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Entry version 24 (07 Oct 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Choline transporter-like protein 2 isoform 2

Gene

SLC44A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Choline transporter-like protein 2 isoform 2Imported
Submitted name:
Solute carrier family 44, member 2, isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC44A2Imported
ORF Names:hCG_28494Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 53HelicalSequence analysisAdd BLAST22
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Transmembranei257 – 275HelicalSequence analysisAdd BLAST19
Transmembranei313 – 334HelicalSequence analysisAdd BLAST22
Transmembranei354 – 377HelicalSequence analysisAdd BLAST24
Transmembranei450 – 477HelicalSequence analysisAdd BLAST28
Transmembranei498 – 520HelicalSequence analysisAdd BLAST23
Transmembranei560 – 583HelicalSequence analysisAdd BLAST24
Transmembranei595 – 619HelicalSequence analysisAdd BLAST25
Transmembranei635 – 655HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A024R798

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CTL (choline transporter-like) family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007603, Choline_transptr-like

The PANTHER Classification System

More...
PANTHERi
PTHR12385, PTHR12385, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04515, Choline_transpo, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R798-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDERKNGAY GTPQKYDPTF KGPIYNRGCT DIICCVFLLL AIVGYVAVGI
60 70 80 90 100
IAWTHGDPRK VIYPTDSRGE FCGQKGTKNE NKPYLFYFNI VKCASPLVLL
110 120 130 140 150
EFQCPTPQIC VEKCPDRYLT YLNARSSRDF EYYKQFCVPG FKNNKGVAEV
160 170 180 190 200
LRDGDCPAVL IPSKPLARRC FPAIHAYKGV LMVGNETTYE DGHGSRKNIT
210 220 230 240 250
DLVEGAKKAN GVLEARQLAM RIFEDYTVSW YWIIIGLVIA MAMSLLFIIL
260 270 280 290 300
LRFLAGIMVW VMIIMVILVL GYGIFHCYME YSRLRGEAGS DVSLVDLGFQ
310 320 330 340 350
TDFRVYLHLR QTWLAFMIIL SILEVIIILL LIFLRKRILI AIALIKEASR
360 370 380 390 400
AVGYVMCSLL YPLVTFFLLC LCIAYWASTA VFLSTSNEAV YKIFDDSPCP
410 420 430 440 450
FTAKTCNPET FPSSNESRQC PNARCQFAFY GGESGYHRAL LGLQIFNAFM
460 470 480 490 500
FFWLANFVLA LGQVTLAGAF ASYYWALRKP DDLPAFPLFS AFGRALRYHT
510 520 530 540 550
GSLAFGALIL AIVQIIRVIL EYLDQRLKAA ENKFAKCLMT CLKCCFWCLE
560 570 580 590 600
KFIKFLNRNA YIMIAIYGTN FCTSARNAFF LLMRNIIRVA VLDKVTDFLF
610 620 630 640 650
LLGKLLIVGS VGILAFFFFT HRIRIVQDTA PPLNYYWVPI LTVIVGSYLI
660 670 680 690 700
AHGFFSVYGM CVDTLFLCFL EDLERNDGSA ERPYFMSSTL KKLLNKTNKK

AAES
Length:704
Mass (Da):79,874
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B8A0B8EF040CDD6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KM024996 Genomic DNA Translation: AIN81053.1
KM024999 Genomic DNA Translation: AIN81056.1
KM025000 Genomic DNA Translation: AIN81057.1
KM025001 Genomic DNA Translation: AIN81058.1
KM025002 Genomic DNA Translation: AIN81059.1
KM025003 Genomic DNA Translation: AIN81060.1
KM025004 Genomic DNA Translation: AIN81061.1
KM025005 Genomic DNA Translation: AIN81062.1
KM025006 Genomic DNA Translation: AIN81063.1
KM025007 Genomic DNA Translation: AIN81064.1
KM025008 Genomic DNA Translation: AIN81065.1
KM025009 Genomic DNA Translation: AIN81066.1
KM025010 Genomic DNA Translation: AIN81067.1
KM025011 Genomic DNA Translation: AIN81068.1
KM025012 Genomic DNA Translation: AIN81069.1
KM025013 Genomic DNA Translation: AIN81070.1
KM025014 Genomic DNA Translation: AIN81071.1
KM025015 Genomic DNA Translation: AIN81072.1
KM025016 Genomic DNA Translation: AIN81073.1
KM025017 Genomic DNA Translation: AIN81074.1
KM025018 Genomic DNA Translation: AIN81075.1
KM025019 Genomic DNA Translation: AIN81076.1
KM025020 Genomic DNA Translation: AIN81077.1
KM025022 Genomic DNA Translation: AIN81079.1
KM025023 Genomic DNA Translation: AIN81080.1
KM025024 Genomic DNA Translation: AIN81081.1
KM025025 Genomic DNA Translation: AIN81082.1
CH471106 Genomic DNA Translation: EAW84127.1
CH471106 Genomic DNA Translation: EAW84128.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM024996 Genomic DNA Translation: AIN81053.1
KM024999 Genomic DNA Translation: AIN81056.1
KM025000 Genomic DNA Translation: AIN81057.1
KM025001 Genomic DNA Translation: AIN81058.1
KM025002 Genomic DNA Translation: AIN81059.1
KM025003 Genomic DNA Translation: AIN81060.1
KM025004 Genomic DNA Translation: AIN81061.1
KM025005 Genomic DNA Translation: AIN81062.1
KM025006 Genomic DNA Translation: AIN81063.1
KM025007 Genomic DNA Translation: AIN81064.1
KM025008 Genomic DNA Translation: AIN81065.1
KM025009 Genomic DNA Translation: AIN81066.1
KM025010 Genomic DNA Translation: AIN81067.1
KM025011 Genomic DNA Translation: AIN81068.1
KM025012 Genomic DNA Translation: AIN81069.1
KM025013 Genomic DNA Translation: AIN81070.1
KM025014 Genomic DNA Translation: AIN81071.1
KM025015 Genomic DNA Translation: AIN81072.1
KM025016 Genomic DNA Translation: AIN81073.1
KM025017 Genomic DNA Translation: AIN81074.1
KM025018 Genomic DNA Translation: AIN81075.1
KM025019 Genomic DNA Translation: AIN81076.1
KM025020 Genomic DNA Translation: AIN81077.1
KM025022 Genomic DNA Translation: AIN81079.1
KM025023 Genomic DNA Translation: AIN81080.1
KM025024 Genomic DNA Translation: AIN81081.1
KM025025 Genomic DNA Translation: AIN81082.1
CH471106 Genomic DNA Translation: EAW84127.1
CH471106 Genomic DNA Translation: EAW84128.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA0A024R798

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC44A2, human

Family and domain databases

InterProiView protein in InterPro
IPR007603, Choline_transptr-like
PANTHERiPTHR12385, PTHR12385, 1 hit
PfamiView protein in Pfam
PF04515, Choline_transpo, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R798_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R798
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 7, 2020
This is version 24 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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