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UniProtKB - A0A024R5Y1 (A0A024R5Y1_HUMAN)
Protein
Maspardin
Gene
SPG21
Organism
Homo sapiens (Human)
Status
Functioni
May play a role as a negative regulatory factor in CD4-dependent T-cell activation.
ARBA annotationProtein family/group databases
ESTHERi | human-SPG21, Maspardin-ACP33-SPG21_like |
Names & Taxonomyi
Protein namesi | Recommended name: MaspardinARBA annotation |
Gene namesi | Name:SPG21Imported ORF Names:hCG_1786858Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000090487 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000090487, Expressed in liver and 242 other tissues |
ExpressionAtlasi | A0A024R5Y1, baseline and differential |
Interactioni
Subunit structurei
Interacts with CD4.
Interacts with ALDH16A1.
ARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 87 – 159 | AB hydrolase-1InterPro annotationAdd BLAST | 73 |
Phylogenomic databases
HOGENOMi | CLU_052260_0_0_1 |
OMAi | SVDFMVE |
OrthoDBi | 818498at2759 |
PhylomeDBi | A0A024R5Y1 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000073, AB_hydrolase_1 IPR026151, Maspardin |
PANTHERi | PTHR15913, PTHR15913, 1 hit |
Pfami | View protein in Pfam PF00561, Abhydrolase_1, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R5Y1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGEIKVSPDY NWFRGTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP
60 70 80 90 100
PVSGTADVFF RQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL
110 120 130 140 150
DKVHLFGASL GGFLAQKFAE YTHKSPRVHS LILCNSFSDT SIFNQTWTAN
160 170 180 190 200
SFWLMPAFML KKIVLGNFSS GPVDPMMADA IDFMVDRLES LGQSELASRL
210 220 230 240 250
TLNCQNSYVE PHKIRDIPVT IMDVFDQSAL STEAKEEMYK LYPNARRAHL
260 270 280 290 300
KTGGNFPYLC RSAEVNLYVQ IHLLQFHGTK YAAIDPSMVS AEELEVQKGS
LGISQEEQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471082 Genomic DNA Translation: EAW77705.1 |
RefSeqi | NP_001121361.1, NM_001127889.4 NP_057714.1, NM_016630.6 XP_005254494.1, XM_005254437.4 XP_016877786.1, XM_017022297.1 XP_016877787.1, XM_017022298.1 |
Genome annotation databases
GeneIDi | 51324 |
KEGGi | hsa:51324 |
MANE-Selecti | ENST00000204566.7; ENSP00000204566.2; NM_016630.7; NP_057714.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471082 Genomic DNA Translation: EAW77705.1 |
RefSeqi | NP_001121361.1, NM_001127889.4 NP_057714.1, NM_016630.6 XP_005254494.1, XM_005254437.4 XP_016877786.1, XM_017022297.1 XP_016877787.1, XM_017022298.1 |
3D structure databases
SMRi | A0A024R5Y1 |
ModBasei | Search... |
Protein family/group databases
ESTHERi | human-SPG21, Maspardin-ACP33-SPG21_like |
Protocols and materials databases
Antibodypediai | 25890, 110 antibodies from 20 providers |
DNASUi | 51324 |
Genome annotation databases
GeneIDi | 51324 |
KEGGi | hsa:51324 |
MANE-Selecti | ENST00000204566.7; ENSP00000204566.2; NM_016630.7; NP_057714.1 |
Organism-specific databases
CTDi | 51324 |
VEuPathDBi | HostDB:ENSG00000090487 |
Phylogenomic databases
HOGENOMi | CLU_052260_0_0_1 |
OMAi | SVDFMVE |
OrthoDBi | 818498at2759 |
PhylomeDBi | A0A024R5Y1 |
Miscellaneous databases
BioGRID-ORCSi | 51324, 56 hits in 1083 CRISPR screens |
ChiTaRSi | SPG21, human |
GenomeRNAii | 51324 |
Gene expression databases
Bgeei | ENSG00000090487, Expressed in liver and 242 other tissues |
ExpressionAtlasi | A0A024R5Y1, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000073, AB_hydrolase_1 IPR026151, Maspardin |
PANTHERi | PTHR15913, PTHR15913, 1 hit |
Pfami | View protein in Pfam PF00561, Abhydrolase_1, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R5Y1_HUMAN | |
Accessioni | A0A024R5Y1Primary (citable) accession number: A0A024R5Y1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | May 25, 2022 | |
This is version 43 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |