UniProtKB - A0A024R7N8 (A0A024R7N8_HUMAN)
Protein
Submitted name:
Ceramide synthase 1
Gene
CERS1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Growth factorUniRule annotationSAAS annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Ceramide synthase 1ImportedSubmitted name: HCG2045882, isoform CRA_aImported |
Gene namesi | Name:CERS1Imported ORF Names:hCG_2045882Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14253 CERS1 |
Subcellular locationi
Extracellular region or secreted
- Secreted SAAS annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedSAAS annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_5014008784 | 30 – 372 | Sequence analysisAdd BLAST | 343 |
Keywords - PTMi
Disulfide bondSAAS annotationProteomic databases
PRIDEi | A0A024R7N8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000223802 Expressed in 126 organ(s), highest expression level in medial globus pallidus |
ExpressionAtlasi | A0A024R7N8 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 250 – 372 | TGF_BETA_2InterPro annotationAdd BLAST | 123 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 67 – 86 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3900 Eukaryota ENOG410XT8Z LUCA |
KOi | K05495 |
OMAi | HYQDMVV |
OrthoDBi | 1106226at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034 Cystine-knot_cytokine IPR001839 TGF-b_C IPR015615 TGF-beta-rel IPR017948 TGFb_CS |
PANTHERi | PTHR11848 PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019 TGF_beta, 1 hit |
SMARTi | View protein in SMART SM00204 TGFB, 1 hit |
SUPFAMi | SSF57501 SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250 TGF_BETA_1, 1 hit PS51362 TGF_BETA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A0A024R7N8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPPQQGPCG HHLLLLLALL LPSLPLTRAP VPPGPAAALL QALGLRDEPQ
60 70 80 90 100
GAPRLRPVPP VMWRLFRRRD PQETRSGSRR TSPGVTLQPC HVEELGVAGN
110 120 130 140 150
IVRHIPDRGA PTRASEPASA AGHCPEWTVV FDLSAVEPAE RPSRARLELR
160 170 180 190 200
FAAAAAAAPE GGWELSVAQA GQGAGADPGP VLLRQLVPAL GPPVRAELLG
210 220 230 240 250
AAWARNASWP RSLRLALALR PRAPAACARL AEASLLLVTL DPRLCHPLAR
260 270 280 290 300
PRRDAEPVLG GGPGGACRAR RLYVSFREVG WHRWVIAPRG FLANYCQGQC
310 320 330 340 350
ALPVALSGSG GPPALNHAVL RALMHAAAPG AADLPCCVPA RLSPISVLFF
360 370
DNSDNVVLRQ YEDMVVDECG CR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP27544 | CERS1_HUMAN | Ceramide synthase 1 | CERS1 LAG1, LASS1, UOG1 | 350 | Annotation score: | ||
Q5XG75 | Q5XG75_HUMAN | Ceramide synthase 1 | CERS1 LASS1 | 239 | Annotation score: | ||
M0R0T2 | M0R0T2_HUMAN | Ceramide synthase 1 | CERS1 | 216 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC003972 Genomic DNA No translation available. AC005197 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84743.1 CH471106 Genomic DNA Translation: EAW84744.1 |
RefSeqi | NP_001483.3, NM_001492.5 |
Genome annotation databases
Ensembli | ENST00000623927; ENSP00000485582; ENSG00000223802 |
GeneIDi | 2657 |
KEGGi | hsa:2657 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC003972 Genomic DNA No translation available. AC005197 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84743.1 CH471106 Genomic DNA Translation: EAW84744.1 |
RefSeqi | NP_001483.3, NM_001492.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | A0A024R7N8 |
Genome annotation databases
Ensembli | ENST00000623927; ENSP00000485582; ENSG00000223802 |
GeneIDi | 2657 |
KEGGi | hsa:2657 |
Organism-specific databases
CTDi | 2657 |
HGNCi | HGNC:14253 CERS1 |
OpenTargetsi | ENSG00000223802 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3900 Eukaryota ENOG410XT8Z LUCA |
KOi | K05495 |
OMAi | HYQDMVV |
OrthoDBi | 1106226at2759 |
Miscellaneous databases
ChiTaRSi | CERS1 human |
GenomeRNAii | 2657 |
Gene expression databases
Bgeei | ENSG00000223802 Expressed in 126 organ(s), highest expression level in medial globus pallidus |
ExpressionAtlasi | A0A024R7N8 baseline and differential |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034 Cystine-knot_cytokine IPR001839 TGF-b_C IPR015615 TGF-beta-rel IPR017948 TGFb_CS |
PANTHERi | PTHR11848 PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019 TGF_beta, 1 hit |
SMARTi | View protein in SMART SM00204 TGFB, 1 hit |
SUPFAMi | SSF57501 SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250 TGF_BETA_1, 1 hit PS51362 TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R7N8_HUMAN | |
Accessioni | A0A024R7N8Primary (citable) accession number: A0A024R7N8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | October 16, 2019 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |