We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - A0A024R7C1 (A0A024R7C1_HUMAN)
Protein
Submitted name:
HCG2033729, isoform CRA_a
Gene
hCG_2033729
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- cell-cell adhesion Source: InterPro
Keywordsi
Biological process | Cell adhesionARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: HCG2033729, isoform CRA_aImported |
Gene namesi | ORF Names:hCG_2033729Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000076662 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProt
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 486 – 510 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_5001533224 | 30 – 547 | Sequence analysisAdd BLAST | 518 |
Expressioni
Gene expression databases
Bgeei | ENSG00000076662, Expressed in blood and 197 other tissues |
ExpressionAtlasi | A0A024R7C1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 117 – 193 | Ig-likeInterPro annotationAdd BLAST | 77 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OMAi | IDRAKCP |
OrthoDBi | 731140at2759 |
PhylomeDBi | A0A024R7C1 |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR003988, ICAM IPR013768, ICAM_N IPR003987, ICAM_VCAM_N IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
Pfami | View protein in Pfam PF03921, ICAM_N, 1 hit |
PRINTSi | PR01473, ICAM PR01472, ICAMVCAM1 |
SMARTi | View protein in SMART SM00409, IG, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R7C1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATMVPSVLW PRACWTLLVC CLLTPGVQGQ EFLLRVEPQN PVLSAGGSLF
60 70 80 90 100
VNCSTDCPSS EKIALETSLS KELVASGMGW AAFNLSNVTG NSRILCSVYC
110 120 130 140 150
NGSQITGSSN ITVYRLPERV ELAPLPPWQP VGQNFTLRCQ VEDGSPRTSL
160 170 180 190 200
TVVLLRWEEE LSRQPAVEEP AEVTATVLAS RDDHGAPFSC RTELDMQPQG
210 220 230 240 250
LGLFVNTSAP RQLRTFVLPV TPPRLVAPRF LEVETSWPVD CTLDGLFPAS
260 270 280 290 300
EAQVYLALGD QMLNATVMNH GDTLTATATA TARADQEGAR EIVCNVTLGG
310 320 330 340 350
ERREARENLT VFSFLGPIVN LSEPTAHEGS TVTVSCMAGA RVQVTLDGVP
360 370 380 390 400
AAAPGQPAQL QLNATESDDG RSFFCSATLE VDGEFLHRNS SVQLRVLYGP
410 420 430 440 450
KIDRATCPQH LKWKDKTRHV LQCQARGNPY PELRCLKEGS SREVPVGIPF
460 470 480 490 500
FVNVTHNGTY QCQASSSRGK YTLVVVMDIE AGSSHFVPVF VAVLLTLGVV
510 520 530 540
TIVLALMYVF REHQRSGSYH VREESTYLPL TSMQPTEAMG EEPSRAE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471106 Genomic DNA Translation: EAW84096.1 |
RefSeqi | NP_002153.2, NM_002162.4 |
Genome annotation databases
GeneIDi | 3385 |
KEGGi | hsa:3385 |
MANE-Selecti | ENST00000160262.10; ENSP00000160262.3; NM_002162.5; NP_002153.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471106 Genomic DNA Translation: EAW84096.1 |
RefSeqi | NP_002153.2, NM_002162.4 |
3D structure databases
SMRi | A0A024R7C1 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 3738, 1546 antibodies from 45 providers |
DNASUi | 3385 |
Genome annotation databases
GeneIDi | 3385 |
KEGGi | hsa:3385 |
MANE-Selecti | ENST00000160262.10; ENSP00000160262.3; NM_002162.5; NP_002153.2 |
Organism-specific databases
CTDi | 3385 |
VEuPathDBi | HostDB:ENSG00000076662 |
Phylogenomic databases
OMAi | IDRAKCP |
OrthoDBi | 731140at2759 |
PhylomeDBi | A0A024R7C1 |
Miscellaneous databases
BioGRID-ORCSi | 3385, 15 hits in 1078 CRISPR screens |
GenomeRNAii | 3385 |
Gene expression databases
Bgeei | ENSG00000076662, Expressed in blood and 197 other tissues |
ExpressionAtlasi | A0A024R7C1, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR003988, ICAM IPR013768, ICAM_N IPR003987, ICAM_VCAM_N IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
Pfami | View protein in Pfam PF03921, ICAM_N, 1 hit |
PRINTSi | PR01473, ICAM PR01472, ICAMVCAM1 |
SMARTi | View protein in SMART SM00409, IG, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R7C1_HUMAN | |
Accessioni | A0A024R7C1Primary (citable) accession number: A0A024R7C1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | May 25, 2022 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |