UniProtKB - A0A024R8A9 (A0A024R8A9_HUMAN)
Protein
Ubiquitin carboxyl-terminal hydrolase
Gene
USP20
Organism
Homo sapiens (Human)
Status
Functioni
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.UniRule annotation
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotationSAAS annotation EC:3.4.19.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 31 – 95 | UBP-typePROSITE-ProRule annotationAdd BLAST | 65 |
GO - Molecular functioni
- thiol-dependent ubiquitin-specific protease activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- protein deubiquitination Source: UniProtKB-UniRule
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseUniRule annotationSAAS annotation |
Biological process | Ubl conjugation pathwayUniRule annotationSAAS annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation) |
Gene namesi | Name:USP20Imported ORF Names:hCG_31247Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 95 | UBP-typeInterPro annotationAdd BLAST | 65 | |
Domaini | 148 – 687 | USPInterPro annotationAdd BLAST | 540 | |
Domaini | 689 – 782 | DUSPInterPro annotationAdd BLAST | 94 | |
Domaini | 791 – 894 | DUSPInterPro annotationAdd BLAST | 104 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 260 – 350 | DisorderedSequence analysisAdd BLAST | 91 | |
Regioni | 362 – 417 | DisorderedSequence analysisAdd BLAST | 56 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 265 – 292 | PolyampholyteSequence analysisAdd BLAST | 28 | |
Compositional biasi | 320 – 338 | PolyampholyteSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 31 – 95 | UBP-typePROSITE-ProRule annotationAdd BLAST | 65 |
Keywords - Domaini
Zinc-fingerSAAS annotationPhylogenomic databases
eggNOGi | KOG1870 Eukaryota COG5560 LUCA |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR035927 DUSP-like_sf IPR038765 Papain-like_cys_pep_sf IPR006615 Pept_C19_DUSP IPR001394 Peptidase_C19_UCH IPR018200 USP_CS IPR028889 USP_dom IPR013083 Znf_RING/FYVE/PHD IPR001607 Znf_UBP |
Pfami | View protein in Pfam PF06337 DUSP, 2 hits PF00443 UCH, 1 hit PF02148 zf-UBP, 1 hit |
SMARTi | View protein in SMART SM00695 DUSP, 2 hits SM00290 ZnF_UBP, 1 hit |
SUPFAMi | SSF143791 SSF143791, 2 hits SSF54001 SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS51283 DUSP, 2 hits PS00972 USP_1, 1 hit PS00973 USP_2, 1 hit PS50235 USP_3, 1 hit PS50271 ZF_UBP, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R8A9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARMGDSRDL CPHLDSIGEV TKEDLLLKSK GTCQSCGVTG PNLWACLQVA
60 70 80 90 100
CPYVGCGESF ADHSTIHAQA KKHNLTVNLT TFRLWCYACE KEVFLEQRLA
110 120 130 140 150
APLLGSSSKF SEQDSPPPSH PLKAVPIAVA DEGESESEDD DLKPRGLTGM
160 170 180 190 200
KNLGNSCYMN AALQALSNCP PLTQFFLECG GLVRTDKKPA LCKSYQKLVS
210 220 230 240 250
EVWHKKRPSY VVPTSLSHGI KLVNPMFRGY AQQDTQEFLR CLMDQLHEEL
260 270 280 290 300
KEPVVATVAL TEARDSDSSD TDEKREGDRS PSEDEFLSCD SSSDRGEGDG
310 320 330 340 350
QGRGGGSSQA ETELLIPDEA GRAISEKERM KDRKFSWGQQ RTNSEQVDED
360 370 380 390 400
ADVDTAMAAL DQPAEAQPPS PRSSSPCRTP EPDNDAHLRS SSRPCSPVHH
410 420 430 440 450
HEGHAKLSSS PPRASPVRMA PSYVLKKAQV LSAGSRRRKE QRYRSVISDI
460 470 480 490 500
FDGSILSLVQ CLTCDRVSTT VETFQDLSLP IPGKEDLAKL HSAIYQNVPA
510 520 530 540 550
KPGACGDSYA AQGWLAFIVE YIRRFVVSCT PSWFWGPVVT LEDCLAAFFA
560 570 580 590 600
ADELKGDNMY SCERCKKLRN GVKYCKVLRL PEILCIHLKR FRHEVMYSFK
610 620 630 640 650
INSHVSFPLE GLDLRPFLAK ECTSQITTYD LLSVICHHGT AGSGHYIAYC
660 670 680 690 700
QNVINGQWYE FDDQYVTEVH ETVVQNAEGY VLFYRKSSEE AMRERQQVVS
710 720 730 740 750
LAAMREPSLL RFYVSREWLN KFNTFAEPGP ITNQTFLCSH GGIPPHKYHY
760 770 780 790 800
IDDLVVILPQ NVWEHLYNRF GGGPAVNHLY VCSICQVEIE ALAKRRRIEI
810 820 830 840 850
DTFIKLNKAF QAEESPGVIY CISMQWFREW EAFVKGKDNE PPGPIDNSRI
860 870 880 890 900
AQVKGSGHVQ LKQGADYGQI SEETWTYLNS LYGGGPEIAI RQSVAQPLGP
910
ENLHGEQKIE AETRAV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471090 Genomic DNA Translation: EAW87911.1 CH471090 Genomic DNA Translation: EAW87912.1 CH471090 Genomic DNA Translation: EAW87913.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471090 Genomic DNA Translation: EAW87911.1 CH471090 Genomic DNA Translation: EAW87912.1 CH471090 Genomic DNA Translation: EAW87913.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A0A024R8A9, 36 interactors |
Proteomic databases
PeptideAtlasi | A0A024R8A9 |
Phylogenomic databases
eggNOGi | KOG1870 Eukaryota COG5560 LUCA |
Miscellaneous databases
ChiTaRSi | USP20 human |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR035927 DUSP-like_sf IPR038765 Papain-like_cys_pep_sf IPR006615 Pept_C19_DUSP IPR001394 Peptidase_C19_UCH IPR018200 USP_CS IPR028889 USP_dom IPR013083 Znf_RING/FYVE/PHD IPR001607 Znf_UBP |
Pfami | View protein in Pfam PF06337 DUSP, 2 hits PF00443 UCH, 1 hit PF02148 zf-UBP, 1 hit |
SMARTi | View protein in SMART SM00695 DUSP, 2 hits SM00290 ZnF_UBP, 1 hit |
SUPFAMi | SSF143791 SSF143791, 2 hits SSF54001 SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS51283 DUSP, 2 hits PS00972 USP_1, 1 hit PS00973 USP_2, 1 hit PS50235 USP_3, 1 hit PS50271 ZF_UBP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R8A9_HUMAN | |
Accessioni | A0A024R8A9Primary (citable) accession number: A0A024R8A9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | October 16, 2019 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |