UniProtKB - A0A024R6P0 (A0A024R6P0_HUMAN)
Protein
Submitted name:
Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 3, isoform CRA_c
Gene
SERPINA3
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 3, isoform CRA_cImported |
Gene namesi | Name:SERPINA3Imported ORF Names:hCG_2039549Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196136.16 HostDB:ENSG00000273259.2 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_5014214264 | 24 – 423 | Sequence analysisAdd BLAST | 400 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196136, Expressed in liver and 111 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 420 | SERPINInterPro annotationAdd BLAST | 363 |
Sequence similaritiesi
Belongs to the serpin family.UniRule annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_023330_2_1_1 |
OMAi | LCHPNSP |
OrthoDBi | 1124079at2759 |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R6P0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERMLPLLAL GLLAAGFCPA VLCHPNSPLD EENLTQENQD RGTHVDLGLA
60 70 80 90 100
SANVDFAFSL YKQLVLKAPD KNVIFSPLSI STALAFLSLG AHNTTLTEIL
110 120 130 140 150
KGLKFNLTET SEAEIHQSFQ HLLRTLNQSS DELQLSMGNA MFVKEQLSLL
160 170 180 190 200
DRFTEDAKRL YGSEAFATDF QDSAAAKKLI NDYVKNGTRG KITDLIKDLD
210 220 230 240 250
SQTMMVLVNY IFFKAKWEMP FDPQDTHQSR FYLSKKKWVM VPMMSLHHLT
260 270 280 290 300
IPYFRDEELS CTVVELKYTG NASALFILPD QDKMEEVEAM LLPETLKRWR
310 320 330 340 350
DSLEFREIGE LYLPKFSISR DYNLNDILLQ LGIEEAFTSK ADLSGITGAR
360 370 380 390 400
NLAVSQVVHK AVLDVFEEGT EASAATAVKI TLLSALVETR TIVRFNRPFL
410 420
MIIVPTDTQN IFFMSKVTNP KQA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471061 Genomic DNA Translation: EAW81589.1 CH471061 Genomic DNA Translation: EAW81590.1 |
RefSeqi | NP_001076.2, NM_001085.4 |
Genome annotation databases
GeneIDi | 12 |
KEGGi | hsa:12 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471061 Genomic DNA Translation: EAW81589.1 CH471061 Genomic DNA Translation: EAW81590.1 |
RefSeqi | NP_001076.2, NM_001085.4 |
3D structure databases
SMRi | A0A024R6P0 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 765, 546 antibodies |
Genome annotation databases
GeneIDi | 12 |
KEGGi | hsa:12 |
Organism-specific databases
CTDi | 12 |
EuPathDBi | HostDB:ENSG00000196136.16 HostDB:ENSG00000273259.2 |
Phylogenomic databases
HOGENOMi | CLU_023330_2_1_1 |
OMAi | LCHPNSP |
OrthoDBi | 1124079at2759 |
Miscellaneous databases
BioGRID-ORCSi | 12, 5 hits in 847 CRISPR screens |
ChiTaRSi | SERPINA3, human |
GenomeRNAii | 12 |
Gene expression databases
Bgeei | ENSG00000196136, Expressed in liver and 111 other tissues |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R6P0_HUMAN | |
Accessioni | A0A024R6P0Primary (citable) accession number: A0A024R6P0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |