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Entry version 26 (12 Aug 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Nucleoporin 214kDa, isoform CRA_b

Gene

NUP214

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nucleoporin 214kDa, isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP214Imported
ORF Names:hCG_30191Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A024R8B6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1957 – 2018Nup214_FGInterPro annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni463 – 501DisorderedSequence analysisAdd BLAST39
Regioni530 – 577DisorderedSequence analysisAdd BLAST48
Regioni598 – 620DisorderedSequence analysisAdd BLAST23
Regioni638 – 741DisorderedSequence analysisAdd BLAST104
Regioni1028 – 1050DisorderedSequence analysisAdd BLAST23
Regioni1170 – 1193DisorderedSequence analysisAdd BLAST24
Regioni1209 – 1254DisorderedSequence analysisAdd BLAST46
Regioni1275 – 1357DisorderedSequence analysisAdd BLAST83
Regioni1378 – 1449DisorderedSequence analysisAdd BLAST72
Regioni1479 – 1508DisorderedSequence analysisAdd BLAST30
Regioni1520 – 1580DisorderedSequence analysisAdd BLAST61
Regioni1925 – 1944DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili744 – 764Sequence analysisAdd BLAST21
Coiled coili906 – 926Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi468 – 488PolarSequence analysisAdd BLAST21
Compositional biasi530 – 556PolarSequence analysisAdd BLAST27
Compositional biasi638 – 662PolarSequence analysisAdd BLAST25
Compositional biasi676 – 705PolarSequence analysisAdd BLAST30
Compositional biasi1170 – 1190PolarSequence analysisAdd BLAST21
Compositional biasi1275 – 1299PolarSequence analysisAdd BLAST25
Compositional biasi1312 – 1354PolarSequence analysisAdd BLAST43
Compositional biasi1380 – 1413PolarSequence analysisAdd BLAST34
Compositional biasi1427 – 1449PolarSequence analysisAdd BLAST23
Compositional biasi1520 – 1540PolarSequence analysisAdd BLAST21
Compositional biasi1555 – 1580PolarSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026054, Nucleoporin
IPR041553, Nup214_FG
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23193, PTHR23193, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18617, Nup214_FG, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R8B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGQLRAAGA EGRKFAVERP GFRGQGRGRQ RWLLRHTEGG AMGDEMDAMI
60 70 80 90 100
PEREMKDFQF RALKKVRIFD SPEELPKERS SLLAVSNKYG LVFAGGASGL
110 120 130 140 150
QIFPTKNLLI QNKPGDDPNK IVDKVQGLLV PMKFPIHHLA LSCDNLTLSA
160 170 180 190 200
CMMSSEYGSI IAFFDVRTFS NEAKQQKRPF AYHKLLKDAG GMVIDMKWNP
210 220 230 240 250
TVPSMVAVCL ADGSIAVLQV TETVKVCATL PSTVAVTSVC WSPKGKQLAV
260 270 280 290 300
GKQNGTVVQY LPTLQEKKVI PCPPFYESDH PVRVLDVLWI GTYVFAIVYA
310 320 330 340 350
AADGTLETSP DVVMALLPKK EEKHPEIFVN FMEPCYGSCT ERQHHYYLSY
360 370 380 390 400
IEEWDLVLAA SAASTEVSIL ARQSDQINWE SWLLEDSSRA ELPVTDKSDD
410 420 430 440 450
SLPMGVVVDY TNQVEITISD EKTLPPAPVL MLLSTDGVLC PFYMINQNPG
460 470 480 490 500
VKSLIKTPER LSLEGERQPK SPGSTPTTPT SSQAPQKLDA SAAAAPASLP
510 520 530 540 550
PSSPAAPIAT FSLLPAGGAP TVFSFGSSSL KSSATVTGEP PSYSSGSDSS
560 570 580 590 600
KAAPGPGPST FSFVPPSKAS LAPTPAASPV APSAASFSFG SSGFKPTLES
610 620 630 640 650
TPVPSVSAPN IAMKSSFPPS TSAVKVNLSE KFTAAATSTP VSSSQSAPPM
660 670 680 690 700
SPFSSASKPA ASGPLSHPTP LSAPPSSVPL KSSVLPSPSG RSAQGSSSPV
710 720 730 740 750
PSMVQKSPRI TPPAAKPGSP QAKSLQPAVA EKQGHQWKDS DPVMAGIGEE
760 770 780 790 800
IAHFQKELEE LKARTSKACF QVGTSEEMKM LRTESDDLHT FLLEIKETTE
810 820 830 840 850
SLHGDISSLK TTLLEGFAGV EEAREQNERN RDSGYLHLLY KRPLDPKSEA
860 870 880 890 900
QLQEIRRLHQ YVKFAVQDVN DVLDLEWDQH LEQKKKQRHL LVPERETLFN
910 920 930 940 950
TLANNREIIN QQRKRLNHLV DSLQQLRLYK QTSLWSLSSA VPSQSSIHSF
960 970 980 990 1000
DSDLESLCNA LLKTTIESHT KSLPKVPAKL SPMKQAQLRN FLAKRKTPPV
1010 1020 1030 1040 1050
RSTAPASLSR SAFLSQRYYE DLDEVSSTSS VSQSLESEDA RTSCKDDEAV
1060 1070 1080 1090 1100
VQAPRHAPVV RTPSIQPSLL PHAAPFAKSH LVHGSSPGVM GTSVATSASK
1110 1120 1130 1140 1150
IIPQGADSTM LATKTVKHGA PSPSHPISAP QAAAAAALRR QMASQAPAVN
1160 1170 1180 1190 1200
TLTESTLKNV PQVVNVQELK NNPATPSTAM GSSVPYSTAK TPHPVLTPVA
1210 1220 1230 1240 1250
ANQAKQGSLI NSLKPSGPTP ASGQLSSGDK ASGTAKIETA VTSTPSASGQ
1260 1270 1280 1290 1300
FSKPFSFSPS GTGFNFGIIT PTPSSNFTAA QGATPSTKES SQPDAFSSGG
1310 1320 1330 1340 1350
GSKPSYEAIP ESSPPSGITS ASNTTPGEPA ASSSRPVAPS GTALSTTSSK
1360 1370 1380 1390 1400
LETPPSKLGE LLFPSSLAGE TLGSFSGLRV GQADDSTKPT NKASSTSLTS
1410 1420 1430 1440 1450
TQPTKTSGVP SGFNFTAPPV LGKHTEPPVT SSATTTSVAP PAATSTSSTA
1460 1470 1480 1490 1500
VFGSLPVTSA GSSGVISFGG TSLSAGKTSF SFGSQQTNST VPPSAPPPTT
1510 1520 1530 1540 1550
AATPLPTSFP TLSFGSLLSS ATTPSLPMSA GRSTEEATSS ALPEKPGDSE
1560 1570 1580 1590 1600
VSASAASLLE EQQSAQLPQA PPQTSDSVKK EPVLAQPAVS NSGTAASSTS
1610 1620 1630 1640 1650
LVALSAEATP ATTGVPDART EAVPPASSFS VPGQTAVTAA AISSAGPVAV
1660 1670 1680 1690 1700
ETSSTPIASS TTSIVAPGPS AEAAAFGTVT SGSSVFAQPP AASSSSAFNQ
1710 1720 1730 1740 1750
LTNNTATAPS ATPVFGQVAA STAPSLFGQQ TGSTASTAAA TPQVSSSGFS
1760 1770 1780 1790 1800
SPAFGTTAPG VFGQTTFGQA SVFGQSASSA ASVFSFSQPG FSSVPAFGQP
1810 1820 1830 1840 1850
ASSTPTSTSG SVFGAASSTS SSSSFSFGQS SPNTGGGLFG QSNAPAFGQS
1860 1870 1880 1890 1900
PGFGQGGSVF GGTSAATTTA ATSGFSFCQA SGFGSSNTGS VFGQAASTGG
1910 1920 1930 1940 1950
IVFGQQSSSS SGSVFGSGNT GRGGGFFSGL GGKPSQDAAN KNPFSSASGG
1960 1970 1980 1990 2000
FGSTATSNTS NLFGNSGAKT FGGFASSSFG EQKPTGTFSS GGGSVASQGF
2010 2020 2030 2040 2050
GFSSPNKTGG FGAAPVFGSP PTFGGSPGFG GVPAFGSAPA FTSPLGSTGG
2060 2070 2080 2090 2100
KVFGEGTAAA SAGGFGFGSS SNTTSFGTLA SQNAPTFGSL SQQTSGFGTQ
2110 2120 2130
SSGFSGFGSG TGGFSFGSNN SSVQGFGGWR S
Length:2,131
Mass (Da):218,170
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB61D4D6088B904AF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471090 Genomic DNA Translation: EAW87961.1
CH471090 Genomic DNA Translation: EAW87962.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471090 Genomic DNA Translation: EAW87961.1
CH471090 Genomic DNA Translation: EAW87962.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA0A024R8B6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NUP214, human

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR026054, Nucleoporin
IPR041553, Nup214_FG
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
PANTHERiPTHR23193, PTHR23193, 1 hit
PfamiView protein in Pfam
PF18617, Nup214_FG, 1 hit
SMARTiView protein in SMART
SM00320, WD40, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R8B6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R8B6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: August 12, 2020
This is version 26 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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