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Protein
Submitted name:

Epidermal growth factor receptor pathway substrate 15-like 1, isoform CRA_a

Gene

EPS15L1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi172 – 183PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionReceptorImported
LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Epidermal growth factor receptor pathway substrate 15-like 1, isoform CRA_aImported
Gene namesi
Name:EPS15L1Imported
ORF Names:hCG_36964Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000127527.13

PTM / Processingi

Proteomic databases

PRIDEiA0A024R7G6

Expressioni

Gene expression databases

BgeeiENSG00000127527 Expressed in 196 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiA0A024R7G6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A024R7G6
SMRiA0A024R7G6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 104EHInterPro annotationAdd BLAST90
Domaini48 – 83EF-handInterPro annotationAdd BLAST36
Domaini127 – 215EHInterPro annotationAdd BLAST89
Domaini159 – 194EF-handInterPro annotationAdd BLAST36
Domaini274 – 309EF-handInterPro annotationAdd BLAST36
Domaini275 – 365EHInterPro annotationAdd BLAST91
Domaini310 – 343EF-handInterPro annotationAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili386 – 469Sequence analysisAdd BLAST84
Coiled coili477 – 553Sequence analysisAdd BLAST77

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0998 Eukaryota
ENOG410XTDR LUCA

Family and domain databases

CDDicd00052 EH, 3 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
PfamiView protein in Pfam
PF12763 EF-hand_4, 3 hits
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SM00027 EH, 3 hits
SUPFAMiSSF47473 SSF47473, 3 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 4 hits
PS50031 EH, 3 hits

Sequencei

Sequence statusi: Complete.

A0A024R7G6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPLIPLSQ QIPTGNSLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD
60 70 80 90 100
IILGKIWDLA DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSNLNLSMPP
110 120 130 140 150
PKFHDTSSPL MVTPPSAEAH WAVRVEEKAK FDGIFESLLP INGLLSGDKV
160 170 180 190 200
KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD RDEFAVAMHL VYRALEKEPV
210 220 230 240 250
PSALPPSLIP PSKRKKTVFP GAVPVLPASP PPKDSLRSTP SHGSVSSLNS
260 270 280 290 300
TGSLSPKHSL KQTQPTVNWV VPVADKMRFD EIFLKTDLDL DGYVSGQEVK
310 320 330 340 350
EIFMHSGLTQ NLLAHIWALA DTRQTGKLSK DQFALAMYFI QQKVSKGIDP
360 370 380 390 400
PQVLSPDMVP PSERGTPGPD SSGSLGSGEF TGVKELDDIS QEIAQLQREK
410 420 430 440 450
YSLEQDIREK EEAIRQKTSE VQELQNDLDR ETSSLQELEA QKQDAQDRLD
460 470 480 490 500
EMDQQKAKLR DMLSDVRQKC QDETQMISSL KTQIQSQESD LKSQEDDLNR
510 520 530 540 550
AKSELNRLQQ EETQLEQSIQ AGRVQLETII KSLKSTQDEI NQARSKLSQL
560 570 580 590 600
HESRQEAHRS LEQYDQVLDG AHGASLTDLA NLSEGVSLAE RGSFGAMDDP
610 620 630 640 650
FKNKALLFSN NTQELHPDPF QTEDPFKSDP FKGADPFKGD PFQNDPFAEQ
660 670 680 690 700
QTTSTDPFGG DPFKESDPFR GSATDDFFKK QTKNDPFTSD PFTKNPSLPS
710 720 730 740 750
KLDPFESSDP FSSSSVSSKG SDPFGTLDPF GSGSFNSAEG FADFSQMSKV

KVHL
Length:754
Mass (Da):83,248
Last modified:July 9, 2014 - v1
Checksum:i5FFC0740FA78FC8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471106 Genomic DNA Translation: EAW84543.1
RefSeqiNP_001245304.1, NM_001258375.1
UniGeneiHs.654639
Hs.683428
Hs.744842

Genome annotation databases

GeneIDi58513

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471106 Genomic DNA Translation: EAW84543.1
RefSeqiNP_001245304.1, NM_001258375.1
UniGeneiHs.654639
Hs.683428
Hs.744842

3D structure databases

ProteinModelPortaliA0A024R7G6
SMRiA0A024R7G6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA0A024R7G6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58513

Organism-specific databases

CTDi58513
EuPathDBiHostDB:ENSG00000127527.13

Phylogenomic databases

eggNOGiKOG0998 Eukaryota
ENOG410XTDR LUCA

Miscellaneous databases

ChiTaRSiEPS15L1 human
GenomeRNAii58513

Gene expression databases

BgeeiENSG00000127527 Expressed in 196 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiA0A024R7G6 baseline and differential

Family and domain databases

CDDicd00052 EH, 3 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
PfamiView protein in Pfam
PF12763 EF-hand_4, 3 hits
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SM00027 EH, 3 hits
SUPFAMiSSF47473 SSF47473, 3 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 4 hits
PS50031 EH, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R7G6_HUMAN
AccessioniPrimary (citable) accession number: A0A024R7G6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 12, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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