UniProtKB - A0A024R7K5 (A0A024R7K5_HUMAN)
Protein
Submitted name:
MADS box transcription enhancer factor 2, polypeptide B (Myocyte enhancer factor 2B), isoform CRA_a
Gene
MEF2B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: InterPro
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: MADS box transcription enhancer factor 2, polypeptide B (Myocyte enhancer factor 2B), isoform CRA_aImported |
Gene namesi | Name:MEF2BImported ORF Names:hCG_38559Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000213999.15 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- cell junction Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000213999, Expressed in muscle tissue and 112 other tissues |
ExpressionAtlasi | A0A024R7K5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 61 | MADS-boxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 124 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 142 – 368 | DisorderedSequence analysisAdd BLAST | 227 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 223 – 241 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 245 – 274 | Pro-richSequence analysisAdd BLAST | 30 |
Phylogenomic databases
OrthoDBi | 729387at2759 |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R7K5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRKKIQISR ILDQRNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS
60 70 80 90 100
ANRLFQYAST DMDRVLLKYT EYSEPHESRT NTDILETLKR RGIGLDGPEL
110 120 130 140 150
EPDEGPEEPG EKFRRLAGEG GDPALPRPRL YPAAPAMPSP DVVYGALPPP
160 170 180 190 200
GCDPSGLGEA LPAQSRPSPF RPAAPKAGPP GLVHPLFSPS HLTSKTPPPL
210 220 230 240 250
YLPTEGRRSD LPGGLAGPRG GLNTSRSLYS GLQNPCSTAT PGPPLGSFPF
260 270 280 290 300
LPGGPPEYGL GDPPPPPGLL QPPTLAPWQP SRGDGPPAVS SQPSGGRSLG
310 320 330 340 350
EEGPPTRGAS PPTPPVSIKS ERLSPAPGGP GDFPKTFPYP LLLARSLAEP
360
LRPGPALRRL PLADGWPR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471106 Genomic DNA Translation: EAW84793.1 |
RefSeqi | NP_001139257.1, NM_001145785.1 |
Genome annotation databases
GeneIDi | 100271849 |
KEGGi | hsa:100271849 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471106 Genomic DNA Translation: EAW84793.1 |
RefSeqi | NP_001139257.1, NM_001145785.1 |
3D structure databases
SMRi | A0A024R7K5 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 47983, 150 antibodies |
Genome annotation databases
GeneIDi | 100271849 |
KEGGi | hsa:100271849 |
Organism-specific databases
CTDi | 100271849 |
EuPathDBi | HostDB:ENSG00000213999.15 |
Phylogenomic databases
OrthoDBi | 729387at2759 |
Miscellaneous databases
BioGRID-ORCSi | 100271849, 13 hits in 481 CRISPR screens |
GenomeRNAii | 100271849 |
Gene expression databases
Bgeei | ENSG00000213999, Expressed in muscle tissue and 112 other tissues |
ExpressionAtlasi | A0A024R7K5, baseline and differential |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R7K5_HUMAN | |
Accessioni | A0A024R7K5Primary (citable) accession number: A0A024R7K5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 43 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |