UniProtKB - A0A024R5Z0 (A0A024R5Z0_HUMAN)
Protein
Submitted name:
Transcription factor 12 (HTF4, helix-loop-helix transcription factors 4), isoform CRA_b
Gene
TCF12
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cAMP response element binding Source: Ensembl
- E-box binding Source: Ensembl
- HMG box domain binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
GO - Biological processi
- positive regulation of neuron differentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor 12 (HTF4, helix-loop-helix transcription factors 4), isoform CRA_bImported |
Gene namesi | Name:TCF12Imported ORF Names:hCG_40686Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000140262.17 |
Subcellular locationi
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
- transcription regulator complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000140262, Expressed in corpus callosum and 245 other tissues |
ExpressionAtlasi | A0A024R5Z0, baseline and differential |
Interactioni
GO - Molecular functioni
- HMG box domain binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 601 – 654 | BHLHInterPro annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 122 | DisorderedSequence analysisAdd BLAST | 98 | |
Regioni | 140 – 219 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 281 – 313 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 349 – 392 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 492 – 604 | DisorderedSequence analysisAdd BLAST | 113 | |
Regioni | 675 – 706 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 29 – 80 | PolarSequence analysisAdd BLAST | 52 | |
Compositional biasi | 99 – 122 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 140 – 167 | PolarSequence analysisAdd BLAST | 28 | |
Compositional biasi | 492 – 541 | PolarSequence analysisAdd BLAST | 50 | |
Compositional biasi | 542 – 574 | PolyampholyteSequence analysisAdd BLAST | 33 | |
Compositional biasi | 581 – 604 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 692 – 706 | PolarSequence analysisAdd BLAST | 15 |
Phylogenomic databases
HOGENOMi | CLU_021099_2_0_1 |
OMAi | RYADEDC |
OrthoDBi | 571132at2759 |
PhylomeDBi | A0A024R5Z0 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R5Z0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG
60 70 80 90 100
IDERGGTTSW GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGAHEGLSPT
110 120 130 140 150
PFMNSNLMGK TSERGSFSLY SRDTGLPGCQ SSLLRQDLGL GSPAQLSSSG
160 170 180 190 200
KPGTAYYSFS ATSSRRRPLH DSAALDPLQA KKVRKVPPGL PSSVYAPSPN
210 220 230 240 250
SDDFNRESPS YPSPKPPTSM FASTFFMQDG THNSSDLWSS SNGMSQPGFG
260 270 280 290 300
GILGTSTSHM SQSSSYGNLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG
310 320 330 340 350
STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD
360 370 380 390 400
HTSSSFPSNP STPVGSPSPL TGTSQWPRPG GQAPSSPSYE NSLHSLKNRV
410 420 430 440 450
EQQLHEHLQD AMSFLKDVCE QSRMEDRLDR LDDAIHVLRN HAVGPSTSLP
460 470 480 490 500
AGHSDIHSLL GPSHNAPIGS LNSNYGGSSL VASSRSASMV GTHREDSVSL
510 520 530 540 550
NGNHSVLSST VTTSSTDLNH KTQENYRGGL QSQSGTVVTT EIKTENKEKD
560 570 580 590 600
ENLHEPPSSD DMKSDDESSQ KDIKVSSRGR TSSTNEDEDL NPEQKIEREK
610 620 630 640 650
ERRMANNARE RLRVRDINEA FKELGRMCQL HLKSEKPQTK LLILHQAVAV
660 670 680 690 700
ILSLEQQVRE RNLNPKAACL KRREEEKVSA VSAEPPTTLP GTHPGLSETT
NPMGHM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471082 Genomic DNA Translation: EAW77514.1 |
RefSeqi | NP_001309080.1, NM_001322151.1 NP_001309088.1, NM_001322159.1 NP_001309091.1, NM_001322162.1 NP_996919.1, NM_207036.1 NP_996920.1, NM_207037.1 |
Genome annotation databases
GeneIDi | 6938 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471082 Genomic DNA Translation: EAW77514.1 |
RefSeqi | NP_001309080.1, NM_001322151.1 NP_001309088.1, NM_001322159.1 NP_001309091.1, NM_001322162.1 NP_996919.1, NM_207036.1 NP_996920.1, NM_207037.1 |
3D structure databases
SMRi | A0A024R5Z0 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 913, 372 antibodies |
Genome annotation databases
GeneIDi | 6938 |
Organism-specific databases
CTDi | 6938 |
EuPathDBi | HostDB:ENSG00000140262.17 |
Phylogenomic databases
HOGENOMi | CLU_021099_2_0_1 |
OMAi | RYADEDC |
OrthoDBi | 571132at2759 |
PhylomeDBi | A0A024R5Z0 |
Miscellaneous databases
BioGRID-ORCSi | 6938, 13 hits in 866 CRISPR screens |
ChiTaRSi | TCF12, human |
GenomeRNAii | 6938 |
Gene expression databases
Bgeei | ENSG00000140262, Expressed in corpus callosum and 245 other tissues |
ExpressionAtlasi | A0A024R5Z0, baseline and differential |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R5Z0_HUMAN | |
Accessioni | A0A024R5Z0Primary (citable) accession number: A0A024R5Z0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |