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UniProtKB - A0A024R752 (A0A024R752_HUMAN)
Protein
Submitted name:
Forkhead box P2, isoform CRA_f
Gene
FOXP2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 412 – 485 | Fork-headPROSITE-ProRule annotationAdd BLAST | 74 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- animal organ development Source: UniProt
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotation, RepressorARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Forkhead box P2, isoform CRA_fImported |
Gene namesi | Name:FOXP2Imported ORF Names:hCG_1813384Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000128573, Expressed in stomach and 199 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 412 – 485 | Fork-headInterPro annotationAdd BLAST | 74 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 189 – 246 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 346 – 373 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 557 – 576 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 586 – 623 | DisorderedSequence analysisAdd BLAST | 38 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 49 – 99 | Sequence analysisAdd BLAST | 51 | |
Coiled coili | 296 – 316 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 196 – 235 | Polar residuesSequence analysisAdd BLAST | 40 | |
Compositional biasi | 558 – 573 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 609 – 623 | Acidic residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerARBA annotationFamily and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R752-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMTPQVITPQ QMQQILQQQV LSPQQLQALL QQQQAVMLQQ QQLQEFYKKQ
60 70 80 90 100
QEQLHLQLLQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQH
110 120 130 140 150
PGKQAKEQQQ QQQQQQQLAA QQLVFQQQLL QMQQLQQQQH LLSLQRQGLI
160 170 180 190 200
SIPPGQAALP VQSLPQAGLS PAEIQQLWKE VTGVHSMEDN GIKHGGLDLT
210 220 230 240 250
TNNSSSTTSS NTSKASPPIT HHSIVNGQSS VLSARRDSSS HEETGASHTL
260 270 280 290 300
YGHGVCKWPG CESICEDFGQ FLKHLNNEHA LDDRSTAQCR VQMQVVQQLE
310 320 330 340 350
IQLSKERERL QAMMTHLHMR PSEPKPSPKP LNLVSSVTMS KNMLETSPQS
360 370 380 390 400
LPQTPTTPTA PVTPITQGPS VITPASVPNV GAIRRRHSDK YNIPMSSEIA
410 420 430 440 450
PNYEFYKNAD VRPPFTYATL IRQAIMESSD RQLTLNEIYS WFTRTFAYFR
460 470 480 490 500
RNAATWKNAV RHNLSLHKCF VRVENVKGAV WTVDEVEYQK RRSQKITGSP
510 520 530 540 550
TLVKNIPTSL GYGAALNASL QAALAESSLP LLSNPGLINN ASSGLLQAVH
560 570 580 590 600
EDLNGSLDHI DSNGNSSPGC SPQPHIHSIH VKEEPVIAED EDCPMSLVTT
610 620
ANHSPELEDD REIEEEPLSE DLE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471070 Genomic DNA Translation: EAW83485.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471070 Genomic DNA Translation: EAW83485.1 |
3D structure databases
SMRi | A0A024R752 |
ModBasei | Search... |
Miscellaneous databases
ChiTaRSi | FOXP2, human |
Gene expression databases
Bgeei | ENSG00000128573, Expressed in stomach and 199 other tissues |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R752_HUMAN | |
Accessioni | A0A024R752Primary (citable) accession number: A0A024R752 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | January 19, 2022 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |