Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 38 (08 May 2019)
Sequence version 1 (09 Jul 2014)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Zinc finger protein 43 (HTF6), isoform CRA_a

Gene

ZNF43

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein 43 (HTF6), isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF43Imported
ORF Names:hCG_36737Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A0A024R7P7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198521 Expressed in 226 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A024R7P7 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A024R7P7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 69KRABInterPro annotationAdd BLAST69
Domaini168 – 191C2H2-typeInterPro annotationAdd BLAST24
Domaini196 – 223C2H2-typeInterPro annotationAdd BLAST28
Domaini224 – 251C2H2-typeInterPro annotationAdd BLAST28
Domaini252 – 279C2H2-typeInterPro annotationAdd BLAST28
Domaini280 – 307C2H2-typeInterPro annotationAdd BLAST28
Domaini308 – 335C2H2-typeInterPro annotationAdd BLAST28
Domaini336 – 363C2H2-typeInterPro annotationAdd BLAST28
Domaini364 – 391C2H2-typeInterPro annotationAdd BLAST28
Domaini392 – 419C2H2-typeInterPro annotationAdd BLAST28
Domaini420 – 447C2H2-typeInterPro annotationAdd BLAST28
Domaini448 – 475C2H2-typeInterPro annotationAdd BLAST28
Domaini476 – 503C2H2-typeInterPro annotationAdd BLAST28
Domaini504 – 531C2H2-typeInterPro annotationAdd BLAST28
Domaini532 – 559C2H2-typeInterPro annotationAdd BLAST28
Domaini560 – 587C2H2-typeInterPro annotationAdd BLAST28
Domaini588 – 615C2H2-typeInterPro annotationAdd BLAST28
Domaini616 – 643C2H2-typeInterPro annotationAdd BLAST28
Domaini644 – 671C2H2-typeInterPro annotationAdd BLAST28
Domaini672 – 699C2H2-typeInterPro annotationAdd BLAST28
Domaini700 – 727C2H2-typeInterPro annotationAdd BLAST28
Domaini728 – 755C2H2-typeInterPro annotationAdd BLAST28
Domaini756 – 783C2H2-typeInterPro annotationAdd BLAST28

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 22 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 22 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R7P7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVAIEFCLE EWQCLDIAQQ NLYRNVMLEN YRNLVFLGIA VSKPDLITCL
60 70 80 90 100
EQEKEPWEPM RRHEMVAKPP VMCSHFTQDF WPEQHIKDPF QKATLRRYKN
110 120 130 140 150
CEHKNVHLKK DHKSVDECKV HRGGYNGFNQ CLPATQSKIF LFDKCVKAFH
160 170 180 190 200
KFSNSNRHKI SHTEKKLFKC KECGKSFCML PHLAQHKIIH TRVNFCKCEK
210 220 230 240 250
CGKAFNCPSI ITKHKRINTG EKPYTCEECG KVFNWSSRLT THKKNYTRYK
260 270 280 290 300
LYKCEECGKA FNKSSILTTH KIIRTGEKFY KCKECAKAFN QSSNLTEHKK
310 320 330 340 350
IHPGEKPYKC EECGKAFNWP STLTKHKRIH TGEKPYTCEE CGKAFNQFSN
360 370 380 390 400
LTTHKRIHTA EKFYKCTECG EAFSRSSNLT KHKKIHTEKK PYKCEECGKA
410 420 430 440 450
FKWSSKLTEH KLTHTGEKPY KCEECGKAFN WPSTLTKHNR IHTGEKPYKC
460 470 480 490 500
EVCGKAFNQF SNLTTHKRIH TAEKPYKCEE CGKAFSRSSN LTKHKKIHIE
510 520 530 540 550
KKPYKCEECG KAFKWSSKLT EHKITHTGEK PYKCEECGKA FNHFSILTKH
560 570 580 590 600
KRIHTGEKPY KCEECGKAFT QSSNLTTHKK IHTGEKFYKC EECGKAFTQS
610 620 630 640 650
SNLTTHKKIH TGGKPYKCEE CGKAFNQFST LTKHKIIHTE EKPYKCEECG
660 670 680 690 700
KAFKWSSTLT KHKIIHTGEK PYKCEECGKA FKLSSTLSTH KIIHTGEKPY
710 720 730 740 750
KCEKCGKAFN RSSNLIEHKK IHTGEQPYKC EECGKAFNYS SHLNTHKRIH
760 770 780 790 800
TKEQPYKCKE CGKAFNQYSN LTTHNKIHTG EKLYKPEDVT VILTTPQTFS

NIK
Length:803
Mass (Da):93,478
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A3BCB47ECDD1500
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471106 Genomic DNA Translation: EAW84909.1

NCBI Reference Sequences

More...
RefSeqi
NP_001243577.1, NM_001256648.1
NP_001243578.1, NM_001256649.1
NP_001243579.1, NM_001256650.1
XP_011526559.1, XM_011528257.2
XP_011526561.1, XM_011528259.2
XP_016882696.1, XM_017027207.1
XP_016882697.1, XM_017027208.1
XP_016882698.1, XM_017027209.1
XP_016882699.1, XM_017027210.1
XP_016882700.1, XM_017027211.1
XP_016882701.1, XM_017027212.1
XP_016882702.1, XM_017027213.1
XP_016882703.1, XM_017027214.1
XP_016882704.1, XM_017027215.1
XP_016882705.1, XM_017027216.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7594

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471106 Genomic DNA Translation: EAW84909.1
RefSeqiNP_001243577.1, NM_001256648.1
NP_001243578.1, NM_001256649.1
NP_001243579.1, NM_001256650.1
XP_011526559.1, XM_011528257.2
XP_011526561.1, XM_011528259.2
XP_016882696.1, XM_017027207.1
XP_016882697.1, XM_017027208.1
XP_016882698.1, XM_017027209.1
XP_016882699.1, XM_017027210.1
XP_016882700.1, XM_017027211.1
XP_016882701.1, XM_017027212.1
XP_016882702.1, XM_017027213.1
XP_016882703.1, XM_017027214.1
XP_016882704.1, XM_017027215.1
XP_016882705.1, XM_017027216.1

3D structure databases

SMRiA0A024R7P7
ModBaseiSearch...

Proteomic databases

PRIDEiA0A024R7P7

Genome annotation databases

GeneIDi7594

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7594

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
OrthoDBi1318335at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF43 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7594

Gene expression databases

BgeeiENSG00000198521 Expressed in 226 organ(s), highest expression level in lung
ExpressionAtlasiA0A024R7P7 baseline and differential

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 22 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 22 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R7P7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R7P7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: May 8, 2019
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again