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Protein
Submitted name:

Vacuolar protein sorting 4A (Yeast), isoform CRA_c

Gene

VPS4A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolar protein sorting 4A (Yeast), isoform CRA_cImported
Gene namesi
Name:VPS4AImported
ORF Names:hCG_28199Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000132612.15

PTM / Processingi

Proteomic databases

PRIDEiA0A024R705

Expressioni

Gene expression databases

BgeeiENSG00000132612 Expressed in 228 organ(s), highest expression level in vagina
ExpressionAtlasiA0A024R705 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A024R705
SMRiA0A024R705
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 80MITInterPro annotationAdd BLAST79
Domaini159 – 295AAAInterPro annotationAdd BLAST137

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 35Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0739 Eukaryota
ENOG410XRHN LUCA
KOiK12196
OMAiVKQLFTM
OrthoDBiEOG091G0Q8J
PhylomeDBiA0A024R705

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR027417 P-loop_NTPase
IPR015415 Vps4_C
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF04212 MIT, 1 hit
PF09336 Vps4_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00745 MIT, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A024R705-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTSTLQKAI DLVTKATEED KAKNYEEALR LYQHAVEYFL HAIKYEAHSD
60 70 80 90 100
KAKESIRAKC VQYLDRAEKL KDYLRSKEKH GKKPVKENQS EGKGSDSDSE
110 120 130 140 150
GDNPEKKKLQ EQLMGAVVME KPNIRWNDVA GLEGAKEALK EAVILPIKFP
160 170 180 190 200
HLFTGKRTPW RGILLFGPPG TGKSYLAKAV ATEANNSTFF SVSSSDLMSK
210 220 230 240 250
WLGESEKLVK NLFELARQHK PSIIFIDEVD SLCGSRNENE SEAARRIKTE
260 270 280 290 300
FLVQMQGVGN NNDGTLVLGA TNIPWVLDSA IRRRFEKRIY IPLPEEAARA
310 320 330 340 350
QMFRLHLGST PHNLTDANIH ELARKTEGYS GADISIIVRD SLMQPVRKVQ
360 370 380 390 400
SATHFKKVCG PSRTNPSMMI DDLLTPCSPG DPGAMEMTWM DVPGDKLLEP
410 420 430
VVCMSDMLRS LATTRPTVNA DDLLKVKKFS EDFGQES
Length:437
Mass (Da):48,898
Last modified:July 9, 2014 - v1
Checksum:iC3CC556FB84F105C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471092 Genomic DNA Translation: EAW83264.1
RefSeqiNP_037377.1, NM_013245.2
UniGeneiHs.128420

Genome annotation databases

GeneIDi27183
KEGGihsa:27183

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471092 Genomic DNA Translation: EAW83264.1
RefSeqiNP_037377.1, NM_013245.2
UniGeneiHs.128420

3D structure databases

ProteinModelPortaliA0A024R705
SMRiA0A024R705
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA0A024R705

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi27183
KEGGihsa:27183

Organism-specific databases

CTDi27183
EuPathDBiHostDB:ENSG00000132612.15

Phylogenomic databases

eggNOGiKOG0739 Eukaryota
ENOG410XRHN LUCA
KOiK12196
OMAiVKQLFTM
OrthoDBiEOG091G0Q8J
PhylomeDBiA0A024R705

Miscellaneous databases

ChiTaRSiVPS4A human
GenomeRNAii27183

Gene expression databases

BgeeiENSG00000132612 Expressed in 228 organ(s), highest expression level in vagina
ExpressionAtlasiA0A024R705 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR027417 P-loop_NTPase
IPR015415 Vps4_C
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF04212 MIT, 1 hit
PF09336 Vps4_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00745 MIT, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R705_HUMAN
AccessioniPrimary (citable) accession number: A0A024R705
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 7, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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