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UniProtKB - A0A024R8K7 (A0A024R8K7_HUMAN)
Protein
Integrin beta
Gene
ITGB4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- cell-matrix adhesion Source: InterPro
- cell motility Source: InterPro
- hemidesmosome assembly Source: InterPro
- integrin-mediated signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | IntegrinUniRule annotationARBA annotation, ReceptorARBA annotation |
Biological process | Cell adhesionUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Integrin betaUniRule annotation |
Gene namesi | Name:ITGB4Imported ORF Names:hCG_27538Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000132470 |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Single-pass type I membrane protein UniRule annotationARBA annotation
Nucleus
- nuclear membrane Source: HPA
- nucleolus Source: HPA
Plasma Membrane
- integrin complex Source: InterPro
- plasma membrane Source: HPA
Other locations
- cell junction Source: HPA
Keywords - Cellular componenti
Cell junctionARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_5001533189 | 28 – 1752 | Integrin betaSequence analysisAdd BLAST | 1725 |
Keywords - PTMi
GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000132470, Expressed in tibial nerve and 228 other tissues |
ExpressionAtlasi | A0A024R8K7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1129 – 1218 | Fibronectin type-IIIInterPro annotationAdd BLAST | 90 | |
Domaini | 1222 – 1321 | Fibronectin type-IIIInterPro annotationAdd BLAST | 100 | |
Domaini | 1460 – 1555 | Fibronectin type-IIIInterPro annotationAdd BLAST | 96 | |
Domaini | 1573 – 1669 | Fibronectin type-IIIInterPro annotationAdd BLAST | 97 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1113 – 1140 | DisorderedSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysisARBA annotation, TransmembraneUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_237558_0_0_1 |
OrthoDBi | 473040at2759 |
Family and domain databases
CDDi | cd00063, FN3, 4 hits |
Gene3Di | 2.60.40.10, 4 hits 2.60.40.2030, 1 hit 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR038081, CalX-like_sf IPR003644, Calx_beta IPR000742, EGF-like_dom IPR013111, EGF_extracell IPR003961, FN3_dom IPR036116, FN3_sf IPR040622, I-EGF_1 IPR013783, Ig-like_fold IPR033760, Integrin_beta_N IPR015812, Integrin_bsu IPR012013, Integrin_bsu-4 IPR012896, Integrin_bsu_tail IPR036349, Integrin_bsu_tail_dom_sf IPR002369, Integrin_bsu_VWA IPR016201, PSI IPR036465, vWFA_dom_sf |
PANTHERi | PTHR10082, PTHR10082, 2 hits PTHR10082:SF42, PTHR10082:SF42, 2 hits |
Pfami | View protein in Pfam PF03160, Calx-beta, 1 hit PF07974, EGF_2, 1 hit PF00041, fn3, 4 hits PF18372, I-EGF_1, 1 hit PF07965, Integrin_B_tail, 1 hit PF00362, Integrin_beta, 1 hit PF17205, PSI_integrin, 1 hit |
PIRSFi | PIRSF002513, Integrin_B4, 2 hits |
PRINTSi | PR01186, INTEGRINB |
SMARTi | View protein in SMART SM00237, Calx_beta, 1 hit SM00060, FN3, 4 hits SM00187, INB, 1 hit SM01242, Integrin_B_tail, 1 hit SM00423, PSI, 1 hit |
SUPFAMi | SSF141072, SSF141072, 1 hit SSF49265, SSF49265, 2 hits SSF53300, SSF53300, 1 hit SSF69687, SSF69687, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS50853, FN3, 4 hits PS00243, INTEGRIN_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R8K7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGPRPSPWA RLLLAALISV SLSGTLANRC KKAPVKSCTE CVRVDKDCAY
60 70 80 90 100
CTDEMFRDRR CNTQAELLAA GCQRESIVVM ESSFQITEET QIDTTLRRSQ
110 120 130 140 150
MSPQGLRVRL RPGEERHFEL EVFEPLESPV DLYILMDFSN SMSDDLDNLK
160 170 180 190 200
KMGQNLARVL SQLTSDYTIG FGKFVDKVSV PQTDMRPEKL KEPWPNSDPP
210 220 230 240 250
FSFKNVISLT EDVDEFRNKL QGERISGNLD APEGGFDAIL QTAVCTRDIG
260 270 280 290 300
WRPDSTHLLV FSTESAFHYE ADGANVLAGI MSRNDERCHL DTTGTYTQYR
310 320 330 340 350
TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHTYF PVSSLGVLQE
360 370 380 390 400
DSSNIVELLE EAFNRIRSNL DIRALDSPRG LRTEVTSKMF QKTRTGSFHI
410 420 430 440 450
RRGEVGIYQV QLRALEHVDG THVCQLPEDQ KGNIHLKPSF SDGLKMDAGI
460 470 480 490 500
ICDVCTCELQ KEVRSARCSF NGDFVCGQCV CSEGWSGQTC NCSTGSLSDI
510 520 530 540 550
QPCLREGEDK PCSGRGECQC GHCVCYGEGR YEGQFCEYDN FQCPRTSGFL
560 570 580 590 600
CNDRGRCSMG QCVCEPGWTG PSCDCPLSNA TCIDSNGGIC NGRGHCECGR
610 620 630 640 650
CHCHQQSLYT DTICEINYSA IHPGLCEDLR SCVQCQAWGT GEKKGRTCEE
660 670 680 690 700
CNFKVKMVDE LKRAEEVVVR CSFRDEDDDC TYSYTMEGDG APGPNSTVLV
710 720 730 740 750
HKKKDCPPGS FWWLIPLLLL LLPLLALLLL LCWKYCACCK ACLALLPCCN
760 770 780 790 800
RGHMVGFKED HYMLRENLMA SDHLDTPMLR SGNLKGRDVV RWKVTNNMQR
810 820 830 840 850
PGFATHAASI NPTELVPYGL SLRLARLCTE NLLKPDTREC AQLRQEVEEN
860 870 880 890 900
LNEVYRQISG VHKLQQTKFR QQPNAGKKQD HTIVDTVLMA PRSAKPALLK
910 920 930 940 950
LTEKQVEQRA FHDLKVAPGY YTLTADQDAR GMVEFQEGVE LVDVRVPLFI
960 970 980 990 1000
RPEDDDEKQL LVEAIDVPAG TATLGRRLVN ITIIKEQARD VVSFEQPEFS
1010 1020 1030 1040 1050
VSRGDQVARI PVIRRVLDGG KSQVSYRTQD GTAQGNRDYI PVEGELLFQP
1060 1070 1080 1090 1100
GEAWKELQVK LLELQEVDSL LRGRQVRRFH VQLSNPKFGA HLGQPHSTTI
1110 1120 1130 1140 1150
IIRDPDELDR SFTSQMLSSQ PPPHGDLGAP QNPNAKAAGS RKIHFNWLPP
1160 1170 1180 1190 1200
SGKPMGYRVK YWIQGDSESE AHLLDSKVPS VELTNLYPYC DYEMKVCAYG
1210 1220 1230 1240 1250
AQGEGPYSSL VSCRTHQEVP SEPGRLAFNV VSSTVTQLSW AEPAETNGEI
1260 1270 1280 1290 1300
TAYEVCYGLV NDDNRPIGPM KKVLVDNPKN RMLLIENLRE SQPYRYTVKA
1310 1320 1330 1340 1350
RNGAGWGPER EAIINLATQP KRPMSIPIIP DIPIVDAQSG EDYDSFLMYS
1360 1370 1380 1390 1400
DDVLRSPSGS QRPSVSDDTE HLVNGRMDFA FPGSTNSLHR MTTTSAAAYG
1410 1420 1430 1440 1450
THLSPHVPHR VLSTSSTLTR DYNSLTRSEH SHSTTLPRDY STLTSVSSHD
1460 1470 1480 1490 1500
SRLTAGVPDT PTRLVFSALG PTSLRVSWQE PRCERPLQGY SVEYQLLNGG
1510 1520 1530 1540 1550
ELHRLNIPNP AQTSVVVEDL LPNHSYVFRV RAQSQEGWGR EREGVITIES
1560 1570 1580 1590 1600
QVHPQSPLCP LPGSAFTLST PSAPGPLVFT ALSPDSLQLS WERPRRPNGD
1610 1620 1630 1640 1650
IVGYLVTCEM AQGGGPATAF RVDGDSPESR LTVPGLSENV PYKFKVQART
1660 1670 1680 1690 1700
TEGFGPEREG IITIESQDGG PFPQLGSRAG LFQHPLQSEY SSITTTHTSA
1710 1720 1730 1740 1750
TEPFLVDGLT LGAQHLEAGG SLTRHVTQEF VSRTLTTSGT LSTHMDQQFF
QT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471099 Genomic DNA Translation: EAW89308.1 |
RefSeqi | NP_001005731.1, NM_001005731.2 NP_001308052.1, NM_001321123.1 |
Genome annotation databases
GeneIDi | 3691 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471099 Genomic DNA Translation: EAW89308.1 |
RefSeqi | NP_001005731.1, NM_001005731.2 NP_001308052.1, NM_001321123.1 |
3D structure databases
SMRi | A0A024R8K7 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 3934, 1064 antibodies from 44 providers |
DNASUi | 3691 |
Genome annotation databases
GeneIDi | 3691 |
Organism-specific databases
CTDi | 3691 |
VEuPathDBi | HostDB:ENSG00000132470 |
Phylogenomic databases
HOGENOMi | CLU_237558_0_0_1 |
OrthoDBi | 473040at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3691, 12 hits in 1080 CRISPR screens |
ChiTaRSi | ITGB4, human |
GenomeRNAii | 3691 |
Gene expression databases
Bgeei | ENSG00000132470, Expressed in tibial nerve and 228 other tissues |
ExpressionAtlasi | A0A024R8K7, baseline and differential |
Family and domain databases
CDDi | cd00063, FN3, 4 hits |
Gene3Di | 2.60.40.10, 4 hits 2.60.40.2030, 1 hit 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR038081, CalX-like_sf IPR003644, Calx_beta IPR000742, EGF-like_dom IPR013111, EGF_extracell IPR003961, FN3_dom IPR036116, FN3_sf IPR040622, I-EGF_1 IPR013783, Ig-like_fold IPR033760, Integrin_beta_N IPR015812, Integrin_bsu IPR012013, Integrin_bsu-4 IPR012896, Integrin_bsu_tail IPR036349, Integrin_bsu_tail_dom_sf IPR002369, Integrin_bsu_VWA IPR016201, PSI IPR036465, vWFA_dom_sf |
PANTHERi | PTHR10082, PTHR10082, 2 hits PTHR10082:SF42, PTHR10082:SF42, 2 hits |
Pfami | View protein in Pfam PF03160, Calx-beta, 1 hit PF07974, EGF_2, 1 hit PF00041, fn3, 4 hits PF18372, I-EGF_1, 1 hit PF07965, Integrin_B_tail, 1 hit PF00362, Integrin_beta, 1 hit PF17205, PSI_integrin, 1 hit |
PIRSFi | PIRSF002513, Integrin_B4, 2 hits |
PRINTSi | PR01186, INTEGRINB |
SMARTi | View protein in SMART SM00237, Calx_beta, 1 hit SM00060, FN3, 4 hits SM00187, INB, 1 hit SM01242, Integrin_B_tail, 1 hit SM00423, PSI, 1 hit |
SUPFAMi | SSF141072, SSF141072, 1 hit SSF49265, SSF49265, 2 hits SSF53300, SSF53300, 1 hit SSF69687, SSF69687, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS50853, FN3, 4 hits PS00243, INTEGRIN_BETA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R8K7_HUMAN | |
Accessioni | A0A024R8K7Primary (citable) accession number: A0A024R8K7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | May 25, 2022 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |