FKBP8

Functionⁱ

Catalytic activityⁱ

Peptidylproline (omega=180) = peptidylproline (omega=0).PROSITE-ProRule annotation

GO - Molecular functionⁱ

peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase, RotamasePROSITE-ProRule annotation

Molecular function

Isomerase, RotamasePROSITE-ProRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peptidylprolyl isomerasePROSITE-ProRule annotation (EC:5.2.1.8PROSITE-ProRule annotation)
Gene namesⁱ	Name:FKBP8Imported ORF Names:hCG_1776905Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105701.15

EuPathDBⁱ

HostDB:ENSG00000105701.15

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	388 – 410	HelicalSequence analysisAdd BLAST		23

Keywords - Cellular componentⁱ

Membrane

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000105701 Expressed in 211 organ(s), highest expression level in anterior cingulate cortex
ExpressionAtlasⁱ	A0A024R7P2 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A0A024R7P2
SMRⁱ	A0A024R7P2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	120 – 204	PPIase FKBP-typeInterPro annotationAdd BLAST	85
Domainⁱ	272 – 339	TPR_REGIONInterPro annotationAdd BLAST	68
Repeatⁱ	272 – 305	TPRPROSITE-ProRule annotationAdd BLAST	34
Repeatⁱ	306 – 339	TPRPROSITE-ProRule annotationAdd BLAST	34

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	27 – 47	Sequence analysisAdd BLAST		21

Keywords - Domainⁱ

Coiled coilSequence analysis, TPR repeatPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0543 Eukaryota COG0545 LUCA
KEGG Orthology (KO) More...KOⁱ	K09574
PhylomeDBⁱ	A0A024R7P2

Family and domain databases

Gene3Dⁱ	1.25.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR023566 PPIase_FKBP IPR001179 PPIase_FKBP_dom IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR013105 TPR_2 IPR019734 TPR_repeat
PANTHERⁱ	PTHR10516 PTHR10516, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00254 FKBP_C, 1 hit PF07719 TPR_2, 1 hit
SMARTⁱ	View protein in SMART SM00028 TPR, 3 hits
SUPFAMⁱ	SSF48452 SSF48452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50059 FKBP_PPIASE, 1 hit PS50005 TPR, 2 hits PS50293 TPR_REGION, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A024R7P2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASCAEPSEP SAPLPAGVPP LEDFEVLDGV EDAEGEEEEE EEEEEEDDLS 
        60         70         80         90        100
ELPPLEDMGQ PPAEEAEQPG ALAREFLAAM EPEPAPAPAP EEWLDILGNG 
       110        120        130        140        150
LLRKKTLVPG PPGSSRPVKG QVVTVHLQTS LENGTRVQEE PELVFTLGDC 
       160        170        180        190        200
DVIQALDLSV PLMDVGETAM VTADSKYCYG PQGRSPYIPP HAALCLEVTL 
       210        220        230        240        250
KTAVDGPDLE MLTGQERVAL ANRKRECGNA HYQRADFVLA ANSYDLAIKA 
       260        270        280        290        300
ITSSAKVDMT FEEEAQLLQL KVKCLNNLAA SQLKLDHYRA ALRSCSLVLE 
       310        320        330        340        350
HQPDNIKALF RKGKVLAQQG EYSEAIPILR AALKLEPSNK TIHAELSKLV 
       360        370        380        390        400
KKHAAQRSTE TALYRKMLGN PSRLPAKCPG KGAWSIPWKW LFGATAVALG 
       410 
GVALSVVIAA RN

Length:412

Mass (Da):44,562

Last modified:July 9, 2014 - v1

Checksum:ⁱ887C25ADE71EBA8D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471106 Genomic DNA Translation: EAW84710.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001295302.1, NM_001308373.1
UniGeneⁱ	Hs.173464

Genome annotation databases

GeneIDⁱ	23770
KEGGⁱ	hsa:23770

Protein	Similar proteins		Species	Score	Length	Source
A0A024R7P2	Peptidyl-prolyl cis-trans isomerase FKBP8	)	HUMAN		412	UniRef100_Q14318
UPI00020652F6		HUMAN		441

Protein	Similar proteins		Species	Score	Length	Source
A0A024R7P2	Peptidyl-prolyl cis-trans isomerase FKBP8	)	HUMAN		412	UniRef90_Q14318
Peptidyl-prolyl cis-trans isomerase FKBP8		RAT		403
Peptidylprolyl isomerase		PIG		484
Peptidylprolyl isomerase		CANLF		473
Peptidylprolyl isomerase		ODORO		471
+219

Protein	Similar proteins		Species	Score	Length	Source
A0A024R7P2	Peptidyl-prolyl cis-trans isomerase FKBP8	)	HUMAN		412	UniRef50_Q14318
Peptidyl-prolyl cis-trans isomerase FKBP8		RAT		403
Peptidyl-prolyl cis-trans isomerase FKBP8		MOUSE		402
Peptidylprolyl isomerase		PIG		484
Peptidylprolyl isomerase		CANLF		473
+478

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471106 Genomic DNA Translation: EAW84710.1
RefSeqⁱ	NP_001295302.1, NM_001308373.1
UniGeneⁱ	Hs.173464

3D structure databases

ProteinModelPortalⁱ	A0A024R7P2
SMRⁱ	A0A024R7P2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	23770
KEGGⁱ	hsa:23770

Organism-specific databases

CTDⁱ	23770
EuPathDBⁱ	HostDB:ENSG00000105701.15

Phylogenomic databases

eggNOGⁱ	KOG0543 Eukaryota COG0545 LUCA
KOⁱ	K09574
PhylomeDBⁱ	A0A024R7P2

Miscellaneous databases

ChiTaRSⁱ	FKBP8 human
GenomeRNAiⁱ	23770

Gene expression databases

Bgeeⁱ	ENSG00000105701 Expressed in 211 organ(s), highest expression level in anterior cingulate cortex
ExpressionAtlasⁱ	A0A024R7P2 baseline and differential

Family and domain databases

Gene3Dⁱ	1.25.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR023566 PPIase_FKBP IPR001179 PPIase_FKBP_dom IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR013105 TPR_2 IPR019734 TPR_repeat
PANTHERⁱ	PTHR10516 PTHR10516, 1 hit
Pfamⁱ	View protein in Pfam PF00254 FKBP_C, 1 hit PF07719 TPR_2, 1 hit
SMARTⁱ	View protein in SMART SM00028 TPR, 3 hits
SUPFAMⁱ	SSF48452 SSF48452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50059 FKBP_PPIASE, 1 hit PS50005 TPR, 2 hits PS50293 TPR_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A024R7P2_HUMAN
Accessionⁱ	A0A024R7P2Primary (citable) accession number: A0A024R7P2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 9, 2014
	Last sequence update:	July 9, 2014
	Last modified:	November 7, 2018
	This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A0A024R7P2 (A0A024R7P2_HUMAN)

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Peptidylprolyl isomerase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Endoplasmic reticulum

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ