UniProtKB - A0A024R6D3 (A0A024R6D3_HUMAN)
Protein
Submitted name:
Ectonucleoside triphosphate diphosphohydrolase 5, isoform CRA_d
Gene
ENTPD5
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 172 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 202 – 206 | ATPUniRule annotation | 5 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- hydrolase activity Source: UniProtKB-KW
Keywordsi
Molecular function | HydrolaseUniRule annotationImportedARBA annotation |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Ectonucleoside triphosphate diphosphohydrolase 5, isoform CRA_dImported |
Gene namesi | Name:ENTPD5Imported ORF Names:hCG_21714Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000187097.12 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5014214260 | 21 – 428 | Sequence analysisAdd BLAST | 408 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187097, Expressed in colon and 207 other tissues |
ExpressionAtlasi | A0A024R6D3, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_010246_0_2_1 |
OMAi | YEMPIDR |
OrthoDBi | 1337265at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000407, GDA1_CD39_NTPase |
PANTHERi | PTHR11782, PTHR11782, 1 hit |
Pfami | View protein in Pfam PF01150, GDA1_CD39, 1 hit |
PROSITEi | View protein in PROSITE PS01238, GDA1_CD39_NTPASE, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R6D3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATSWGTVFF MLVVSCVCSA VSHRNQQTWF EGIFLSSMCP INVSASTLYG
60 70 80 90 100
IMFDAGSTGT RIHVYTFVQK MPGQLPILEG EVFDSVKPGL SAFVDQPKQG
110 120 130 140 150
AETVQGLLEV AKDSIPRSHW KKTPVVLKAT AGLRLLPEHK AKALLFEVKE
160 170 180 190 200
IFRKSPFLVP KGSVSIMDGS DEGILAWVTV NFLTGQLHGH RQETVGTLDL
210 220 230 240 250
GGASTQITFL PQFEKTLEQT PRGYLTSFEM FNSTYKLYTH SYLGFGLKAA
260 270 280 290 300
RLATLGALET EGTDGHTFRS ACLPRWLEAE WIFGGVKYQY GGNQEGEVGF
310 320 330 340 350
EPCYAEVLRV VRGKLHQPEE VQRGSFYAFS YYYDRAVDTD MIDYEKGGIL
360 370 380 390 400
KVEDFERKAR EVCDNLENFT SGSPFLCMDL SYITALLKDG FGFADSTVLQ
410 420
LTKKVNNIET GWALGATFHL LQSLGISH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471061 Genomic DNA Translation: EAW81154.1 CH471061 Genomic DNA Translation: EAW81155.1 CH471061 Genomic DNA Translation: EAW81156.1 |
RefSeqi | NP_001240.1, NM_001249.3 NP_001308914.1, NM_001321985.1 NP_001308915.1, NM_001321986.1 NP_001308916.1, NM_001321987.1 NP_001308917.1, NM_001321988.1 XP_005268281.1, XM_005268224.3 XP_016877302.1, XM_017021813.1 |
Genome annotation databases
GeneIDi | 957 |
KEGGi | hsa:957 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471061 Genomic DNA Translation: EAW81154.1 CH471061 Genomic DNA Translation: EAW81155.1 CH471061 Genomic DNA Translation: EAW81156.1 |
RefSeqi | NP_001240.1, NM_001249.3 NP_001308914.1, NM_001321985.1 NP_001308915.1, NM_001321986.1 NP_001308916.1, NM_001321987.1 NP_001308917.1, NM_001321988.1 XP_005268281.1, XM_005268224.3 XP_016877302.1, XM_017021813.1 |
3D structure databases
SMRi | A0A024R6D3 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 148, 236 antibodies |
Genome annotation databases
GeneIDi | 957 |
KEGGi | hsa:957 |
Organism-specific databases
CTDi | 957 |
VEuPathDBi | HostDB:ENSG00000187097.12 |
Phylogenomic databases
HOGENOMi | CLU_010246_0_2_1 |
OMAi | YEMPIDR |
OrthoDBi | 1337265at2759 |
Miscellaneous databases
BioGRID-ORCSi | 957, 5 hits in 876 CRISPR screens |
ChiTaRSi | ENTPD5, human |
GenomeRNAii | 957 |
Gene expression databases
Bgeei | ENSG00000187097, Expressed in colon and 207 other tissues |
ExpressionAtlasi | A0A024R6D3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000407, GDA1_CD39_NTPase |
PANTHERi | PTHR11782, PTHR11782, 1 hit |
Pfami | View protein in Pfam PF01150, GDA1_CD39, 1 hit |
PROSITEi | View protein in PROSITE PS01238, GDA1_CD39_NTPASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R6D3_HUMAN | |
Accessioni | A0A024R6D3Primary (citable) accession number: A0A024R6D3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 10, 2021 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |