UniProtKB - A0A024R5Z3 (A0A024R5Z3_HUMAN)
Protein
Mothers against decapentaplegic homolog
Gene
SMAD3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- beta-catenin binding Source: Ensembl
- chromatin DNA binding Source: Ensembl
- collagen binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- enzyme binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl
- SMAD binding Source: Ensembl
- transcription factor binding Source: Ensembl
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
- adrenal gland development Source: Ensembl
- developmental growth Source: Ensembl
- embryonic cranial skeleton morphogenesis Source: Ensembl
- embryonic foregut morphogenesis Source: Ensembl
- embryonic pattern specification Source: Ensembl
- endoderm development Source: Ensembl
- heart looping Source: Ensembl
- immune system development Source: Ensembl
- in utero embryonic development Source: Ensembl
- lens fiber cell differentiation Source: Ensembl
- liver development Source: Ensembl
- mesoderm formation Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of cardiac muscle hypertrophy in response to stress Source: Ensembl
- negative regulation of inflammatory response Source: Ensembl
- negative regulation of lung blood pressure Source: Ensembl
- negative regulation of osteoblast differentiation Source: Ensembl
- negative regulation of osteoblast proliferation Source: Ensembl
- negative regulation of protein catabolic process Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- negative regulation of wound healing Source: Ensembl
- osteoblast development Source: Ensembl
- paraxial mesoderm morphogenesis Source: Ensembl
- pericardium development Source: Ensembl
- positive regulation of alkaline phosphatase activity Source: Ensembl
- positive regulation of bone mineralization Source: Ensembl
- positive regulation of canonical Wnt signaling pathway Source: Ensembl
- positive regulation of cell migration Source: Ensembl
- positive regulation of chondrocyte differentiation Source: Ensembl
- positive regulation of focal adhesion assembly Source: Ensembl
- positive regulation of interleukin-1 beta production Source: Ensembl
- positive regulation of nitric oxide biosynthetic process Source: Ensembl
- positive regulation of positive chemotaxis Source: Ensembl
- positive regulation of stress fiber assembly Source: Ensembl
- positive regulation of transforming growth factor beta3 production Source: Ensembl
- protein stabilization Source: Ensembl
- regulation of binding Source: Ensembl
- regulation of epithelial cell proliferation Source: Ensembl
- regulation of immune response Source: Ensembl
- regulation of striated muscle tissue development Source: Ensembl
- regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- signal transduction involved in regulation of gene expression Source: Ensembl
- SMAD protein complex assembly Source: Ensembl
- SMAD protein signal transduction Source: Ensembl
- somitogenesis Source: Ensembl
- T cell activation Source: Ensembl
- thyroid gland development Source: Ensembl
- transdifferentiation Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: Ensembl
- ureteric bud development Source: Ensembl
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Mothers against decapentaplegic homologUniRule annotationShort name: MAD homologUniRule annotation Short name: Mothers against DPP homologUniRule annotation Alternative name(s): SMAD family memberUniRule annotation |
Gene namesi | Name:SMAD3Imported ORF Names:hCG_22521Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000166949.15 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000166949, Expressed in amniotic fluid and 241 other tissues |
ExpressionAtlasi | A0A024R5Z3, baseline and differential |
Interactioni
GO - Molecular functioni
- beta-catenin binding Source: Ensembl
- enzyme binding Source: Ensembl
- SMAD binding Source: Ensembl
- transcription factor binding Source: Ensembl
Chemistry databases
BindingDBi | A0A024R5Z3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 136 | MH1InterPro annotationAdd BLAST | 127 | |
Domaini | 232 – 425 | MH2InterPro annotationAdd BLAST | 194 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 165 – 208 | DisorderedSequence analysisAdd BLAST | 44 |
Sequence similaritiesi
Phylogenomic databases
OMAi | NPVSPAH |
OrthoDBi | 608001at2759 |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit 3.90.520.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 1 hit |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R5Z3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE
60 70 80 90 100
LEKAITTQNV NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH
110 120 130 140 150
HELRAMELCE FAFNMKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF
160 170 180 190 200
PPLDDYSHSI PENTNFPAGI EPQSNIPETP PPGYLSEDGE TSDHQMNHSM
210 220 230 240 250
DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL NQRVGETFHA
260 270 280 290 300
SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG
310 320 330 340 350
GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA
360 370 380 390 400
LLAQSVNQGF EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL
410 420
NGPLQWLDKV LTQMGSPSIR CSSVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471082 Genomic DNA Translation: EAW77789.1 CH471082 Genomic DNA Translation: EAW77790.1 |
RefSeqi | NP_005893.1, NM_005902.3 |
Genome annotation databases
GeneIDi | 4088 |
KEGGi | hsa:4088 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471082 Genomic DNA Translation: EAW77789.1 CH471082 Genomic DNA Translation: EAW77790.1 |
RefSeqi | NP_005893.1, NM_005902.3 |
3D structure databases
SMRi | A0A024R5Z3 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024R5Z3 |
Protocols and materials databases
Antibodypediai | 26224, 2302 antibodies |
DNASUi | 4088 |
Genome annotation databases
GeneIDi | 4088 |
KEGGi | hsa:4088 |
Organism-specific databases
CTDi | 4088 |
VEuPathDBi | HostDB:ENSG00000166949.15 |
Phylogenomic databases
OMAi | NPVSPAH |
OrthoDBi | 608001at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4088, 9 hits in 1020 CRISPR screens |
ChiTaRSi | SMAD3, human |
GenomeRNAii | 4088 |
Gene expression databases
Bgeei | ENSG00000166949, Expressed in amniotic fluid and 241 other tissues |
ExpressionAtlasi | A0A024R5Z3, baseline and differential |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit 3.90.520.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 1 hit |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R5Z3_HUMAN | |
Accessioni | A0A024R5Z3Primary (citable) accession number: A0A024R5Z3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | April 7, 2021 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |