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UniProtKB - A0A024R796 (A0A024R796_HUMAN)
Protein
Submitted name:
Cyclin-dependent kinase inhibitor 2D (P19, inhibits CDK4), isoform CRA_a
Gene
CDKN2D
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- kinase activity Source: UniProtKB-KW
- protein kinase binding Source: Ensembl
GO - Biological processi
- negative regulation of cell cycle G1/S phase transition Source: Ensembl
- sensory perception of sound Source: Ensembl
Keywordsi
Molecular function | KinaseImported, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: Cyclin-dependent kinase inhibitor 2D (P19, inhibits CDK4), isoform CRA_aImported |
Gene namesi | Name:CDKN2DImported ORF Names:hCG_28483Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000129355 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- cyclin D2-CDK4 complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000129355, Expressed in bone marrow and 179 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 73 – 105 | ANKPROSITE-ProRule annotationAdd BLAST | 33 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationPhylogenomic databases
HOGENOMi | CLU_000134_37_0_1 |
OMAi | LHQEFVH |
OrthoDBi | 1453965at2759 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R796-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLEEVRAGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM
60 70 80 90 100
FGSTAIALEL LKQGASPNVQ DTSGTSPVHD AARTGFLDTL KVLVEHGADV
110 120 130 140 150
NVPDGTGALP IHLAVQEGHT AVVSFLAAES DLHRRDARGL TPLELALQRG
160
AQDLVDILQG HMVAPL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471106 Genomic DNA Translation: EAW84122.1 CH471106 Genomic DNA Translation: EAW84123.1 |
RefSeqi | NP_001791.1, NM_001800.3 NP_524145.1, NM_079421.2 |
Genome annotation databases
GeneIDi | 1032 |
KEGGi | hsa:1032 |
MANE-Selecti | ENST00000393599.3; ENSP00000377224.1; NM_001800.4; NP_001791.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471106 Genomic DNA Translation: EAW84122.1 CH471106 Genomic DNA Translation: EAW84123.1 |
RefSeqi | NP_001791.1, NM_001800.3 NP_524145.1, NM_079421.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 4404, 296 antibodies from 34 providers |
DNASUi | 1032 |
Genome annotation databases
GeneIDi | 1032 |
KEGGi | hsa:1032 |
MANE-Selecti | ENST00000393599.3; ENSP00000377224.1; NM_001800.4; NP_001791.1 |
Organism-specific databases
CTDi | 1032 |
VEuPathDBi | HostDB:ENSG00000129355 |
Phylogenomic databases
HOGENOMi | CLU_000134_37_0_1 |
OMAi | LHQEFVH |
OrthoDBi | 1453965at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1032, 15 hits in 1086 CRISPR screens |
GenomeRNAii | 1032 |
Gene expression databases
Bgeei | ENSG00000129355, Expressed in bone marrow and 179 other tissues |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R796_HUMAN | |
Accessioni | A0A024R796Primary (citable) accession number: A0A024R796 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | May 25, 2022 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |