UniProtKB - A0A024R728 (A0A024R728_HUMAN)
Protein
HGF/SF receptor
Gene
MET
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Catalytic activityi
- EC:2.7.10.1ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1128 | ATPUniRule annotation | 1 | |
Active sitei | 1222 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1102 – 1110 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- semaphorin receptor activity Source: InterPro
- transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC
GO - Biological processi
- transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Keywordsi
Molecular function | Kinase, ReceptorImportedARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: HGF/SF receptorARBA annotation (EC:2.7.10.1ARBA annotation)Alternative name(s): Hepatocyte growth factor receptorARBA annotation Proto-oncogene c-MetARBA annotation Scatter factor receptorARBA annotation Tyrosine-protein kinase MetARBA annotation |
Gene namesi | Name:METImported ORF Names:hCG_38705Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000105976.14 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 949 – 973 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5014214243 | 25 – 1408 | HGF/SF receptorSequence analysisAdd BLAST | 1384 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1252 | Phosphotyrosine; by autocatalysisUniRule annotation | 1 | |
Modified residuei | 1253 | Phosphotyrosine; by autocatalysisUniRule annotation | 1 | |
Modified residuei | 1367 | Phosphotyrosine; by autocatalysisUniRule annotation | 1 | |
Modified residuei | 1374 | Phosphotyrosine; by autocatalysisUniRule annotation | 1 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotation, Ubl conjugationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000105976, Expressed in pigmented layer of retina and 220 other tissues |
ExpressionAtlasi | A0A024R728, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 515 | SemaInterPro annotationAdd BLAST | 489 | |
Domaini | 1096 – 1363 | Protein kinaseInterPro annotationAdd BLAST | 268 |
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
OMAi | DEEPGQC |
OrthoDBi | 408584at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR011009, Kinase-like_dom_sf IPR031148, Plexin IPR002165, Plexin_repeat IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016201, PSI IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016244, Tyr_kinase_HGF/MSP_rcpt IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 1 hit |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF01437, PSI, 1 hit PF01403, Sema, 1 hit PF01833, TIG, 3 hits |
PIRSFi | PIRSF000617, TyrPK_HGF-R, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00429, IPT, 4 hits SM00423, PSI, 1 hit SM00630, Sema, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF56112, SSF56112, 1 hit SSF81296, SSF81296, 3 hits |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS51004, SEMA, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R728-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKAPAVLAPG ILVLLFTLVQ RSNGECKEAL AKSEMNVNMK YQLPNFTAET
60 70 80 90 100
PIQNVILHEH HIFLGATNYI YVLNEEDLQK VAEYKTGPVL EHPDCFPCQD
110 120 130 140 150
CSSKANLSGG VWKDNINMAL VVDTYYDDQL ISCGSVNRGT CQRHVFPHNH
160 170 180 190 200
TADIQSEVHC IFSPQIEEPS QCPDCVVSAL GAKVLSSVKD RFINFFVGNT
210 220 230 240 250
INSSYFPDHP LHSISVRRLK ETKDGFMFLT DQSYIDVLPE FRDSYPIKYV
260 270 280 290 300
HAFESNNFIY FLTVQRETLD AQTFHTRIIR FCSINSGLHS YMEMPLECIL
310 320 330 340 350
TEKRKKRSTK KEVFNILQAA YVSKPGAQLA RQIGASLNDD ILFGVFAQSK
360 370 380 390 400
PDSAEPMDRS AMCAFPIKYV NDFFNKIVNK NNVRCLQHFY GPNHEHCFNR
410 420 430 440 450
TLLRNSSGCE ARRDEYRTEF TTALQRVDLF MGQFSEVLLT SISTFIKGDL
460 470 480 490 500
TIANLGTSEG RFMQVVVSRS GPSTPHVNFL LDSHPVSPEV IVEHTLNQNG
510 520 530 540 550
YTLVITGKKI TKIPLNGLGC RHFQSCSQCL SAPPFVQCGW CHDKCVRSEE
560 570 580 590 600
CLSGTWTQQI CLPAIYKVFP NSAPLEGGTR LTICGWDFGF RRNNKFDLKK
610 620 630 640 650
TRVLLGNESC TLTLSESTMN TLKCTVGPAM NKHFNMSIII SNGHGTTQYS
660 670 680 690 700
TFSYVDPVIT SISPKYGPMA GGTLLTLTGN YLNSGNSRHI SIGGKTCTLK
710 720 730 740 750
SVSNSILECY TPAQTISTEF AVKLKIDLAN RETSIFSYRE DPIVYEIHPT
760 770 780 790 800
KSFISTWWKE PLNIVSFLFC FASGGSTITG VGKNLNSVSV PRMVINVHEA
810 820 830 840 850
GRNFTVACQH RSNSEIICCT TPSLQQLNLQ LPLKTKAFFM LDGILSKYFD
860 870 880 890 900
LIYVHNPVFK PFEKPVMISM GNENVLEIKG NDIDPEAVKG EVLKVGNKSC
910 920 930 940 950
ENIHLHSEAV LCTVPNDLLK LNSELNIEWK QAISSTVLGK VIVQPDQNFT
960 970 980 990 1000
GLIAGVVSIS TALLLLLGFF LWLKKRKQIK DLGSELVRYD ARVHTPHLDR
1010 1020 1030 1040 1050
LVSARSVSPT TEMVSNESVD YRATFPEDQF PNSSQNGSCR QVQYPLTDMS
1060 1070 1080 1090 1100
PILTSGDSDI SSPLLQNTVH IDLSALNPEL VQAVQHVVIG PSSLIVHFNE
1110 1120 1130 1140 1150
VIGRGHFGCV YHGTLLDNDG KKIHCAVKSL NRITDIGEVS QFLTEGIIMK
1160 1170 1180 1190 1200
DFSHPNVLSL LGICLRSEGS PLVVLPYMKH GDLRNFIRNE THNPTVKDLI
1210 1220 1230 1240 1250
GFGLQVAKGM KYLASKKFVH RDLAARNCML DEKFTVKVAD FGLARDMYDK
1260 1270 1280 1290 1300
EYYSVHNKTG AKLPVKWMAL ESLQTQKFTT KSDVWSFGVL LWELMTRGAP
1310 1320 1330 1340 1350
PYPDVNTFDI TVYLLQGRRL LQPEYCPDPL YEVMLKCWHP KAEMRPSFSE
1360 1370 1380 1390 1400
LVSRISAIFS TFIGEHYVHV NATYVNVKCV APYPSLLSSE DNADDEVDTR
PASFWETS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471070 Genomic DNA Translation: EAW83507.1 CH471070 Genomic DNA Translation: EAW83511.1 |
RefSeqi | NP_001120972.1, NM_001127500.2 |
Genome annotation databases
GeneIDi | 4233 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471070 Genomic DNA Translation: EAW83507.1 CH471070 Genomic DNA Translation: EAW83511.1 |
RefSeqi | NP_001120972.1, NM_001127500.2 |
3D structure databases
SMRi | A0A024R728 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024R728 |
Protocols and materials databases
Antibodypediai | 3939, 3023 antibodies |
DNASUi | 4233 |
Genome annotation databases
GeneIDi | 4233 |
Organism-specific databases
CTDi | 4233 |
VEuPathDBi | HostDB:ENSG00000105976.14 |
Phylogenomic databases
OMAi | DEEPGQC |
OrthoDBi | 408584at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4233, 29 hits in 1028 CRISPR screens |
ChiTaRSi | MET, human |
GenomeRNAii | 4233 |
Gene expression databases
Bgeei | ENSG00000105976, Expressed in pigmented layer of retina and 220 other tissues |
ExpressionAtlasi | A0A024R728, baseline and differential |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR011009, Kinase-like_dom_sf IPR031148, Plexin IPR002165, Plexin_repeat IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016201, PSI IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016244, Tyr_kinase_HGF/MSP_rcpt IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 1 hit |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF01437, PSI, 1 hit PF01403, Sema, 1 hit PF01833, TIG, 3 hits |
PIRSFi | PIRSF000617, TyrPK_HGF-R, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00429, IPT, 4 hits SM00423, PSI, 1 hit SM00630, Sema, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF56112, SSF56112, 1 hit SSF81296, SSF81296, 3 hits |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS51004, SEMA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R728_HUMAN | |
Accessioni | A0A024R728Primary (citable) accession number: A0A024R728 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | April 7, 2021 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |