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Protein
Submitted name:

UPF1 regulator of nonsense transcripts homolog (Yeast), isoform CRA_a

Gene

UPF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
UPF1 regulator of nonsense transcripts homolog (Yeast), isoform CRA_aImported
Gene namesi
Name:UPF1Imported
ORF Names:hCG_37042Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000005007.12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSG00000005007 Expressed in 210 organ(s), highest expression level in cerebellar hemisphere

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 272UPF1-typeInterPro annotationAdd BLAST152
Domaini496 – 550ResIIIInterPro annotationAdd BLAST55

Phylogenomic databases

eggNOGiKOG1802 Eukaryota
COG1112 LUCA
KOiK14326
OMAiQPCAAQN
OrthoDBiEOG091G01B6

Family and domain databases

InterProiView protein in InterPro
IPR006935 Helicase/UvrB_N
IPR027417 P-loop_NTPase
IPR018999 RNA-helicase_UPF1_UPF2-interct
PfamiView protein in Pfam
PF04851 ResIII, 1 hit
PF09416 UPF1_Zn_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

A0A024R7L8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTPPGG
60 70 80 90 100
PGGPGGGGAG GPGGAGAGAA AGQLDAQVGP EGILQNGAVD DSVAKTSQLL
110 120 130 140 150
AELNFEEDEE DTYYTKDLPI HACSYCGIHD PACVVYCNTS KKWFCNGRGN
160 170 180 190 200
TSGSHIVNHL VRAKCKEVTL HKDGPLGETV LECYNCGCRN VFLLGFIPAK
210 220 230 240 250
ADSVVVLLCR QPCASQSSLK DINWDSSQWQ PLIQDRCFLS WLVKIPSEQE
260 270 280 290 300
QLRARQITAQ QINKLEELWK ENPSATLEDL EKPGVDEEPQ HVLLRYEDAY
310 320 330 340 350
QYQNIFGPLV KLEADYDKKL KESQTQDNIT VRWDLGLNKK RIAYFTLPKT
360 370 380 390 400
DSGNEDLVII WLRDMRLMQG DEICLRYKGD LAPLWKGIGH VIKVPDNYGD
410 420 430 440 450
EIAIELRSSV GAPVEVTHNF QVDFVWKSTS FDRMQSALKT FAVDETSVSG
460 470 480 490 500
YIYHKLLGHE VEDVIIKCQL PKRFTAQGLP DLNHSQVYAV KTVLQRPLSL
510 520 530 540 550
IQGPPGTGKT VTSATIVYHL ARQGNGPVLV CAPSNIAVDQ LTEKIHQTGL
560 570 580 590 600
KVVRLCAKSR EAIDSPVSFL ALHNQIRNMD SMPELQKLQQ LKDETGELSS
610 620 630 640 650
ADEKRYRALK RTAERELLMN ADVICCTCVG AGDPRLAKMQ FRSILIDEST
660 670 680 690 700
QATEPECMVP VVLGAKQLIL VGDHCQLGPV VMCKKAAKAG LSQSLFERLV
710 720 730 740 750
VLGIRPIRLQ VQYRMHPALS AFPSNIFYEG SLQNGVTAAD RVKKGFDFQW
760 770 780 790 800
PQPDKPMFFY VTQGQEEIAS SGTSYLNRTE AANVEKITTK LLKAGAKPDQ
810 820 830 840 850
IGIITPYEGQ RSYLVQYMQF SGSLHTKLYQ EVEIASVDAF QGREKDFIIL
860 870 880 890 900
SCVRANEHQG IGFLNDPRRL NVALTRARYG VIIVGNPKAL SKQPLWNHLL
910 920 930 940 950
NYYKEQKVLV EGPLNNLRES LMQFSKPRKL VNTINPGARF MTTAMYDARE
960 970 980 990 1000
AIIPGSVYDR SSQGRPSSMY FQTHDQIGMI SAGPSHVAAM NIPIPFNLVM
1010 1020 1030 1040 1050
PPMPPPGYFG QANGPAAGRG TPKGKTGRGG RQKNRFGLPG PSQTNLPNSQ
1060 1070 1080 1090 1100
ASQDVASQPF SQGALTQGYI SMSQPSQMSQ PGLSQPELSQ DSYLGDEFKS
1110 1120
QIDVALSQDS TYQGERAYQH GGVTGLSQY
Length:1,129
Mass (Da):124,345
Last modified:July 9, 2014 - v1
Checksum:i6CCA6FE42B15BA28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471106 Genomic DNA Translation: EAW84738.1
CH471106 Genomic DNA Translation: EAW84741.1
RefSeqiNP_001284478.1, NM_001297549.1
UniGeneiHs.515266

Genome annotation databases

GeneIDi5976
KEGGihsa:5976

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471106 Genomic DNA Translation: EAW84738.1
CH471106 Genomic DNA Translation: EAW84741.1
RefSeqiNP_001284478.1, NM_001297549.1
UniGeneiHs.515266

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5976
KEGGihsa:5976

Organism-specific databases

CTDi5976
EuPathDBiHostDB:ENSG00000005007.12

Phylogenomic databases

eggNOGiKOG1802 Eukaryota
COG1112 LUCA
KOiK14326
OMAiQPCAAQN
OrthoDBiEOG091G01B6

Miscellaneous databases

ChiTaRSiUPF1 human
GenomeRNAii5976

Gene expression databases

BgeeiENSG00000005007 Expressed in 210 organ(s), highest expression level in cerebellar hemisphere

Family and domain databases

InterProiView protein in InterPro
IPR006935 Helicase/UvrB_N
IPR027417 P-loop_NTPase
IPR018999 RNA-helicase_UPF1_UPF2-interct
PfamiView protein in Pfam
PF04851 ResIII, 1 hit
PF09416 UPF1_Zn_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R7L8_HUMAN
AccessioniPrimary (citable) accession number: A0A024R7L8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 10, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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