Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - A0A024R8A9 (A0A024R8A9_HUMAN)

Entry version 52 (07 Apr 2021)
Sequence version 1 (09 Jul 2014)
Previous versions | rss
Add a publicationFeedback
Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

USP20

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotationARBA annotation EC:3.4.19.12

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri31 – 95UBP-typePROSITE-ProRule annotationAdd BLAST65

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseUniRule annotationARBA annotation
Biological processEndocytosisARBA annotation, Ubl conjugation pathwayUniRule annotationARBA annotation
LigandMetal-binding, Zinc

Protein family/group databases

MEROPS protease database

More...MEROPSi		C19.025

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP20Imported
ORF Names:hCG_31247Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
A0A024R8A9
With#Exp.IntAct
AGR2 [O95994]3EBI-14096082,EBI-712648
APBA2 - isoform 2 [Q99767-2]3EBI-14096082,EBI-12218351
ARID5A [Q03989]3EBI-14096082,EBI-948603
ASCL1 [P50553]3EBI-14096082,EBI-957042
ATP6V1G2 [O95670]3EBI-14096082,EBI-348290
BEND7 - isoform 2 [Q8N7W2-2]5EBI-14096082,EBI-10181188
BHLHB9 [Q6PI77]3EBI-14096082,EBI-11519926
BRPF1 - isoform 2 [P55201-2]3EBI-14096082,EBI-12065306
C1QTNF2 [Q9BXJ5]3EBI-14096082,EBI-2817707
CCNL2 - isoform 5 [Q96S94-5]3EBI-14096082,EBI-12024864
CDK2AP1 [O14519]3EBI-14096082,EBI-1052532
CTAG1B [P78358]3EBI-14096082,EBI-1188472
ENKD1 [Q9H0I2]3EBI-14096082,EBI-744099
EPAS1 [Q99814]3EBI-14096082,EBI-447470
FATE1 [Q969F0]3EBI-14096082,EBI-743099
FTO - isoform 2 [Q9C0B1-2]3EBI-14096082,EBI-18138793
GPRASP2 [Q96D09]3EBI-14096082,EBI-473189
HAND2 - isoform 2 [P61296-2]3EBI-14096082,EBI-13086076
HSF2BP [O75031]3EBI-14096082,EBI-7116203
IHO1 [Q8IYA8]3EBI-14096082,EBI-8638439
IRAK1BP1 [Q5VVH5]3EBI-14096082,EBI-9658404
ITGB3BP [Q13352]3EBI-14096082,EBI-712105
KLHL20 [Q9BS75]3EBI-14096082,EBI-10693436
MBD3L1 [Q8WWY6]3EBI-14096082,EBI-12516603
MCCD1 [P59942]3EBI-14096082,EBI-11987923
MDFI [Q99750]3EBI-14096082,EBI-724076
MEOX2 [Q6FHY5]3EBI-14096082,EBI-16439278
MRPL28 [Q13084]3EBI-14096082,EBI-723426
PBX4 [Q9BYU1]3EBI-14096082,EBI-10302990
RSPO4 [Q2I0M5]3EBI-14096082,EBI-12821217
SAMD12 [Q8N8I0]3EBI-14096082,EBI-12965130
SRGAP2B [A0A286YEY3]3EBI-14096082,EBI-17766455
TNNI1 [P19237]3EBI-14096082,EBI-746692
TRIB3 [Q96RU7]3EBI-14096082,EBI-492476
TTC19 [Q6DKK2]3EBI-14096082,EBI-948354
TTC23L [Q6PF05]3EBI-14096082,EBI-8656864
VAPA [Q9P0L0]3EBI-14096082,EBI-1059156
VAPB [O95292]3EBI-14096082,EBI-1188298
VAX1 - isoform 2 [Q5SQQ9-2]3EBI-14096082,EBI-12227803
ZBTB10 - isoform 3 [Q96DT7-3]3EBI-14096082,EBI-12017160
ZFYVE26 - isoform 5 [Q68DK2-5]3EBI-14096082,EBI-8656416
ZNF343 [Q6P1L6]3EBI-14096082,EBI-10252492
ZNF408 [Q9H9D4]3EBI-14096082,EBI-347633
ZNF620 [Q6ZNG0]3EBI-14096082,EBI-4395669
ZXDB [P98169]3EBI-14096082,EBI-17493569

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A0A024R8A9, 45 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 95UBP-typeInterPro annotationAdd BLAST65
Domaini148 – 687USPInterPro annotationAdd BLAST540
Domaini689 – 782DUSPInterPro annotationAdd BLAST94
Domaini791 – 894DUSPInterPro annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni260 – 350DisorderedSequence analysisAdd BLAST91
Regioni362 – 417DisorderedSequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi265 – 292PolyampholyteSequence analysisAdd BLAST28
Compositional biasi320 – 338PolyampholyteSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri31 – 95UBP-typePROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		TRDICPH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035927, DUSP-like_sf
IPR038765, Papain-like_cys_pep_sf
IPR006615, Pept_C19_DUSP
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom
IPR013083, Znf_RING/FYVE/PHD
IPR001607, Znf_UBP

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06337, DUSP, 2 hits
PF00443, UCH, 1 hit
PF02148, zf-UBP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00695, DUSP, 2 hits
SM00290, ZnF_UBP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF143791, SSF143791, 2 hits
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51283, DUSP, 2 hits
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit
PS50271, ZF_UBP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R8A9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARMGDSRDL CPHLDSIGEV TKEDLLLKSK GTCQSCGVTG PNLWACLQVA 
        60         70         80         90        100
CPYVGCGESF ADHSTIHAQA KKHNLTVNLT TFRLWCYACE KEVFLEQRLA 
       110        120        130        140        150
APLLGSSSKF SEQDSPPPSH PLKAVPIAVA DEGESESEDD DLKPRGLTGM 
       160        170        180        190        200
KNLGNSCYMN AALQALSNCP PLTQFFLECG GLVRTDKKPA LCKSYQKLVS 
       210        220        230        240        250
EVWHKKRPSY VVPTSLSHGI KLVNPMFRGY AQQDTQEFLR CLMDQLHEEL 
       260        270        280        290        300
KEPVVATVAL TEARDSDSSD TDEKREGDRS PSEDEFLSCD SSSDRGEGDG 
       310        320        330        340        350
QGRGGGSSQA ETELLIPDEA GRAISEKERM KDRKFSWGQQ RTNSEQVDED 
       360        370        380        390        400
ADVDTAMAAL DQPAEAQPPS PRSSSPCRTP EPDNDAHLRS SSRPCSPVHH 
       410        420        430        440        450
HEGHAKLSSS PPRASPVRMA PSYVLKKAQV LSAGSRRRKE QRYRSVISDI 
       460        470        480        490        500
FDGSILSLVQ CLTCDRVSTT VETFQDLSLP IPGKEDLAKL HSAIYQNVPA 
       510        520        530        540        550
KPGACGDSYA AQGWLAFIVE YIRRFVVSCT PSWFWGPVVT LEDCLAAFFA 
       560        570        580        590        600
ADELKGDNMY SCERCKKLRN GVKYCKVLRL PEILCIHLKR FRHEVMYSFK 
       610        620        630        640        650
INSHVSFPLE GLDLRPFLAK ECTSQITTYD LLSVICHHGT AGSGHYIAYC 
       660        670        680        690        700
QNVINGQWYE FDDQYVTEVH ETVVQNAEGY VLFYRKSSEE AMRERQQVVS 
       710        720        730        740        750
LAAMREPSLL RFYVSREWLN KFNTFAEPGP ITNQTFLCSH GGIPPHKYHY 
       760        770        780        790        800
IDDLVVILPQ NVWEHLYNRF GGGPAVNHLY VCSICQVEIE ALAKRRRIEI 
       810        820        830        840        850
DTFIKLNKAF QAEESPGVIY CISMQWFREW EAFVKGKDNE PPGPIDNSRI 
       860        870        880        890        900
AQVKGSGHVQ LKQGADYGQI SEETWTYLNS LYGGGPEIAI RQSVAQPLGP 
       910 
ENLHGEQKIE AETRAV
Length:916
Mass (Da):102,246
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78A332A292B5E16D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH471090 Genomic DNA Translation: EAW87911.1
CH471090 Genomic DNA Translation: EAW87912.1
CH471090 Genomic DNA Translation: EAW87913.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471090 Genomic DNA Translation: EAW87911.1
CH471090 Genomic DNA Translation: EAW87912.1
CH471090 Genomic DNA Translation: EAW87913.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiA0A024R8A9, 45 interactors

Protein family/group databases

MEROPSiC19.025

Phylogenomic databases

OMAiTRDICPH

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		USP20, human

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035927, DUSP-like_sf
IPR038765, Papain-like_cys_pep_sf
IPR006615, Pept_C19_DUSP
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom
IPR013083, Znf_RING/FYVE/PHD
IPR001607, Znf_UBP
PfamiView protein in Pfam
PF06337, DUSP, 2 hits
PF00443, UCH, 1 hit
PF02148, zf-UBP, 1 hit
SMARTiView protein in SMART
SM00695, DUSP, 2 hits
SM00290, ZnF_UBP, 1 hit
SUPFAMiSSF143791, SSF143791, 2 hits
SSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51283, DUSP, 2 hits
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit
PS50271, ZF_UBP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R8A9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R8A9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: April 7, 2021
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again