UniProtKB - A0A024R6B9 (A0A024R6B9_HUMAN)
Protein
Submitted name:
ATP-binding cassette, sub-family D (ALD), member 4, isoform CRA_b
Gene
ABCD4
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 421 – 428 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-UniRule
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: Ensembl
Keywordsi
Biological process | TransportARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationImportedARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: ATP-binding cassette, sub-family D (ALD), member 4, isoform CRA_bImported |
Gene namesi | Name:ABCD4Imported ORF Names:hCG_21713Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000119688.20 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 39 – 58 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 78 – 96 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 182 – 201 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 268 – 294 | HelicalSequence analysisAdd BLAST | 27 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000119688, Expressed in left lobe of thyroid gland and 218 other tissues |
ExpressionAtlasi | A0A024R6B9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 311 | ABC transmembrane type-1InterPro annotationAdd BLAST | 272 | |
Domaini | 389 – 603 | ABC transporterInterPro annotationAdd BLAST | 215 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_007587_7_0_1 |
OMAi | RFWISAR |
OrthoDBi | 309052at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF06472, ABC_membrane_2, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R6B9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVAGPAPGA GARPRLDLQF LQRFLQILKV LFPSWSSQNA LMFLTLLCLT
60 70 80 90 100
LLEQFVIYQV GLIPSQYYGV LGNKDLEGFK TLTFLAVMLI VLNSTLKSFD
110 120 130 140 150
QFTCNLLYVS WRKDLTEHLH RLYFRGRAYY TLNVLRDDID NPDQRISQDV
160 170 180 190 200
ERFCRQLSSM ASKLIISPFT LVYYTYQCFQ STGWLGPVSI FGYFILGTVV
210 220 230 240 250
NKTLMGPIVM KLVHQEKLEG DFRFKHMQIR VNAEPAAFYR AGHVEHMRTD
260 270 280 290 300
RRLQRLLQTQ RELMSKELWL YIGINTFDYL GSILSYVVIA IPIFSGVYGD
310 320 330 340 350
LSPAELSTLV SKNAFVCIYL ISCFTQLIDL STTLSDVAGY THRIGQLRET
360 370 380 390 400
LLDMSLKSQD CEILGESEWG LDTPPGWPAA EPADTAFLLE RVSISAPSSD
410 420 430 440 450
KPLIKDLSLK ISEGQSLLIT GNTGTGKTSL LRVLGGLWTS TRGSVQMLTD
460 470 480 490 500
FGPHGVLFLP QKPFFTDGTL REQVIYPLKE VYPDSGSADD ERILRFLELA
510 520 530 540 550
GLSNLVARTE GLDQQVDWNW YDVLSPGEMQ RLSFARLFYL QPKYAVLDEA
560 570 580 590 600
TSALTEEVES ELYRIGQQLG MTFISVGHRQ SLEKFHSLVL KLCGGGRWEL
MRIKVE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471061 Genomic DNA Translation: EAW81167.1 CH471061 Genomic DNA Translation: EAW81172.1 |
RefSeqi | NP_005041.1, NM_005050.3 |
Genome annotation databases
GeneIDi | 5826 |
KEGGi | hsa:5826 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471061 Genomic DNA Translation: EAW81167.1 CH471061 Genomic DNA Translation: EAW81172.1 |
RefSeqi | NP_005041.1, NM_005050.3 |
3D structure databases
SMRi | A0A024R6B9 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 184, 226 antibodies |
Genome annotation databases
GeneIDi | 5826 |
KEGGi | hsa:5826 |
Organism-specific databases
CTDi | 5826 |
VEuPathDBi | HostDB:ENSG00000119688.20 |
Phylogenomic databases
HOGENOMi | CLU_007587_7_0_1 |
OMAi | RFWISAR |
OrthoDBi | 309052at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5826, 20 hits in 873 CRISPR screens |
ChiTaRSi | ABCD4, human |
GenomeRNAii | 5826 |
Gene expression databases
Bgeei | ENSG00000119688, Expressed in left lobe of thyroid gland and 218 other tissues |
ExpressionAtlasi | A0A024R6B9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF06472, ABC_membrane_2, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R6B9_HUMAN | |
Accessioni | A0A024R6B9Primary (citable) accession number: A0A024R6B9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 10, 2021 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |