UniProtKB - A0A024R8I1 (A0A024R8I1_HUMAN)
Protein
Voltage-dependent N-type calcium channel subunit alpha
Gene
CACNA1B
Organism
Homo sapiens (Human)
Status
Functioni
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.UniRule annotation
GO - Molecular functioni
- voltage-gated calcium channel activity Source: InterPro
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent N-type calcium channel subunit alphaUniRule annotation |
Gene namesi | Name:CACNA1BImported ORF Names:hCG_2021733Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- voltage-gated calcium channel complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 99 – 116 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 136 – 156 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 223 – 245 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 333 – 355 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 484 – 504 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 510 – 527 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 548 – 566 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 609 – 631 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 687 – 709 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
GlycoproteinARBA annotation, PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | A0A024R8I1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 95 – 366 | Ion_transInterPro annotationAdd BLAST | 272 | |
Domaini | 482 – 718 | Ion_transInterPro annotationAdd BLAST | 237 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 37 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 816 – 1005 | DisorderedSequence analysisAdd BLAST | 190 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 363 – 383 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 712 – 738 | Sequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 858 – 953 | PolyampholyteSequence analysisAdd BLAST | 96 |
Sequence similaritiesi
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationFamily and domain databases
Gene3Di | 1.20.120.350, 2 hits |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR005447, VDCC_N_a1su IPR002077, VDCCAlpha1 IPR043203, VGCC_Ca_Na IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR10037, PTHR10037, 1 hit PTHR10037:SF289, PTHR10037:SF289, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 2 hits |
PRINTSi | PR00167, CACHANNEL PR01631, NVDCCALPHA1 |
i Sequence
Sequence statusi: Complete.
A0A024R8I1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRFGDELGG RYGGPGGGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA
60 70 80 90 100
QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM
110 120 130 140 150
ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKII
160 170 180 190 200
ALGFVFHKGS YLRNGWKVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL
210 220 230 240 250
KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH
260 270 280 290 300
KACFPNSTDA EPVGDFPCGK EAPARLCEGD TECREYWPGP NFGITNFDNI
310 320 330 340 350
LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL
360 370 380 390 400
VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML
410 420 430 440 450
AEEDRNAEEK SPLDVLKRAA TKKSRNDLIH AEEGEDRFAD LCAVGSPFAR
460 470 480 490 500
ASLKSGKTES SSYFRRKEKM FRFFIRRMVK AQSFYWVVLC VVALNTLCVA
510 520 530 540 550
MVHYNQPRRL TTTLYFAEFV FLGLFLTEMS LKMYGLGPRS YFRSSFNCFD
560 570 580 590 600
FGVIVGSVFE VVWAAIKPGS SFGISVLRAL RLLRIFKVTK YWSSLRNLVV
610 620 630 640 650
SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP
660 670 680 690 700
AAILTVFQIL TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL
710 720 730 740 750
LNVFLAIAVD NLANAQELTK DEEEMEEAAN QKLALQKAKE VAEVSPMSAA
760 770 780 790 800
NISIAARQQN SAKARSVWEQ RASQLRLQNL RASCEALYSE MDPEERLRFA
810 820 830 840 850
TTRHLRPDMK THLDRPLVVE LGRDGARGPV GGKARPEAAE APEGVDPPRR
860 870 880 890 900
HHRHRDKDKT PAAGDQDRAE APKAESGEPG AREERPRPHR SHSKEAAGPP
910 920 930 940 950
EARSERGRGP GPEGGRRHHR RGSPEEAAER EPRRHRAHRH QDPSKESPRQ
960 970 980 990 1000
GRAARAAPRR PPSGAPGGGE RGGAGAAAPG PAQGAACSRG CGEGDHGEGG
HGEGG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471090 Genomic DNA Translation: EAW88415.1 CH471090 Genomic DNA Translation: EAW88416.1 CH471090 Genomic DNA Translation: EAW88417.1 CH471090 Genomic DNA Translation: EAW88418.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471090 Genomic DNA Translation: EAW88415.1 CH471090 Genomic DNA Translation: EAW88416.1 CH471090 Genomic DNA Translation: EAW88417.1 CH471090 Genomic DNA Translation: EAW88418.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
DrugBanki | DB00381, Amlodipine DB00996, Gabapentin |
Proteomic databases
PeptideAtlasi | A0A024R8I1 |
Miscellaneous databases
ChiTaRSi | CACNA1B, human |
Family and domain databases
Gene3Di | 1.20.120.350, 2 hits |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR005447, VDCC_N_a1su IPR002077, VDCCAlpha1 IPR043203, VGCC_Ca_Na IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR10037, PTHR10037, 1 hit PTHR10037:SF289, PTHR10037:SF289, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 2 hits |
PRINTSi | PR00167, CACHANNEL PR01631, NVDCCALPHA1 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R8I1_HUMAN | |
Accessioni | A0A024R8I1Primary (citable) accession number: A0A024R8I1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 10, 2021 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |