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Protein
Submitted name:

Matrix metallopeptidase 15 (Membrane-inserted), isoform CRA_a

Gene

MMP15

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Zn2+SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei260UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, MetalloproteaseSAAS annotation, Protease
LigandCalciumSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Matrix metallopeptidase 15 (Membrane-inserted), isoform CRA_aImported
Gene namesi
Name:MMP15Imported
ORF Names:hCG_16484Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000102996.4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei626 – 647HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 45Sequence analysisAdd BLAST45
ChainiPRO_501421423446 – 669Sequence analysisAdd BLAST624

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000102996 Expressed in 149 organ(s), highest expression level in heart left ventricle

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 305ZnMcInterPro annotationAdd BLAST171
Repeati367 – 415HemopexinPROSITE-ProRule annotationAdd BLAST49
Repeati416 – 461HemopexinPROSITE-ProRule annotationAdd BLAST46
Repeati463 – 511HemopexinPROSITE-ProRule annotationAdd BLAST49
Repeati512 – 559HemopexinPROSITE-ProRule annotationAdd BLAST48

Sequence similaritiesi

Belongs to the peptidase M10A family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
KOiK07995
OMAiMQRKGAP
OrthoDBiEOG091G03DP

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028729 MMP15
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021805 Pept_M10A_metallopeptidase_C
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
PANTHERiPTHR10201:SF25 PTHR10201:SF25, 1 hit
PfamiView protein in Pfam
PF11857 DUF3377, 1 hit
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

A0A024R6U8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSDPSAPGR PGWTGSLLGD REEAARPRLL PLLLVLLGCL GLGVAAEDAE
60 70 80 90 100
VHAENWLRLY GYLPQPSRHM STMRSAQILA SALAEMQRFY GIPVTGVLDE
110 120 130 140 150
ETKEWMKRPR CGVPDQFGVR VKANLRRRRK RYALTGRKWN NHHLTFSIQN
160 170 180 190 200
YTEKLGWYHS MEAVRRAFRV WEQATPLVFQ EVPYEDIRLR RQKEADIMVL
210 220 230 240 250
FASGFHGDSS PFDGTGGFLA HAYFPGPGLG GDTHFDADEP WTFSSTDLHG
260 270 280 290 300
NNLFLVAVHE LGHALGLEHS SNPNAIMAPF YQWKDVDNFK LPEDDLRGIQ
310 320 330 340 350
QLYGTPDGQP QPTQPLPTVT PRRPGRPDHR PPRPPQPPPP GGKPERPPKP
360 370 380 390 400
GPPVQPRATE RPDQYGPNIC DGDFDTVAML RGEMFVFKGR WFWRVRHNRV
410 420 430 440 450
LDNYPMPIGH FWRGLPGDIS AAYERQDGRF VFFKGDRYWL FREANLEPGY
460 470 480 490 500
PQPLTSYGLG IPYDRIDTAI WWEPTGHTFF FQEDRYWRFN EETQRGDPGY
510 520 530 540 550
PKPISVWQGI PASPKGAFLS NDAAYTYFYK GTKYWKFDNE RLRMEPGYPK
560 570 580 590 600
SILRDFMGCQ EHVEPGPRWP DVARPPFNPH GGAEPGADSA EGDVGDGDGD
610 620 630 640 650
FGAGVNKDGG SRVVVQMEEV ARTVNVVMVL VPLLLLLCVL GLTYALVQMQ
660
RKGAPRVLLY CKRSLQEWV
Length:669
Mass (Da):75,807
Last modified:July 9, 2014 - v1
Checksum:iFE875EC0674B297F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471092 Genomic DNA Translation: EAW82965.1
CH471092 Genomic DNA Translation: EAW82966.1
RefSeqiNP_002419.1, NM_002428.3
UniGeneiHs.80343

Genome annotation databases

GeneIDi4324
KEGGihsa:4324

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471092 Genomic DNA Translation: EAW82965.1
CH471092 Genomic DNA Translation: EAW82966.1
RefSeqiNP_002419.1, NM_002428.3
UniGeneiHs.80343

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4324
KEGGihsa:4324

Organism-specific databases

CTDi4324
EuPathDBiHostDB:ENSG00000102996.4

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
KOiK07995
OMAiMQRKGAP
OrthoDBiEOG091G03DP

Miscellaneous databases

GenomeRNAii4324

Gene expression databases

BgeeiENSG00000102996 Expressed in 149 organ(s), highest expression level in heart left ventricle

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028729 MMP15
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021805 Pept_M10A_metallopeptidase_C
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
PANTHERiPTHR10201:SF25 PTHR10201:SF25, 1 hit
PfamiView protein in Pfam
PF11857 DUF3377, 1 hit
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R6U8_HUMAN
AccessioniPrimary (citable) accession number: A0A024R6U8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 10, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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