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Entry version 54 (07 Oct 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Nuclear factor of activated T-cells 5, tonicity-responsive, isoform CRA_b

Gene

NFAT5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorARBA annotation, DNA-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear factor of activated T-cells 5, tonicity-responsive, isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFAT5Imported
ORF Names:hCG_26653Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000102908.20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102908, Expressed in kidney and 223 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A0A024R734

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini188 – 367RHDInterPro annotationAdd BLAST180

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni40 – 87DisorderedSequence analysisAdd BLAST48
Regioni99 – 144DisorderedSequence analysisAdd BLAST46
Regioni165 – 189DisorderedSequence analysisAdd BLAST25
Regioni564 – 590DisorderedSequence analysisAdd BLAST27
Regioni765 – 815DisorderedSequence analysisAdd BLAST51
Regioni882 – 920DisorderedSequence analysisAdd BLAST39
Regioni1135 – 1228DisorderedSequence analysisAdd BLAST94
Regioni1240 – 1295DisorderedSequence analysisAdd BLAST56
Regioni1397 – 1426DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi40 – 62PolarSequence analysisAdd BLAST23
Compositional biasi99 – 119PolarSequence analysisAdd BLAST21
Compositional biasi165 – 185PolarSequence analysisAdd BLAST21
Compositional biasi765 – 779PolarSequence analysisAdd BLAST15
Compositional biasi792 – 815PolarSequence analysisAdd BLAST24
Compositional biasi1143 – 1206PolarSequence analysisAdd BLAST64

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR008366, NFAT
IPR015646, NFAT5
IPR008967, p53-like_TF_DNA-bd
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12533, PTHR12533, 1 hit
PTHR12533:SF10, PTHR12533:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01789, NUCFACTORATC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429, IPT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50254, REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R734-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGACSSFTT SSSPTIYSTS VTDSKAMQVE SCSSAVGVSN RGVSEKQLTS
60 70 80 90 100
NTVQQHPSTP KRHTVLYISP PPEDLLDNSR MSCQDEGCGL ESEQSCSMWM
110 120 130 140 150
EDSPSNFSNM STSSYNDNTE VPRKSRKRNP KQRPGVKRRD CEESNMDIFD
160 170 180 190 200
ADSAKAPHYV LSQLTTDNKG NSKAGNGTLE NQKGTGVKKS PMLCGQYPVK
210 220 230 240 250
SEGKELKIVV QPETQHRARY LTEGSRGSVK DRTQQGFPTV KLEGHNEPVV
260 270 280 290 300
LQVFVGNDSG RVKPHGFYQA CRVTGRNTTP CKEVDIEGTT VIEVGLDPSN
310 320 330 340 350
NMTLAVDCVG ILKLRNADVE ARIGIAGSKK KSTRARLVFR VNIMRKDGST
360 370 380 390 400
LTLQTPSSPI LCTQPAGVPE ILKKSLHSCS VKGEEEVFLI GKNFLKGTKV
410 420 430 440 450
IFQENVSDEN SWKSEAEIDM ELFHQNHLIV KVPPYHDQHI TLPVSVGIYV
460 470 480 490 500
VTNAGRSHDV QPFTYTPDPA AAGALNVNVK KEISSPARPC SFEEAMKAMK
510 520 530 540 550
TTGCNLDKVN IIPNALMTPL IPSSMIKSED VTPMEVTAEK RSSTIFKTTK
560 570 580 590 600
SVGSTQQTLE NISNIAGNGS FSSPSSSHLP SENEKQQQIQ PKAYNPETLT
610 620 630 640 650
TIQTQDISQP GTFPAVSASS QLPNSDALLQ QATQFQTRET QSREILQSDG
660 670 680 690 700
TVVNLSQLTE ASQQQQQSPL QEQAQTLQQQ ISSNIFPSPN SVSQLQNTIQ
710 720 730 740 750
QLQAGSFTGS TASGSSGSVD LVQQVLEAQQ QLSSVLFSAP DGNENVQEQL
760 770 780 790 800
SADIFQQVSQ IQSGVSPGMF SSTEPTVHTR PDNLLPGRAE SVHPQSENTL
810 820 830 840 850
SNQQQQQQQQ QQVMESSAAM VMEMQQSICQ AAAQIQSELF PSTASANGNL
860 870 880 890 900
QQSPVYQQTS HMMSALSTNE DMQMQCELFS SPPAVSGNET STTTTQQVAT
910 920 930 940 950
PGTTMFQTSS SGDGEETGTQ AKQIQNSVFQ TMVQMQHSGD NQPQVNLFSS
960 970 980 990 1000
TKSMMSVQNS GTQQQGNGLF QQGNEMMSLQ SGNFLQQSSH SQAQLFHPQN
1010 1020 1030 1040 1050
PIADAQNLSQ ETQGSLFHSP NPIVHSQTST TSSEQMQPPM FHSQSTIAVL
1060 1070 1080 1090 1100
QGSSVPQDQQ STNIFLSQSP MNNLQTNTVA QEAFFAAPNS ISPLQSTSNS
1110 1120 1130 1140 1150
EQQAAFQQQA PISHIQTPML SQEQAQPPQQ GLFQPQVALG SLPPNPMPQS
1160 1170 1180 1190 1200
QQGTMFQSQH SIVAMQSNSP SQEQQQQQQQ QQQQQQQQQQ SILFSNQNTM
1210 1220 1230 1240 1250
ATMASPKQPP PNMIFNPNQN PMANQEQQNQ SIFHQQSNMA PMNQEQQPMQ
1260 1270 1280 1290 1300
FQSQSTVSSL QNPGPTQSES SQTPLFHSSP QIQLVQGSPS SQEQQVTLFL
1310 1320 1330 1340 1350
SPASMSALQT SINQQDMQQS PLYSPQNNMP GIQGATSSPQ PQATLFHNTA
1360 1370 1380 1390 1400
GGTMNQLQNS PGSSQQTSGM FLFGIQNNCS QLLTSGPATL PDQLMAISQP
1410 1420 1430 1440 1450
GQPQNEGQPP VTTLLSQQMP ENSPLASSIN TNQNIEKIDL LVSLQNQGNN

LTGSF
Length:1,455
Mass (Da):157,983
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FA637348EAC0041
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471092 Genomic DNA Translation: EAW83278.1
CH471092 Genomic DNA Translation: EAW83279.1
CH471092 Genomic DNA Translation: EAW83280.1

NCBI Reference Sequences

More...
RefSeqi
NP_619728.2, NM_138714.3
NP_775321.1, NM_173214.2
NP_775322.1, NM_173215.2
XP_011521120.1, XM_011522818.2
XP_016878359.1, XM_017022870.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10725

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471092 Genomic DNA Translation: EAW83278.1
CH471092 Genomic DNA Translation: EAW83279.1
CH471092 Genomic DNA Translation: EAW83280.1
RefSeqiNP_619728.2, NM_138714.3
NP_775321.1, NM_173214.2
NP_775322.1, NM_173215.2
XP_011521120.1, XM_011522818.2
XP_016878359.1, XM_017022870.1

3D structure databases

SMRiA0A024R734
ModBaseiSearch...

Genome annotation databases

GeneIDi10725

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10725
EuPathDBiHostDB:ENSG00000102908.20

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10725, 8 hits in 894 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NFAT5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10725

Gene expression databases

BgeeiENSG00000102908, Expressed in kidney and 223 other tissues

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR008366, NFAT
IPR015646, NFAT5
IPR008967, p53-like_TF_DNA-bd
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf
PANTHERiPTHR12533, PTHR12533, 1 hit
PTHR12533:SF10, PTHR12533:SF10, 1 hit
PfamiView protein in Pfam
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit
PRINTSiPR01789, NUCFACTORATC
SMARTiView protein in SMART
SM00429, IPT, 1 hit
SUPFAMiSSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50254, REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R734_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R734
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 7, 2020
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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