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Protein

V-type proton ATPase subunit a

Gene

ATP6V0A4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:ATP6V0A4Imported
ORF Names:hCG_16392Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000105929.15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei403 – 427HelicalUniRule annotationAdd BLAST25
Transmembranei447 – 466HelicalUniRule annotationAdd BLAST20
Transmembranei545 – 566HelicalUniRule annotationAdd BLAST22
Transmembranei572 – 596HelicalUniRule annotationAdd BLAST25
Transmembranei642 – 661HelicalUniRule annotationAdd BLAST20
Transmembranei771 – 796HelicalUniRule annotationAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiA0A024R791

Expressioni

Gene expression databases

BgeeiENSG00000105929
ExpressionAtlasiA0A024R791 baseline and differential

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili93 – 127Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2189 Eukaryota
COG1269 LUCA
KOiK02154
OMAiFILRANH
OrthoDBiEOG091G01BI

Family and domain databases

InterProiView protein in InterPro
IPR002490 V-ATPase_116kDa_su
IPR026028 V-type_ATPase_116kDa_su_euka
PANTHERiPTHR11629 PTHR11629, 1 hit
PfamiView protein in Pfam
PF01496 V_ATPase_I, 1 hit
PIRSFiPIRSF001293 ATP6V0A1, 1 hit

Sequencei

Sequence statusi: Complete.

A0A024R791-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVFRSEEM CLSQLFLQVE AAYCCVAELG ELGLVQFKDL NMNVNSFQRK
60 70 80 90 100
FVNEVRRCES LERILRFLED EMQNEIVVQL LEKSPLTPLP REMITLETVL
110 120 130 140 150
EKLEGELQEA NQNQQALKQS FLELTELKYL LKKTQDFFET ETNLADDFFT
160 170 180 190 200
EDTSGLLELK AVPAYMTGKL GFIAGVINRE RMASFERLLW RICRGNVYLK
210 220 230 240 250
FSEMDAPLED PVTKEEIQKN IFIIFYQGEQ LRQKIKKICD GFRATVYPCP
260 270 280 290 300
EPAVERREML ESVNVRLEDL ITVITQTESH RQRLLQEAAA NWHSWLIKVQ
310 320 330 340 350
KMKAVYHILN MCNIDVTQQC VIAEIWFPVA DATRIKRALE QGMELSGSSM
360 370 380 390 400
APIMTTVQSK TAPPTFNRTN KFTAGFQNIV DAYGVGSYRE INPAPYTIIT
410 420 430 440 450
FPFLFAVMFG DCGHGTVMLL AALWMILNER RLLSQKTDNE IWNTFFHGRY
460 470 480 490 500
LILLMGIFSI YTGLIYNDCF SKSLNIFGSS WSVQPMFRNG TWNTHVMEES
510 520 530 540 550
LYLQLDPAIP GVYFGNPYPF GIDPIWNLAS NKLTFLNSYK MKMSVILGIV
560 570 580 590 600
QMVFGVILSL FNHIYFRRTL NIILQFIPEM IFILCLFGYL VFMIIFKWCC
610 620 630 640 650
FDVHVSQHAP SILIHFINMF LFNYSDSSNA PLYKHQQEVQ SFFVVMALIS
660 670 680 690 700
VPWMLLIKPF ILRASHRKSQ LQASRIQEDA TENIEGDSSS PSSRSGQRTS
710 720 730 740 750
ADTHGALDDH GEEFNFGDVF VHQAIHTIEY CLGCISNTAS YLRLWALSLA
760 770 780 790 800
HAQLSEVLWT MVMNSGLQTR GWGGIVGVFI IFAVFAVLTV AILLIMEGLS
810 820 830 840
AFLHALRLHW VEFQNKFYVG DGYKFSPFSF KHILDGTAEE
Length:840
Mass (Da):96,386
Last modified:July 9, 2014 - v1
Checksum:i449964EBC01D4649
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471070 Genomic DNA Translation: EAW83893.1
CH471070 Genomic DNA Translation: EAW83894.1
CH471070 Genomic DNA Translation: EAW83895.1
CH471070 Genomic DNA Translation: EAW83896.1
RefSeqiNP_065683.2, NM_020632.2
NP_570855.2, NM_130840.2
NP_570856.2, NM_130841.2
XP_005250450.1, XM_005250393.1
XP_005250451.1, XM_005250394.3
UniGeneiHs.98967

Genome annotation databases

GeneIDi50617
KEGGihsa:50617

Similar proteinsi

Entry informationi

Entry nameiA0A024R791_HUMAN
AccessioniPrimary (citable) accession number: A0A024R791
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: May 23, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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