UniProtKB - A0A024R845 (A0A024R845_HUMAN)
Protein
Ras-related protein Rab-14
Gene
RAB14
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- defense response to bacterium Source: InterPro
- endocytic recycling Source: InterPro
- fibroblast growth factor receptor signaling pathway Source: Ensembl
- Golgi to endosome transport Source: Ensembl
- phagosome maturation Source: InterPro
- regulation of embryonic development Source: Ensembl
Keywordsi
Ligand | GTP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-14ARBA annotation |
Gene namesi | Name:RAB14Imported ORF Names:hCG_30332Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000119396.10 |
Subcellular locationi
Endosome
- Early endosome membrane ARBA annotation; Lipid-anchor ARBA annotation; Cytoplasmic side ARBA annotation
- Endosome membrane ARBA annotation; Lipid-anchor ARBA annotation; Cytoplasmic side ARBA annotation
- Recycling endosome ARBA annotation
Golgi apparatus
- Golgi apparatus membrane ARBA annotation; Lipid-anchor ARBA annotation; Cytoplasmic side ARBA annotation
- trans-Golgi network membrane ARBA annotation; Lipid-anchor ARBA annotation; Cytoplasmic side ARBA annotation
Other locations
- phagosome ARBA annotation
Cytosol
- cytosol Source: GOC
Endosome
- early endosome membrane Source: UniProtKB-SubCell
- recycling endosome Source: UniProtKB-SubCell
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
- trans-Golgi network Source: InterPro
Other locations
- intracellular membrane-bounded organelle Source: HPA
- phagocytic vesicle Source: UniProtKB-SubCell
Keywords - Cellular componenti
MembraneARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000119396, Expressed in upper lobe of lung and 258 other tissues |
ExpressionAtlasi | A0A024R845, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 188 – 215 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 125 – 145 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
OMAi | QRDVTFE |
OrthoDBi | 1146851at2759 |
PhylomeDBi | A0A024R845 |
Family and domain databases
CDDi | cd04122, Rab14, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR030702, Rab14 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
PANTHERi | PTHR24073:SF1098, PTHR24073:SF1098, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R845-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATAPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT
60 70 80 90 100
RIIEVSGQKI KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN
110 120 130 140 150
HLSSWLTDAR NLTNPNTVII LIGNKADLEA QRDVTYEEAK QFAEENGLLF
160 170 180 190 200
LEASAKTGEN VEDAFLEAAK KIYQNIQDGS LDLNAAESGV QHKPSAPQGG
210
RLTSEPQPQR EGCGC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471090 Genomic DNA Translation: EAW87488.1 |
RefSeqi | NP_057406.2, NM_016322.3 |
Genome annotation databases
GeneIDi | 51552 |
KEGGi | hsa:51552 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471090 Genomic DNA Translation: EAW87488.1 |
RefSeqi | NP_057406.2, NM_016322.3 |
3D structure databases
SMRi | A0A024R845 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A0A024R845, 1 interactor |
Protocols and materials databases
Antibodypediai | 15967, 159 antibodies |
Genome annotation databases
GeneIDi | 51552 |
KEGGi | hsa:51552 |
Organism-specific databases
CTDi | 51552 |
EuPathDBi | HostDB:ENSG00000119396.10 |
Phylogenomic databases
OMAi | QRDVTFE |
OrthoDBi | 1146851at2759 |
PhylomeDBi | A0A024R845 |
Miscellaneous databases
BioGRID-ORCSi | 51552, 37 hits in 826 CRISPR screens |
ChiTaRSi | RAB14, human |
GenomeRNAii | 51552 |
Gene expression databases
Bgeei | ENSG00000119396, Expressed in upper lobe of lung and 258 other tissues |
ExpressionAtlasi | A0A024R845, baseline and differential |
Family and domain databases
CDDi | cd04122, Rab14, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR030702, Rab14 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
PANTHERi | PTHR24073:SF1098, PTHR24073:SF1098, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R845_HUMAN | |
Accessioni | A0A024R845Primary (citable) accession number: A0A024R845 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |