit
PF07974, EGF_2, 1 hit
PF00041, fn3, 4 hits
PF18372, I-EGF_1, 1 hit
PF07965, Integrin_B_tail, 1 hit
PF00362, Integrin_beta, 1 hit
PF17205, PSI_integrin, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002513, Integrin_B4, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01186, INTEGRINB

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00237, Calx_beta, 1 hit
SM00060, FN3, 4 hits
SM00187, INB, 1 hit
SM01242, Integrin_B_tail, 1 hit
SM00423, PSI, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF141072, SSF141072, 1 hit
SSF49265, SSF49265, 2 hits
SSF53300, SSF53300, 1 hit
SSF69687, SSF69687, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 1 hit
PS50853, FN3, 4 hits
PS00243, INTEGRIN_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R8K7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPRPSPWA RLLLAALISV SLSGTLANRC KKAPVKSCTE CVRVDKDCAY 
        60         70         80         90        100
CTDEMFRDRR CNTQAELLAA GCQRESIVVM ESSFQITEET QIDTTLRRSQ 
       110        120        130        140        150
MSPQGLRVRL RPGEERHFEL EVFEPLESPV DLYILMDFSN SMSDDLDNLK 
       160        170        180        190        200
KMGQNLARVL SQLTSDYTIG FGKFVDKVSV PQTDMRPEKL KEPWPNSDPP 
       210        220        230        240        250
FSFKNVISLT EDVDEFRNKL QGERISGNLD APEGGFDAIL QTAVCTRDIG 
       260        270        280        290        300
WRPDSTHLLV FSTESAFHYE ADGANVLAGI MSRNDERCHL DTTGTYTQYR 
       310        320        330        340        350
TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHTYF PVSSLGVLQE 
       360        370        380        390        400
DSSNIVELLE EAFNRIRSNL DIRALDSPRG LRTEVTSKMF QKTRTGSFHI 
       410        420        430        440        450
RRGEVGIYQV QLRALEHVDG THVCQLPEDQ KGNIHLKPSF SDGLKMDAGI 
       460        470        480        490        500
ICDVCTCELQ KEVRSARCSF NGDFVCGQCV CSEGWSGQTC NCSTGSLSDI 
       510        520        530        540        550
QPCLREGEDK PCSGRGECQC GHCVCYGEGR YEGQFCEYDN FQCPRTSGFL 
       560        570        580        590        600
CNDRGRCSMG QCVCEPGWTG PSCDCPLSNA TCIDSNGGIC NGRGHCECGR 
       610        620        630        640        650
CHCHQQSLYT DTICEINYSA IHPGLCEDLR SCVQCQAWGT GEKKGRTCEE 
       660        670        680        690        700
CNFKVKMVDE LKRAEEVVVR CSFRDEDDDC TYSYTMEGDG APGPNSTVLV 
       710        720        730        740        750
HKKKDCPPGS FWWLIPLLLL LLPLLALLLL LCWKYCACCK ACLALLPCCN 
       760        770        780        790        800
RGHMVGFKED HYMLRENLMA SDHLDTPMLR SGNLKGRDVV RWKVTNNMQR 
       810        820        830        840        850
PGFATHAASI NPTELVPYGL SLRLARLCTE NLLKPDTREC AQLRQEVEEN 
       860        870        880        890        900
LNEVYRQISG VHKLQQTKFR QQPNAGKKQD HTIVDTVLMA PRSAKPALLK 
       910        920        930        940        950
LTEKQVEQRA FHDLKVAPGY YTLTADQDAR GMVEFQEGVE LVDVRVPLFI 
       960        970        980        990       1000
RPEDDDEKQL LVEAIDVPAG TATLGRRLVN ITIIKEQARD VVSFEQPEFS 
      1010       1020       1030       1040       1050
VSRGDQVARI PVIRRVLDGG KSQVSYRTQD GTAQGNRDYI PVEGELLFQP 
      1060       1070       1080       1090       1100
GEAWKELQVK LLELQEVDSL LRGRQVRRFH VQLSNPKFGA HLGQPHSTTI 
      1110       1120       1130       1140       1150
IIRDPDELDR SFTSQMLSSQ PPPHGDLGAP QNPNAKAAGS RKIHFNWLPP 
      1160       1170       1180       1190       1200
SGKPMGYRVK YWIQGDSESE AHLLDSKVPS VELTNLYPYC DYEMKVCAYG 
      1210       1220       1230       1240       1250
AQGEGPYSSL VSCRTHQEVP SEPGRLAFNV VSSTVTQLSW AEPAETNGEI 
      1260       1270       1280       1290       1300
TAYEVCYGLV NDDNRPIGPM KKVLVDNPKN RMLLIENLRE SQPYRYTVKA 
      1310       1320       1330       1340       1350
RNGAGWGPER EAIINLATQP KRPMSIPIIP DIPIVDAQSG EDYDSFLMYS 
      1360       1370       1380       1390       1400
DDVLRSPSGS QRPSVSDDTE HLVNGRMDFA FPGSTNSLHR MTTTSAAAYG 
      1410       1420       1430       1440       1450
THLSPHVPHR VLSTSSTLTR DYNSLTRSEH SHSTTLPRDY STLTSVSSHD 
      1460       1470       1480       1490       1500
SRLTAGVPDT PTRLVFSALG PTSLRVSWQE PRCERPLQGY SVEYQLLNGG 
      1510       1520       1530       1540       1550
ELHRLNIPNP AQTSVVVEDL LPNHSYVFRV RAQSQEGWGR EREGVITIES 
      1560       1570       1580       1590       1600
QVHPQSPLCP LPGSAFTLST PSAPGPLVFT ALSPDSLQLS WERPRRPNGD 
      1610       1620       1630       1640       1650
IVGYLVTCEM AQGGGPATAF RVDGDSPESR LTVPGLSENV PYKFKVQART 
      1660       1670       1680       1690       1700
TEGFGPEREG IITIESQDGG PFPQLGSRAG LFQHPLQSEY SSITTTHTSA 
      1710       1720       1730       1740       1750
TEPFLVDGLT LGAQHLEAGG SLTRHVTQEF VSRTLTTSGT LSTHMDQQFF 

QT
Length:1,752
Mass (Da):195,013
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C473AEFB8804093
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH471099 Genomic DNA Translation: EAW89308.1

NCBI Reference Sequences

More...RefSeqi		NP_001005731.1, NM_001005731.2
NP_001308052.1, NM_001321123.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3691

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471099 Genomic DNA Translation: EAW89308.1
RefSeqiNP_001005731.1, NM_001005731.2
NP_001308052.1, NM_001321123.1

3D structure databases

SMRiA0A024R8K7
ModBaseiSearch...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3934, 1064 antibodies from 44 providers

The DNASU plasmid repository

More...DNASUi		3691

Genome annotation databases

GeneIDi3691

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3691
VEuPathDBiHostDB:ENSG00000132470

Phylogenomic databases

HOGENOMiCLU_237558_0_0_1
OrthoDBi473040at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3691, 12 hits in 1080 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ITGB4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3691

Gene expression databases

BgeeiENSG00000132470, Expressed in tibial nerve and 228 other tissues
ExpressionAtlasiA0A024R8K7, baseline and differential

Family and domain databases

CDDicd00063, FN3, 4 hits
Gene3Di2.60.40.10, 4 hits
2.60.40.2030, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR000742, EGF-like_dom
IPR013111, EGF_extracell
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR040622, I-EGF_1
IPR013783, Ig-like_fold
IPR033760, Integrin_beta_N
IPR015812, Integrin_bsu
IPR012013, Integrin_bsu-4
IPR012896, Integrin_bsu_tail
IPR036349, Integrin_bsu_tail_dom_sf
IPR002369, Integrin_bsu_VWA
IPR016201, PSI
IPR036465, vWFA_dom_sf
PANTHERiPTHR10082, PTHR10082, 2 hits
PTHR10082:SF42, PTHR10082:SF42, 2 hits
PfamiView protein in Pfam
PF03160, Calx-beta, 1 hit
PF07974, EGF_2, 1 hit
PF00041, fn3, 4 hits
PF18372, I-EGF_1, 1 hit
PF07965, Integrin_B_tail, 1 hit
PF00362, Integrin_beta, 1 hit
PF17205, PSI_integrin, 1 hit
PIRSFiPIRSF002513, Integrin_B4, 2 hits
PRINTSiPR01186, INTEGRINB
SMARTiView protein in SMART
SM00237, Calx_beta, 1 hit
SM00060, FN3, 4 hits
SM00187, INB, 1 hit
SM01242, Integrin_B_tail, 1 hit
SM00423, PSI, 1 hit
SUPFAMiSSF141072, SSF141072, 1 hit
SSF49265, SSF49265, 2 hits
SSF53300, SSF53300, 1 hit
SSF69687, SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS50853, FN3, 4 hits
PS00243, INTEGRIN_BETA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R8K7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R8K7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: May 25, 2022
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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