UniProtKB - A0A024R7G6 (A0A024R7G6_HUMAN)
Protein
Submitted name:
Epidermal growth factor receptor pathway substrate 15-like 1, isoform CRA_a
Gene
EPS15L1
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 172 – 183 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
Keywordsi
Molecular function | ReceptorImported |
Ligand | CalciumPROSITE-ProRule annotation, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Epidermal growth factor receptor pathway substrate 15-like 1, isoform CRA_aImported |
Gene namesi | Name:EPS15L1Imported ORF Names:hCG_36964Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000127527.13 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127527, Expressed in gastrocnemius and 208 other tissues |
ExpressionAtlasi | A0A024R7G6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 104 | EHInterPro annotationAdd BLAST | 90 | |
Domaini | 48 – 83 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 127 – 215 | EHInterPro annotationAdd BLAST | 89 | |
Domaini | 159 – 194 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 274 – 309 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 275 – 365 | EHInterPro annotationAdd BLAST | 91 | |
Domaini | 310 – 343 | EF-handInterPro annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 221 – 261 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 349 – 381 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 614 – 732 | DisorderedSequence analysisAdd BLAST | 119 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 386 – 469 | Sequence analysisAdd BLAST | 84 | |
Coiled coili | 477 – 553 | Sequence analysisAdd BLAST | 77 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 235 – 261 | PolarSequence analysisAdd BLAST | 27 | |
Compositional biasi | 620 – 634 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 645 – 659 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 668 – 683 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 684 – 722 | PolarSequence analysisAdd BLAST | 39 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
OrthoDBi | 597979at2759 |
Family and domain databases
CDDi | cd00052, EH, 3 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000261, EH_dom |
Pfami | View protein in Pfam PF12763, EF-hand_4, 3 hits |
SMARTi | View protein in SMART SM00054, EFh, 3 hits SM00027, EH, 3 hits |
SUPFAMi | SSF47473, SSF47473, 3 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 4 hits PS50031, EH, 3 hits |
i Sequence
Sequence statusi: Complete.
A0A024R7G6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPLIPLSQ QIPTGNSLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD
60 70 80 90 100
IILGKIWDLA DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSNLNLSMPP
110 120 130 140 150
PKFHDTSSPL MVTPPSAEAH WAVRVEEKAK FDGIFESLLP INGLLSGDKV
160 170 180 190 200
KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD RDEFAVAMHL VYRALEKEPV
210 220 230 240 250
PSALPPSLIP PSKRKKTVFP GAVPVLPASP PPKDSLRSTP SHGSVSSLNS
260 270 280 290 300
TGSLSPKHSL KQTQPTVNWV VPVADKMRFD EIFLKTDLDL DGYVSGQEVK
310 320 330 340 350
EIFMHSGLTQ NLLAHIWALA DTRQTGKLSK DQFALAMYFI QQKVSKGIDP
360 370 380 390 400
PQVLSPDMVP PSERGTPGPD SSGSLGSGEF TGVKELDDIS QEIAQLQREK
410 420 430 440 450
YSLEQDIREK EEAIRQKTSE VQELQNDLDR ETSSLQELEA QKQDAQDRLD
460 470 480 490 500
EMDQQKAKLR DMLSDVRQKC QDETQMISSL KTQIQSQESD LKSQEDDLNR
510 520 530 540 550
AKSELNRLQQ EETQLEQSIQ AGRVQLETII KSLKSTQDEI NQARSKLSQL
560 570 580 590 600
HESRQEAHRS LEQYDQVLDG AHGASLTDLA NLSEGVSLAE RGSFGAMDDP
610 620 630 640 650
FKNKALLFSN NTQELHPDPF QTEDPFKSDP FKGADPFKGD PFQNDPFAEQ
660 670 680 690 700
QTTSTDPFGG DPFKESDPFR GSATDDFFKK QTKNDPFTSD PFTKNPSLPS
710 720 730 740 750
KLDPFESSDP FSSSSVSSKG SDPFGTLDPF GSGSFNSAEG FADFSQMSKV
KVHL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471106 Genomic DNA Translation: EAW84543.1 |
RefSeqi | NP_001245304.1, NM_001258375.1 |
Genome annotation databases
GeneIDi | 58513 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471106 Genomic DNA Translation: EAW84543.1 |
RefSeqi | NP_001245304.1, NM_001258375.1 |
3D structure databases
SMRi | A0A024R7G6 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 14142, 193 antibodies |
Genome annotation databases
GeneIDi | 58513 |
Organism-specific databases
CTDi | 58513 |
EuPathDBi | HostDB:ENSG00000127527.13 |
Phylogenomic databases
OrthoDBi | 597979at2759 |
Miscellaneous databases
BioGRID-ORCSi | 58513, 22 hits in 849 CRISPR screens |
ChiTaRSi | EPS15L1, human |
GenomeRNAii | 58513 |
Gene expression databases
Bgeei | ENSG00000127527, Expressed in gastrocnemius and 208 other tissues |
ExpressionAtlasi | A0A024R7G6, baseline and differential |
Family and domain databases
CDDi | cd00052, EH, 3 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000261, EH_dom |
Pfami | View protein in Pfam PF12763, EF-hand_4, 3 hits |
SMARTi | View protein in SMART SM00054, EFh, 3 hits SM00027, EH, 3 hits |
SUPFAMi | SSF47473, SSF47473, 3 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 4 hits PS50031, EH, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R7G6_HUMAN | |
Accessioni | A0A024R7G6Primary (citable) accession number: A0A024R7G6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |