UniProtKB - A0A024R8B2 (A0A024R8B2_HUMAN)
Protein
Submitted name:
Frequenin homolog (Drosophila), isoform CRA_a
Gene
FREQ
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 73 – 84 | PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 109 – 120 | PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 157 – 168 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: Ensembl
- magnesium ion binding Source: Ensembl
- protein kinase binding Source: Ensembl
- voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels Source: Ensembl
GO - Biological processi
- phosphatidylinositol-mediated signaling Source: Ensembl
- positive regulation of exocytosis Source: Ensembl
- regulation of neuron projection development Source: Ensembl
- regulation of synaptic vesicle exocytosis Source: Ensembl
Keywordsi
Ligand | CalciumPROSITE-ProRule annotationARBA annotation, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Frequenin homolog (Drosophila), isoform CRA_aImported |
Gene namesi | Name:FREQImported ORF Names:hCG_1784948Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000107130.9 |
Subcellular locationi
Cytosol
- postsynaptic cytosol Source: Ensembl
- presynaptic cytosol Source: Ensembl
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- calyx of Held Source: Ensembl
- dendrite Source: Ensembl
- dense core granule Source: Ensembl
- glutamatergic synapse Source: Ensembl
- intracellular membrane-bounded organelle Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000107130, Expressed in dorsolateral prefrontal cortex and 196 other tissues |
ExpressionAtlasi | A0A024R8B2, baseline and differential |
Interactioni
GO - Molecular functioni
- protein kinase binding Source: Ensembl
Chemistry databases
BindingDBi | A0A024R8B2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 60 – 95 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 96 – 131 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 144 – 179 | EF-handInterPro annotationAdd BLAST | 36 |
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
HOGENOMi | CLU_072366_1_2_1 |
OMAi | NMDRDKD |
OrthoDBi | 1369072at2759 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 3 hits |
i Sequence
Sequence statusi: Complete.
A0A024R8B2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKSNSKLKP EVVEELTRKT YFTEKEVQQW YKGFIKDCPS GQLDAAGFQK
60 70 80 90 100
IYKQFFPFGD PTKFATFVFN VFDENKDGRI EFSEFIQALS VTSRGTLDEK
110 120 130 140 150
LRWAFKLYDL DNDGYITRNE MLDIVDAIYQ MVGNTVELPE EENTPEKRVD
160 170 180 190
RIFAMMDKNA DGKLTLQEFQ EGSKADPSIV QALSLYDGLV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471090 Genomic DNA Translation: EAW87926.1 CH471090 Genomic DNA Translation: EAW87927.1 |
RefSeqi | NP_055101.2, NM_014286.3 |
Genome annotation databases
GeneIDi | 23413 |
KEGGi | hsa:23413 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471090 Genomic DNA Translation: EAW87926.1 CH471090 Genomic DNA Translation: EAW87927.1 |
RefSeqi | NP_055101.2, NM_014286.3 |
3D structure databases
SMRi | A0A024R8B2 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024R8B2 |
Protocols and materials databases
Antibodypediai | 4347, 353 antibodies |
Genome annotation databases
GeneIDi | 23413 |
KEGGi | hsa:23413 |
Organism-specific databases
CTDi | 23413 |
VEuPathDBi | HostDB:ENSG00000107130.9 |
Phylogenomic databases
HOGENOMi | CLU_072366_1_2_1 |
OMAi | NMDRDKD |
OrthoDBi | 1369072at2759 |
Miscellaneous databases
BioGRID-ORCSi | 23413, 3 hits in 872 CRISPR screens |
ChiTaRSi | NCS1, human |
GenomeRNAii | 23413 |
Gene expression databases
Bgeei | ENSG00000107130, Expressed in dorsolateral prefrontal cortex and 196 other tissues |
ExpressionAtlasi | A0A024R8B2, baseline and differential |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R8B2_HUMAN | |
Accessioni | A0A024R8B2Primary (citable) accession number: A0A024R8B2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 10, 2021 | |
This is version 55 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |