UniProtKB - A0A024R6C9 (A0A024R6C9_HUMAN)
Protein
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Gene
DLST
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- (R)-N6-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N6-(S8-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoAARBA annotationEC:2.3.1.61ARBA annotationThis reaction proceeds in the backwardARBA annotation direction.
Cofactori
(R)-lipoateARBA annotation
: L-lysine degradation via saccharopine pathway Pathwayi
This protein is involved in step 6 of the subpathway that synthesizes glutaryl-CoA from L-lysine.ARBA annotationProteins known to be involved in the 6 steps of the subpathway in this organism are:
- Lysine ketoglutarate reductase (AASS), Alpha-aminoadipic semialdehyde synthase, mitochondrial (AASS), Lysine ketoglutarate reductase (AASS)
- Lysine ketoglutarate reductase (AASS), Alpha-aminoadipic semialdehyde synthase, mitochondrial (AASS), Lysine ketoglutarate reductase (AASS)
- no protein annotated in this organism
- Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (AADAT)
- no protein annotated in this organism
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST), Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST), Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST), Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (E2k)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glutaryl-CoA from L-lysine, the pathway L-lysine degradation via saccharopine pathway and in Amino-acid degradation.
Pathwayi: tricarboxylic acid cycle
This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.ARBA annotationView all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.
GO - Molecular functioni
- dihydrolipoyllysine-residue succinyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- L-lysine catabolic process to acetyl-CoA via saccharopine Source: UniProtKB-UniPathway
- tricarboxylic acid cycle Source: UniProtKB-UniPathway
Keywordsi
Molecular function | TransferaseImportedARBA annotation |
Biological process | Tricarboxylic acid cycleARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00223 UPA00868;UER00840 |
Names & Taxonomyi
Protein namesi | Recommended name: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrialARBA annotation (EC:2.3.1.61ARBA annotation)Alternative name(s): E2KARBA annotation |
Gene namesi | Name:DLSTImported ORF Names:hCG_22359Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000119689.14 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix ARBA annotation
Cytoskeleton
- centriolar satellite Source: HPA
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- oxoglutarate dehydrogenase complex Source: InterPro
Keywords - Cellular componenti
MitochondrionARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000119689, Expressed in heart and 239 other tissues |
ExpressionAtlasi | A0A024R6C9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 70 – 144 | Lipoyl-bindingInterPro annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 152 – 225 | DisorderedSequence analysisAdd BLAST | 74 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 169 – 197 | Pro-richSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the 2-oxoacid dehydrogenase family.ARBA annotation
Keywords - Domaini
LipoylARBA annotation, Transit peptideARBA annotationPhylogenomic databases
HOGENOMi | CLU_016733_0_0_1 |
OMAi | MKVPSPG |
OrthoDBi | 850255at2759 |
PhylomeDBi | A0A024R6C9 |
Family and domain databases
Gene3Di | 3.30.559.10, 1 hit |
InterProi | View protein in InterPro IPR003016, 2-oxoA_DH_lipoyl-BS IPR001078, 2-oxoacid_DH_actylTfrase IPR000089, Biotin_lipoyl IPR023213, CAT-like_dom_sf IPR011053, Single_hybrid_motif IPR006255, SucB |
Pfami | View protein in Pfam PF00198, 2-oxoacid_dh, 1 hit PF00364, Biotin_lipoyl, 1 hit |
SUPFAMi | SSF51230, SSF51230, 1 hit |
TIGRFAMsi | TIGR01347, sucB, 1 hit |
PROSITEi | View protein in PROSITE PS50968, BIOTINYL_LIPOYL, 1 hit PS00189, LIPOYL, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R6C9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSRSRCVSR AFSRSLSAFQ KGNCPLGRRS LPGVSLCQGP GYPNSRKVVI
60 70 80 90 100
NNSVFSVRFF RTTAVCKDDL VTVKTPAFAE SVTEGDVRWE KAVGDTVAED
110 120 130 140 150
EVVCEIETDK TSVQVPSPAN GVIEALLVPD GGKVEGGTPL FTLRKTGAAP
160 170 180 190 200
AKAKPAEAPA AAAPKAEPTA AAVPPPAAPI PTQMPPVPSP SQPPSGKPVS
210 220 230 240 250
AVKPTVAPPL AEPGAGKGLR SEHREKMNRM RQRIAQRLKE AQNTCAMLTT
260 270 280 290 300
FNEIDMSNIQ EMRARHKEAF LKKHNLKLGF MSAFVKASAF ALQEQPVVNA
310 320 330 340 350
VIDDTTKEVV YRDYIDISVA VATPRGLVVP VIRNVEAMNF ADIERTITEL
360 370 380 390 400
GEKARKNELA IEDMDGGTFT ISNGGVFGSL FGTPIINPPQ SAILGMHGIF
410 420 430 440 450
DRPVAIGGKV EVRPMMYVAL TYDHRLIDGR EAVTFLRKIK AAVEDPRVLL
LDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471061 Genomic DNA Translation: EAW81202.1 |
RefSeqi | NP_001924.2, NM_001933.4 |
Genome annotation databases
GeneIDi | 1743 |
KEGGi | hsa:1743 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471061 Genomic DNA Translation: EAW81202.1 |
RefSeqi | NP_001924.2, NM_001933.4 |
3D structure databases
SMRi | A0A024R6C9 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 45, 200 antibodies |
DNASUi | 1743 |
Genome annotation databases
GeneIDi | 1743 |
KEGGi | hsa:1743 |
Organism-specific databases
CTDi | 1743 |
VEuPathDBi | HostDB:ENSG00000119689.14 |
Phylogenomic databases
HOGENOMi | CLU_016733_0_0_1 |
OMAi | MKVPSPG |
OrthoDBi | 850255at2759 |
PhylomeDBi | A0A024R6C9 |
Enzyme and pathway databases
UniPathwayi | UPA00223 UPA00868;UER00840 |
Miscellaneous databases
BioGRID-ORCSi | 1743, 202 hits in 999 CRISPR screens |
ChiTaRSi | DLST, human |
GenomeRNAii | 1743 |
Gene expression databases
Bgeei | ENSG00000119689, Expressed in heart and 239 other tissues |
ExpressionAtlasi | A0A024R6C9, baseline and differential |
Family and domain databases
Gene3Di | 3.30.559.10, 1 hit |
InterProi | View protein in InterPro IPR003016, 2-oxoA_DH_lipoyl-BS IPR001078, 2-oxoacid_DH_actylTfrase IPR000089, Biotin_lipoyl IPR023213, CAT-like_dom_sf IPR011053, Single_hybrid_motif IPR006255, SucB |
Pfami | View protein in Pfam PF00198, 2-oxoacid_dh, 1 hit PF00364, Biotin_lipoyl, 1 hit |
SUPFAMi | SSF51230, SSF51230, 1 hit |
TIGRFAMsi | TIGR01347, sucB, 1 hit |
PROSITEi | View protein in PROSITE PS50968, BIOTINYL_LIPOYL, 1 hit PS00189, LIPOYL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R6C9_HUMAN | |
Accessioni | A0A024R6C9Primary (citable) accession number: A0A024R6C9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | April 7, 2021 | |
This is version 42 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |