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Protein
Submitted name:

Serine palmitoyltransferase, long chain base subunit 2, isoform CRA_a

Gene

SPTLC2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseImported
LigandPyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Serine palmitoyltransferase, long chain base subunit 2, isoform CRA_aImported
Gene namesi
Name:SPTLC2Imported
ORF Names:hCG_22264Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000100596.6

Expressioni

Gene expression databases

BgeeiENSG00000100596 Expressed in 219 organ(s), highest expression level in corpus callosum

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 528Aminotran_1_2InterPro annotationAdd BLAST360

Sequence similaritiesi

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1357 Eukaryota
COG0156 LUCA
KOiK00654
OMAiISQGQPK
OrthoDBiEOG091G0558

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A024R6H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPEPGGCCC RRTVRANGCV ANGEVRNGYV RSSAAAAAAA AAGQIHHVTQ
60 70 80 90 100
NGGLYKRPFN EAFEETPMLV AVLTYVGYGV LTLFGYLRDF LRYWRIEKCH
110 120 130 140 150
HATEREEQKD FVSLYQDFEN FYTRNLYMRI RDNWNRPICS VPGARVDIME
160 170 180 190 200
RQSHDYNWSF KYTGNIIKGV INMGSYNYLG FARNTGSCQE AAAKVLEEYG
210 220 230 240 250
AGVCSTRQEI GNLDKHEELE ELVARFLGVE AAMAYGMGFA TNSMNIPALV
260 270 280 290 300
GKGCLILSDE LNHASLVLGA RLSGATIRIF KHNNMQSLEK LLKDAIVYGQ
310 320 330 340 350
PRTRRPWKKI LILVEGIYSM EGSIVRLPEV IALKKKYKAY LYLDEAHSIG
360 370 380 390 400
ALGPTGRGVV EYFGLDPEDV DVMMGTFTKS FGASGGYIGG KKELIDYLRT
410 420 430 440 450
HSHSAVYATS LSPPVVEQII TSMKCIMGQD GTSLGKECVQ QLAENTRYFR
460 470 480 490 500
RRLKEMGFII YGNEDSPVVP LMLYMPAKIG AFGREMLKRN IGVVVVGFPA
510 520 530 540 550
TPIIESRARF CLSAAHTKEI LDTALKEIDE VGDLLQLKYS RHRLVPLLDR
560
PFDETTYEET ED
Length:562
Mass (Da):62,924
Last modified:July 9, 2014 - v1
Checksum:i0C1AA1E233DE36F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471061 Genomic DNA Translation: EAW81297.1
CH471061 Genomic DNA Translation: EAW81299.1
RefSeqiNP_004854.1, NM_004863.3
UniGeneiHs.435661

Genome annotation databases

GeneIDi9517
KEGGihsa:9517

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471061 Genomic DNA Translation: EAW81297.1
CH471061 Genomic DNA Translation: EAW81299.1
RefSeqiNP_004854.1, NM_004863.3
UniGeneiHs.435661

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9517
KEGGihsa:9517

Organism-specific databases

CTDi9517
EuPathDBiHostDB:ENSG00000100596.6

Phylogenomic databases

eggNOGiKOG1357 Eukaryota
COG0156 LUCA
KOiK00654
OMAiISQGQPK
OrthoDBiEOG091G0558

Miscellaneous databases

ChiTaRSiSPTLC2 human
GenomeRNAii9517

Gene expression databases

BgeeiENSG00000100596 Expressed in 219 organ(s), highest expression level in corpus callosum

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R6H1_HUMAN
AccessioniPrimary (citable) accession number: A0A024R6H1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 7, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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