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UniProtKB - A0A024R5Y9 (A0A024R5Y9_HUMAN)

Entry version 47 (02 Dec 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Zinc finger protein 588, isoform CRA_d

Gene

ZNF588

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein 588, isoform CRA_dImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF588Imported
ORF Names:hCG_41164Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000196247.11

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196247, Expressed in lymph node and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A024R5Y9, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A024R5Y9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 131C2H2-typeInterPro annotationAdd BLAST28
Domaini132 – 159C2H2-typeInterPro annotationAdd BLAST28
Domaini160 – 187C2H2-typeInterPro annotationAdd BLAST28
Domaini188 – 215C2H2-typeInterPro annotationAdd BLAST28
Domaini216 – 243C2H2-typeInterPro annotationAdd BLAST28
Domaini244 – 271C2H2-typeInterPro annotationAdd BLAST28
Domaini272 – 299C2H2-typeInterPro annotationAdd BLAST28
Domaini300 – 327C2H2-typeInterPro annotationAdd BLAST28
Domaini328 – 355C2H2-typeInterPro annotationAdd BLAST28
Domaini356 – 383C2H2-typeInterPro annotationAdd BLAST28
Domaini384 – 411C2H2-typeInterPro annotationAdd BLAST28
Domaini412 – 439C2H2-typeInterPro annotationAdd BLAST28
Domaini440 – 467C2H2-typeInterPro annotationAdd BLAST28
Domaini468 – 495C2H2-typeInterPro annotationAdd BLAST28
Domaini496 – 523C2H2-typeInterPro annotationAdd BLAST28
Domaini524 – 551C2H2-typeInterPro annotationAdd BLAST28
Domaini552 – 579C2H2-typeInterPro annotationAdd BLAST28
Domaini580 – 607C2H2-typeInterPro annotationAdd BLAST28
Domaini608 – 635C2H2-typeInterPro annotationAdd BLAST28
Domaini636 – 663C2H2-typeInterPro annotationAdd BLAST28
Domaini664 – 691C2H2-typeInterPro annotationAdd BLAST28
Domaini692 – 719C2H2-typeInterPro annotationAdd BLAST28
Domaini720 – 747C2H2-typeInterPro annotationAdd BLAST28
Domaini748 – 775C2H2-typeInterPro annotationAdd BLAST28

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 22 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 13 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 16 hits
PS50157, ZINC_FINGER_C2H2_2, 24 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R5Y9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAKPPVMSF HFAQDLWPEQ NIKDSFQKVT LRRYGKCEYE NLQLRKGCKH 
        60         70         80         90        100
VDECTGHKGG HNTVNQCLTA TPSKIFQCNK YVKVFDKFSN SNRYKRRHTG 
       110        120        130        140        150
NKHFKCKECS KSFCVLSQLT QHRRIHTRVN SYKCEECGKA FNWFSTLTKH 
       160        170        180        190        200
KRIHTGEKPY KCEECGKAFN QSSQLTRHKI IHTEEKPNKC EECGKAFKQA 
       210        220        230        240        250
SHLTIHKIIH TGEKPYKYEE CGKVFSQSSH LTTQKILHTG ENLYKCKECG 
       260        270        280        290        300
KAFNLFSNLT NHKRIHAGEK PYKCKECGRA FNISSNLNKQ EKIHTGGKLN 
       310        320        330        340        350
KCEECDKAFN RSLKLTAHKK ILMEEKPYKC EECGKVFNQF STLTRHKIIH 
       360        370        380        390        400
TGEKPYKCKE CGKAFNQSSN LTEHKKIHTA EKSYKCEECG KAFNQHSNLI 
       410        420        430        440        450
NHRKIYSGEK PYKCEECGKA FNRSSTLTRH KKIHTGEKPY KCEECDRAFS 
       460        470        480        490        500
QSSNLTEHKK IHTGEKPYKC EECGKAFNRF STLTKHKRIH TGEKPYKCEE 
       510        520        530        540        550
CGKAFNQSYQ LTRHKIVHTK EKLNKCEEFG KAFKQSSHRT IHKIIHTGEK 
       560        570        580        590        600
PYKCEEHGKV FNQSSNLTTQ KIIHTGENLY KFEEHGKAFN LFSNITNHKI 
       610        620        630        640        650
IYTGEKPHKC EECGKAYNRF SNLTIHKRIH TGEKPYQCAE CGKAFNCSST 
       660        670        680        690        700
LNRHKIIHTG EKPYKCKECG KAFNLSSTLT AHKKIHTGEK PYKCEECGKA 
       710        720        730        740        750
FNQSSNLTTH KKIHTSEKPY KCEECGKSFN QFSSLNIHKI IHTGEKPYKC 
       760        770        780 
GDYGRAFNLS SNLTTHKKIH TGEKPYKCEY GKT
Length:783
Mass (Da):90,673
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84882575525DC34C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH471204 Genomic DNA Translation: EAW77976.1
CH471204 Genomic DNA Translation: EAW77977.1

NCBI Reference Sequences

More...RefSeqi		NP_001013768.1, NM_001013746.2
NP_057304.1, NM_016220.4
XP_016867772.1, XM_017012283.1
XP_016867773.1, XM_017012284.1
XP_016867774.1, XM_017012285.1
XP_016867775.1, XM_017012286.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51427

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51427

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471204 Genomic DNA Translation: EAW77976.1
CH471204 Genomic DNA Translation: EAW77977.1
RefSeqiNP_001013768.1, NM_001013746.2
NP_057304.1, NM_016220.4
XP_016867772.1, XM_017012283.1
XP_016867773.1, XM_017012284.1
XP_016867774.1, XM_017012285.1
XP_016867775.1, XM_017012286.1

3D structure databases

SMRiA0A024R5Y9
ModBaseiSearch...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		55871, 3 antibodies

Genome annotation databases

GeneIDi51427
KEGGihsa:51427

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51427
EuPathDBiHostDB:ENSG00000196247.11

Phylogenomic databases

OrthoDBi1318335at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51427, 6 hits in 837 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF107, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51427

Gene expression databases

BgeeiENSG00000196247, Expressed in lymph node and 212 other tissues
ExpressionAtlasiA0A024R5Y9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 16 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 22 hits
SUPFAMiSSF57667, SSF57667, 13 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 16 hits
PS50157, ZINC_FINGER_C2H2_2, 24 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R5Y9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R5Y9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: December 2, 2020
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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