SMAD3

Functionⁱ

GO - Molecular functionⁱ

beta-catenin binding Source: Ensembl
chromatin DNA binding Source: Ensembl
collagen binding Source: Ensembl
DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
enzyme binding Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
SMAD binding Source: Ensembl
transcription factor binding Source: Ensembl

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
adrenal gland development Source: Ensembl
developmental growth Source: Ensembl
embryonic cranial skeleton morphogenesis Source: Ensembl
embryonic foregut morphogenesis Source: Ensembl
embryonic pattern specification Source: Ensembl
endoderm development Source: Ensembl
heart looping Source: Ensembl
immune system development Source: Ensembl
in utero embryonic development Source: Ensembl
lens fiber cell differentiation Source: Ensembl
liver development Source: Ensembl
mesoderm formation Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of cardiac muscle hypertrophy in response to stress Source: Ensembl
negative regulation of inflammatory response Source: Ensembl
negative regulation of lung blood pressure Source: Ensembl
negative regulation of osteoblast differentiation Source: Ensembl
negative regulation of osteoblast proliferation Source: Ensembl
negative regulation of protein catabolic process Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
negative regulation of wound healing Source: Ensembl
osteoblast development Source: Ensembl
paraxial mesoderm morphogenesis Source: Ensembl
pericardium development Source: Ensembl
positive regulation of alkaline phosphatase activity Source: Ensembl
positive regulation of bone mineralization Source: Ensembl
positive regulation of canonical Wnt signaling pathway Source: Ensembl
positive regulation of cell migration Source: Ensembl
positive regulation of chondrocyte differentiation Source: Ensembl
positive regulation of focal adhesion assembly Source: Ensembl
positive regulation of interleukin-1 beta production Source: Ensembl
positive regulation of nitric oxide biosynthetic process Source: Ensembl
positive regulation of positive chemotaxis Source: Ensembl
positive regulation of stress fiber assembly Source: Ensembl
positive regulation of transforming growth factor beta3 production Source: Ensembl
protein stabilization Source: Ensembl
regulation of binding Source: Ensembl
regulation of epithelial cell proliferation Source: Ensembl
regulation of immune response Source: Ensembl
regulation of striated muscle tissue development Source: Ensembl
regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
signal transduction involved in regulation of gene expression Source: Ensembl
SMAD protein complex assembly Source: Ensembl
SMAD protein signal transduction Source: Ensembl
somitogenesis Source: Ensembl
T cell activation Source: Ensembl
thyroid gland development Source: Ensembl
transdifferentiation Source: Ensembl
transforming growth factor beta receptor signaling pathway Source: Ensembl
ureteric bud development Source: Ensembl

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotation
Biological process	Transcription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mothers against decapentaplegic homologUniRule annotation Short name: MAD homologUniRule annotation Short name: Mothers against DPP homologUniRule annotation Alternative name(s): SMAD family memberUniRule annotation
Gene namesⁱ	Name:SMAD3Imported ORF Names:hCG_22521Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000166949 Expressed in amniotic fluid and 228 other tissues
ExpressionAtlasⁱ	A0A024R5Z3 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

beta-catenin binding Source: Ensembl
enzyme binding Source: Ensembl
SMAD binding Source: Ensembl
transcription factor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	A0A024R5Z3
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	10 – 136	MH1InterPro annotationAdd BLAST		127
Domainⁱ	232 – 425	MH2InterPro annotationAdd BLAST		194

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	165 – 208	DisorderedSequence analysisAdd BLAST		44

Sequence similaritiesⁱ

Belongs to the dwarfin/SMAD family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3701 Eukaryota ENOG410XQKU LUCA
KEGG Orthology (KO) More...KOⁱ	K23605
OMAⁱ	RHTEIPS
Database of Orthologous Groups More...OrthoDBⁱ	608001at2759

Family and domain databases

Gene3Dⁱ	2.60.200.10, 1 hit 3.90.520.10, 1 hit
InterProⁱ	View protein in InterPro IPR013790 Dwarfin IPR003619 MAD_homology1_Dwarfin-type IPR013019 MAD_homology_MH1 IPR017855 SMAD-like_dom_sf IPR001132 SMAD_dom_Dwarfin-type IPR008984 SMAD_FHA_dom_sf IPR036578 SMAD_MH1_sf
PANTHERⁱ	PTHR13703 PTHR13703, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03165 MH1, 1 hit PF03166 MH2, 1 hit
SMARTⁱ	View protein in SMART SM00523 DWA, 1 hit SM00524 DWB, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit SSF56366 SSF56366, 1 hit
PROSITEⁱ	View protein in PROSITE PS51075 MH1, 1 hit PS51076 MH2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A024R5Z3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE 
        60         70         80         90        100
LEKAITTQNV NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH 
       110        120        130        140        150
HELRAMELCE FAFNMKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF 
       160        170        180        190        200
PPLDDYSHSI PENTNFPAGI EPQSNIPETP PPGYLSEDGE TSDHQMNHSM 
       210        220        230        240        250
DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL NQRVGETFHA 
       260        270        280        290        300
SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG 
       310        320        330        340        350
GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA 
       360        370        380        390        400
LLAQSVNQGF EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL 
       410        420 
NGPLQWLDKV LTQMGSPSIR CSSVS

Length:425

Mass (Da):48,081

Last modified:July 9, 2014 - v1

Checksum:ⁱ46DF5E8B371321AC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471082 Genomic DNA Translation: EAW77789.1 CH471082 Genomic DNA Translation: EAW77790.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005893.1, NM_005902.3

Genome annotation databases

GeneIDⁱ	4088
KEGGⁱ	hsa:4088

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A024R5Z3	Mothers against decapentaplegic homolog 3	)	HUMAN		425	UniRef100_P84022
Mothers against decapentaplegic homolog 3		MOUSE		425
Mothers against decapentaplegic homolog 3		PIG		425
Mothers against decapentaplegic homolog 3		RAT		425
Mothers against decapentaplegic homolog		GORGO		356
+62

Protein	Similar proteins		Species	Score	Length	Source
A0A024R5Z3	Mothers against decapentaplegic homolog 3	)	HUMAN		425	UniRef90_P84022
Mothers against decapentaplegic homolog 3		MOUSE		425
Mothers against decapentaplegic homolog 3		PIG		425
Mothers against decapentaplegic homolog 3		RAT		425
Mothers against decapentaplegic homolog		GORGO		356
+88

Protein	Similar proteins		Species	Score	Length	Source
A0A024R5Z3	Mothers against decapentaplegic homolog 3	)	HUMAN		425	UniRef50_P84022
Mothers against decapentaplegic homolog 3		MOUSE		425
Mothers against decapentaplegic homolog 3		PIG		425
Mothers against decapentaplegic homolog 3		RAT		425
Mothers against decapentaplegic homolog		GORGO		356
+126

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471082 Genomic DNA Translation: EAW77789.1 CH471082 Genomic DNA Translation: EAW77790.1
RefSeqⁱ	NP_005893.1, NM_005902.3

3D structure databases

SMRⁱ	A0A024R5Z3
ModBaseⁱ	Search...

Genome annotation databases

GeneIDⁱ	4088
KEGGⁱ	hsa:4088

Organism-specific databases

CTDⁱ	4088

CTDⁱ

4088

Phylogenomic databases

eggNOGⁱ	KOG3701 Eukaryota ENOG410XQKU LUCA
KOⁱ	K23605
OMAⁱ	RHTEIPS
OrthoDBⁱ	608001at2759

Miscellaneous databases

ChiTaRSⁱ	SMAD3 human
GenomeRNAiⁱ	4088

Gene expression databases

Bgeeⁱ	ENSG00000166949 Expressed in amniotic fluid and 228 other tissues
ExpressionAtlasⁱ	A0A024R5Z3 baseline and differential

Family and domain databases

Gene3Dⁱ	2.60.200.10, 1 hit 3.90.520.10, 1 hit
InterProⁱ	View protein in InterPro IPR013790 Dwarfin IPR003619 MAD_homology1_Dwarfin-type IPR013019 MAD_homology_MH1 IPR017855 SMAD-like_dom_sf IPR001132 SMAD_dom_Dwarfin-type IPR008984 SMAD_FHA_dom_sf IPR036578 SMAD_MH1_sf
PANTHERⁱ	PTHR13703 PTHR13703, 1 hit
Pfamⁱ	View protein in Pfam PF03165 MH1, 1 hit PF03166 MH2, 1 hit
SMARTⁱ	View protein in SMART SM00523 DWA, 1 hit SM00524 DWB, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit SSF56366 SSF56366, 1 hit
PROSITEⁱ	View protein in PROSITE PS51075 MH1, 1 hit PS51076 MH2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A024R5Z3_HUMAN
Accessionⁱ	A0A024R5Z3Primary (citable) accession number: A0A024R5Z3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 9, 2014
	Last sequence update:	July 9, 2014
	Last modified:	February 26, 2020
	This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A0A024R5Z3 (A0A024R5Z3_HUMAN)

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Mothers against decapentaplegic homolog

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

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Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ