UniProtKB - A0A024R7P2 (A0A024R7P2_HUMAN)
Protein
Peptidylprolyl isomerase
Gene
FKBP8
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:5.2.1.8PROSITE-ProRule annotation
GO - Molecular functioni
- peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Isomerase, RotamasePROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidylprolyl isomerasePROSITE-ProRule annotation (EC:5.2.1.8PROSITE-ProRule annotation) |
Gene namesi | Name:FKBP8Imported ORF Names:hCG_1776905Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000105701.15 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
Mitochondrion
- mitochondrion Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 388 – 410 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000105701, Expressed in anterior cingulate cortex and 224 other tissues |
ExpressionAtlasi | A0A024R7P2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 120 – 204 | PPIase FKBP-typeInterPro annotationAdd BLAST | 85 | |
Domaini | 272 – 339 | TPR_REGIONInterPro annotationAdd BLAST | 68 | |
Repeati | 272 – 305 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 306 – 339 | TPRPROSITE-ProRule annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 68 | DisorderedSequence analysisAdd BLAST | 68 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 25 – 53 | AcidicSequence analysisAdd BLAST | 29 |
Keywords - Domaini
TPR repeatPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_013615_1_3_1 |
OMAi | ECDILGN |
OrthoDBi | 787673at2759 |
PhylomeDBi | A0A024R7P2 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR001179, PPIase_FKBP_dom IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR013105, TPR_2 IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF00254, FKBP_C, 1 hit PF07719, TPR_2, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 3 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50059, FKBP_PPIASE, 1 hit PS50005, TPR, 2 hits PS50293, TPR_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R7P2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASCAEPSEP SAPLPAGVPP LEDFEVLDGV EDAEGEEEEE EEEEEEDDLS
60 70 80 90 100
ELPPLEDMGQ PPAEEAEQPG ALAREFLAAM EPEPAPAPAP EEWLDILGNG
110 120 130 140 150
LLRKKTLVPG PPGSSRPVKG QVVTVHLQTS LENGTRVQEE PELVFTLGDC
160 170 180 190 200
DVIQALDLSV PLMDVGETAM VTADSKYCYG PQGRSPYIPP HAALCLEVTL
210 220 230 240 250
KTAVDGPDLE MLTGQERVAL ANRKRECGNA HYQRADFVLA ANSYDLAIKA
260 270 280 290 300
ITSSAKVDMT FEEEAQLLQL KVKCLNNLAA SQLKLDHYRA ALRSCSLVLE
310 320 330 340 350
HQPDNIKALF RKGKVLAQQG EYSEAIPILR AALKLEPSNK TIHAELSKLV
360 370 380 390 400
KKHAAQRSTE TALYRKMLGN PSRLPAKCPG KGAWSIPWKW LFGATAVALG
410
GVALSVVIAA RN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471106 Genomic DNA Translation: EAW84710.1 |
RefSeqi | NP_001295302.1, NM_001308373.1 |
Genome annotation databases
GeneIDi | 23770 |
KEGGi | hsa:23770 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471106 Genomic DNA Translation: EAW84710.1 |
RefSeqi | NP_001295302.1, NM_001308373.1 |
3D structure databases
SMRi | A0A024R7P2 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 28073, 401 antibodies |
DNASUi | 23770 |
Genome annotation databases
GeneIDi | 23770 |
KEGGi | hsa:23770 |
Organism-specific databases
CTDi | 23770 |
VEuPathDBi | HostDB:ENSG00000105701.15 |
Phylogenomic databases
HOGENOMi | CLU_013615_1_3_1 |
OMAi | ECDILGN |
OrthoDBi | 787673at2759 |
PhylomeDBi | A0A024R7P2 |
Miscellaneous databases
BioGRID-ORCSi | 23770, 19 hits in 994 CRISPR screens |
ChiTaRSi | FKBP8, human |
GenomeRNAii | 23770 |
Gene expression databases
Bgeei | ENSG00000105701, Expressed in anterior cingulate cortex and 224 other tissues |
ExpressionAtlasi | A0A024R7P2, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR001179, PPIase_FKBP_dom IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR013105, TPR_2 IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF00254, FKBP_C, 1 hit PF07719, TPR_2, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 3 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50059, FKBP_PPIASE, 1 hit PS50005, TPR, 2 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R7P2_HUMAN | |
Accessioni | A0A024R7P2Primary (citable) accession number: A0A024R7P2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | April 7, 2021 | |
This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |