EPS15L1

Functionⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	172 – 183	PROSITE-ProRule annotationAdd BLAST		12

GO - Molecular functionⁱ

calcium ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	ReceptorImported
Ligand	CalciumPROSITE-ProRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Epidermal growth factor receptor pathway substrate 15-like 1, isoform CRA_aImported
Gene namesⁱ	Name:EPS15L1Imported ORF Names:hCG_36964Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000127527.13

EuPathDBⁱ

HostDB:ENSG00000127527.13

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	A0A024R7G6

PRIDEⁱ

A0A024R7G6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000127527 Expressed in 196 organ(s), highest expression level in gastrocnemius
ExpressionAtlasⁱ	A0A024R7G6 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A0A024R7G6
SMRⁱ	A0A024R7G6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	15 – 104	EHInterPro annotationAdd BLAST	90
Domainⁱ	48 – 83	EF-handInterPro annotationAdd BLAST	36
Domainⁱ	127 – 215	EHInterPro annotationAdd BLAST	89
Domainⁱ	159 – 194	EF-handInterPro annotationAdd BLAST	36
Domainⁱ	274 – 309	EF-handInterPro annotationAdd BLAST	36
Domainⁱ	275 – 365	EHInterPro annotationAdd BLAST	91
Domainⁱ	310 – 343	EF-handInterPro annotationAdd BLAST	34

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	386 – 469	Sequence analysisAdd BLAST		84
Coiled coilⁱ	477 – 553	Sequence analysisAdd BLAST		77

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0998 Eukaryota ENOG410XTDR LUCA

eggNOGⁱ

KOG0998 Eukaryota
ENOG410XTDR LUCA

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00052 EH, 3 hits
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR000261 EH_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12763 EF-hand_4, 3 hits
SMARTⁱ	View protein in SMART SM00054 EFh, 3 hits SM00027 EH, 3 hits
SUPFAMⁱ	SSF47473 SSF47473, 3 hits
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 4 hits PS50031 EH, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A024R7G6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAPLIPLSQ QIPTGNSLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD 
        60         70         80         90        100
IILGKIWDLA DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSNLNLSMPP 
       110        120        130        140        150
PKFHDTSSPL MVTPPSAEAH WAVRVEEKAK FDGIFESLLP INGLLSGDKV 
       160        170        180        190        200
KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD RDEFAVAMHL VYRALEKEPV 
       210        220        230        240        250
PSALPPSLIP PSKRKKTVFP GAVPVLPASP PPKDSLRSTP SHGSVSSLNS 
       260        270        280        290        300
TGSLSPKHSL KQTQPTVNWV VPVADKMRFD EIFLKTDLDL DGYVSGQEVK 
       310        320        330        340        350
EIFMHSGLTQ NLLAHIWALA DTRQTGKLSK DQFALAMYFI QQKVSKGIDP 
       360        370        380        390        400
PQVLSPDMVP PSERGTPGPD SSGSLGSGEF TGVKELDDIS QEIAQLQREK 
       410        420        430        440        450
YSLEQDIREK EEAIRQKTSE VQELQNDLDR ETSSLQELEA QKQDAQDRLD 
       460        470        480        490        500
EMDQQKAKLR DMLSDVRQKC QDETQMISSL KTQIQSQESD LKSQEDDLNR 
       510        520        530        540        550
AKSELNRLQQ EETQLEQSIQ AGRVQLETII KSLKSTQDEI NQARSKLSQL 
       560        570        580        590        600
HESRQEAHRS LEQYDQVLDG AHGASLTDLA NLSEGVSLAE RGSFGAMDDP 
       610        620        630        640        650
FKNKALLFSN NTQELHPDPF QTEDPFKSDP FKGADPFKGD PFQNDPFAEQ 
       660        670        680        690        700
QTTSTDPFGG DPFKESDPFR GSATDDFFKK QTKNDPFTSD PFTKNPSLPS 
       710        720        730        740        750
KLDPFESSDP FSSSSVSSKG SDPFGTLDPF GSGSFNSAEG FADFSQMSKV 

KVHL

Length:754

Mass (Da):83,248

Last modified:July 9, 2014 - v1

Checksum:ⁱ5FFC0740FA78FC8B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471106 Genomic DNA Translation: EAW84543.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001245304.1, NM_001258375.1
UniGeneⁱ	Hs.654639 Hs.683428 Hs.744842

Genome annotation databases

GeneIDⁱ	58513

GeneIDⁱ

58513

Protein	Similar proteins		Species	Score	Length	Source
A0A024R7G6	Isoform 3 of Epidermal growth factor receptor substrate 15-like 1		HUMAN		754	UniRef100_A0A024R7G6
Uncharacterized protein DKFZp586A0524 (Fragment)		HUMAN		185

Protein	Similar proteins		Species	Score	Length	Source
A0A024R7G6	Uncharacterized protein		MACMU		754	UniRef90_A0A1D5QFR2
Uncharacterized protein		PROCO		771
Uncharacterized protein		Cebus capucinus imitator		762
epidermal growth factor receptor substrate 15-like 1 isoform X4		Enhydra lutris kenyoni		761
Uncharacterized protein		RHIRO		754
+45

Protein	Similar proteins		Species	Score	Length	Source
A0A024R7G6	Epidermal growth factor receptor substrate 15-like 1		HUMAN		864	UniRef50_Q9UBC2
Epidermal growth factor receptor substrate 15-like 1		MOUSE		907
epidermal growth factor receptor substrate 15-like 1 isoform X1		DELLE		947
Uncharacterized protein		AOTNA		947
Uncharacterized protein		ICTTR		935
+713

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471106 Genomic DNA Translation: EAW84543.1
RefSeqⁱ	NP_001245304.1, NM_001258375.1
UniGeneⁱ	Hs.654639 Hs.683428 Hs.744842

3D structure databases

ProteinModelPortalⁱ	A0A024R7G6
SMRⁱ	A0A024R7G6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	A0A024R7G6

PRIDEⁱ

A0A024R7G6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	58513

GeneIDⁱ

58513

Organism-specific databases

CTDⁱ	58513
EuPathDBⁱ	HostDB:ENSG00000127527.13

Phylogenomic databases

eggNOGⁱ	KOG0998 Eukaryota ENOG410XTDR LUCA

eggNOGⁱ

KOG0998 Eukaryota
ENOG410XTDR LUCA

Miscellaneous databases

ChiTaRSⁱ	EPS15L1 human
GenomeRNAiⁱ	58513

Gene expression databases

Bgeeⁱ	ENSG00000127527 Expressed in 196 organ(s), highest expression level in gastrocnemius
ExpressionAtlasⁱ	A0A024R7G6 baseline and differential

Family and domain databases

CDDⁱ	cd00052 EH, 3 hits
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR000261 EH_dom
Pfamⁱ	View protein in Pfam PF12763 EF-hand_4, 3 hits
SMARTⁱ	View protein in SMART SM00054 EFh, 3 hits SM00027 EH, 3 hits
SUPFAMⁱ	SSF47473 SSF47473, 3 hits
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 4 hits PS50031 EH, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A024R7G6_HUMAN
Accessionⁱ	A0A024R7G6Primary (citable) accession number: A0A024R7G6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 9, 2014
	Last sequence update:	July 9, 2014
	Last modified:	September 12, 2018
	This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A0A024R7G6 (A0A024R7G6_HUMAN)

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Epidermal growth factor receptor pathway substrate 15-like 1, isoform CRA_a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ