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Entry version 44 (22 Apr 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Dmx-like 2, isoform CRA_c

Gene

DMXL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dmx-like 2, isoform CRA_cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMXL2Imported
ORF Names:hCG_1786381Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000104093.13

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104093 Expressed in intestine and 210 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2759 – 2979WD_REPEATS_REGIONInterPro annotationAdd BLAST221
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2896 – 2937WDPROSITE-ProRule annotationAdd BLAST42
Repeati2938 – 2979WDPROSITE-ProRule annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni417 – 480DisorderedSequence analysisAdd BLAST64
Regioni932 – 959DisorderedSequence analysisAdd BLAST28
Regioni1927 – 1952DisorderedSequence analysisAdd BLAST26
Regioni1999 – 2033DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2124 – 2151Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi433 – 474PolyampholyteSequence analysisAdd BLAST42
Compositional biasi1999 – 2013PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, WD repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1064 Eukaryota
ENOG410XPUM LUCA

Database of Orthologous Groups

More...
OrthoDBi
127808at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022033 Rav1p_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12234 Rav1p_C, 2 hits
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R5V2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLHQVLTGA VNPGDNCYSV GSVGDVPFTA YGSGCDIVIL ANDFECVQII
60 70 80 90 100
PGAKHGNIQV SCVECSNQQG RIAASYGNAV CIFEPLGINS HKRNCQLKCQ
110 120 130 140 150
WLKTGQFFLS SVTYNLAWDP QDNRLLTATD SIQLWAPPGD DILEEEEEID
160 170 180 190 200
NTVPPVLNDW KCVWQCKTSV SVHLMEWSPD GEYFATAGKD DCLLKVWYPM
210 220 230 240 250
TGWKSSIIPQ DHHEVKRRQS STQFSFVYLA HPRAVTGFSW RKTSKYMPRG
260 270 280 290 300
SVCNVLLTSC HDGVCRLWAE TLLPEDCLLG EQICETTTSS IASSLSHAGR
310 320 330 340 350
HKDRIQHALE TIHHLKNLRK GQRRSSVLVT HAELMPDQTA MHEVQRHISH
360 370 380 390 400
HANALCHFHI AASINPATDI PNVLVGTAFN VDDGNGGFVV HWLNNKEFHF
410 420 430 440 450
TSSTEVFMHQ LRKLSDKQVD HENDDADRED EEHSQEDRER GLHMKLDHDL
460 470 480 490 500
SLDRESEAGT GSSEHEDGER EGSPRTYSRL SVPMPLPTVL LDRKIETLLT
510 520 530 540 550
EWNKNPDMLF TIHPVDGTFL VWHVKYLDEY NPGIFRQVQV SFSSRIPVAF
560 570 580 590 600
PSGDASSLSK NIMMYACINA TKDSHHTLLH QEGMSVGSPH GSQPHSRSHS
610 620 630 640 650
THMNILAPTV MMISKHIDGS LNQWAVTFAD KSAFTTVLTV SHKFRYCGHR
660 670 680 690 700
FHLNDLACHS VLPLLLTSSH HNALLTPELD CQWDSDNKLS RLMDPVKHIK
710 720 730 740 750
GSSKQPLRNA ATRTFHDPNA IYSELILWRV DPIGPLSYTG GVSELARINS
760 770 780 790 800
LHTSAFSNVA WLPTLIPSYC LGTYCNSASA CFVASDGKNL RLYQAVVDAR
810 820 830 840 850
KLLDELSDPE SSKLIGEVFN IVSQQSTARP GCIIELDAIT NQCGSNTQLL
860 870 880 890 900
HVFQEDFIIG YKPHKEDMEK KETEIFFQPS QGYRPPPFSE KFFLVVIEKD
910 920 930 940 950
SNNNSILHMW HLHLKSVQAC LAKASEGASS ESLLSVPGQK NVDSSPETSP
960 970 980 990 1000
SVSPMPHSSS IANLQTASKL ILSSRLVYSQ PLDLPESVEV IRATPSAGHL
1010 1020 1030 1040 1050
SSSSIYPVCL APYLVVTTCS DNKVRFWKCC MEANPECNKS DEKEIYHWKR
1060 1070 1080 1090 1100
WPLMNDEGED NSSTVSIVGR PVAVSCSYTG RLAVAYKQPI HHNGFVSKEF
1110 1120 1130 1140 1150
SMHVCIFECE STGGSEWVLE QTIHLDDLVK VGSVLDSRVS VDSNLFVYSK
1160 1170 1180 1190 1200
SDALLSKDRY LIPNIKHLVH LDWVSKEDGS HILTVGVGAN IFMYGRLSGI
1210 1220 1230 1240 1250
VTEQTNSKDG VAVITLPLGG SIKQGVKSRW VLLRSIDLVS SVDGTPSLPV
1260 1270 1280 1290 1300
SLSWVRDGIL VVGMDCEMHV YAQWKHAVKF GDTEADSSNA EEAAMQDHST
1310 1320 1330 1340 1350
FKSNMLARKS VVEGTAISDD VFCSPTVIQD GGLFEAAHVL SPTLPQYHPT
1360 1370 1380 1390 1400
QLLELMDLGK VRRAKAILSH LVKCIAGEVA IVRDPDAGEG TKRHLSRTIS
1410 1420 1430 1440 1450
VSGSTAKETV TVGKDGTRDY TEIDSIPPLP LYALLAADQD TSYRISEEST
1460 1470 1480 1490 1500
KIPQSYEDQT VSQPEDQYSE LFQIQDIPTD DIDLEPEKRE NKSKVINLSQ
1510 1520 1530 1540 1550
YGPAYFGQEH ARVLSSHLMH SSLPGLTRLE QMFLVALADT VATTSTELDE
1560 1570 1580 1590 1600
SRDKSCSGRD TLDECGLRYL LAMRLHTCLL TSLPPLYRVQ LLHQGVSTCH
1610 1620 1630 1640 1650
FAWAFHSEAE EELINMIPAI QRGDPQWSEL RAMGIGWWVR NINTLRRCIE
1660 1670 1680 1690 1700
KVAKASFQRN NDALDAALFY LSMKKKAVVW GLFRSQHDEK MTTFFSHNFN
1710 1720 1730 1740 1750
EDRWRKAALK NAFSLLGKQR FEQSAAFFLL AGSLKDAIEV CLEKMEDIQL
1760 1770 1780 1790 1800
AMVIARLYES EFETSSTYIS ILNQKILGCQ KDGSGFSCKR LHPDPFLRSL
1810 1820 1830 1840 1850
AYWVMKDYTR ALDTLLEQTP KEDDEHQVII KSCNPVAFSF YNYLRTHPLL
1860 1870 1880 1890 1900
IRRNLASPEG TLATLGLKTE KNFVDKINLI ERKLFFTTAN AHFKVGCPVL
1910 1920 1930 1940 1950
ALEVLSKIPK VTKTSALSAK KDQPDFISHR MDDVPSHSKA LSDGNGSSGI
1960 1970 1980 1990 2000
EWSNVTSSQY DWSQPIVKVD EEPLNLDWGE DHDSALDEEE DDAVGLVMKS
2010 2020 2030 2040 2050
TDAREKDKQS DQKASDPNML LTPQEEDDPE GDTEVDVIAE QLKFRACLKI
2060 2070 2080 2090 2100
LMTELRTLAT GYEVDGGKLR FQLYNWLEKE IAALHEICNH ESVIKEYSSK
2110 2120 2130 2140 2150
TYSKVESDLL DQEEMVDKPD IGSYERHQIE RRRLQAKREH AERRKSWLQK
2160 2170 2180 2190 2200
NQDLLRVFLS YCSLHGAQGG GLASVRMELK FLLQESQQET TVKQLQSPLP
2210 2220 2230 2240 2250
LPTTLPLLSA SIASTKTVIA NPVLYLNNHI HDILYTIVQM KTPPHPSIED
2260 2270 2280 2290 2300
VKVHTLHSLA ASLSASIYQA LCDSHSYSQT EGNQFTGMAY QGLLLSDRRR
2310 2320 2330 2340 2350
LRTESIEEHA TPNSSPAQWP GVSSLINLLS SAQDEDQPKL NILLCEAVVA
2360 2370 2380 2390 2400
VYLSLLIHAL ATNSSSELFR LAAHPLNNRM WAAVFGGGVK LVVKPRRQSE
2410 2420 2430 2440 2450
NISAPPVLSE DIDKHRRRFN MRMLVPGRPV KDATPPPVPA ERPSYKEKFI
2460 2470 2480 2490 2500
PPELSMWDYF VAKPFLPLSD SGVIYDSDES IHSDEEDDAF FSDTQIQEHQ
2510 2520 2530 2540 2550
DPNSYSWALL HLTMVKLALH NVKNFFPIAG LEFSELPVTS PLGIAVIKNL
2560 2570 2580 2590 2600
ENWEQILQEK MDQFEGPPPN YINTYPTDLS VGAGPAILRN KAMLEPENTP
2610 2620 2630 2640 2650
FKSRDSSAFP VKRLWHFLVK QEVLQETFIR YIFTKKRKQS EVEADLGYPG
2660 2670 2680 2690 2700
GKAKVIHKES DMIMAFSVNK ANCNEIVLAS THDVQELDVT SLLACQSYIW
2710 2720 2730 2740 2750
IGEEYDRESK SSDDVDYRGS TTTLYQPSAT SYSASQVHPP SSLPWLGTGQ
2760 2770 2780 2790 2800
TSTGASVLMK RNLHNVKRMT SHPVHQYYLT GAQDGSVRMF EWTRPQQLVC
2810 2820 2830 2840 2850
FRQAGNARVT RLYFNSQGNK CGVADGEGFL SIWQVNQTAS NPKPYMSWQC
2860 2870 2880 2890 2900
HSKATSDFAF ITSSSLVATS GHSNDNRNVC LWDTLISPGN SLIHGFTCHD
2910 2920 2930 2940 2950
HGATVLQYAP KQQLLISGGR KGHVCIFDIR QRQLIHTFQA HDSAIKALAL
2960 2970 2980 2990 3000
DPYEEYFTTG SAEGNIKVWR LTGHGLIHSF KSEHAKQSIF RNIGAGVMQI
3010 3020 3030
DIIQGNRLFS CGADGTLKTR VLPNAFNIPN RILDIL
Length:3,036
Mass (Da):339,641
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25E9B1D05C69882C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471082 Genomic DNA Translation: EAW77422.1
CH471082 Genomic DNA Translation: EAW77423.1

NCBI Reference Sequences

More...
RefSeqi
NP_056078.2, NM_015263.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23312

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23312

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471082 Genomic DNA Translation: EAW77422.1
CH471082 Genomic DNA Translation: EAW77423.1
RefSeqiNP_056078.2, NM_015263.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51332 43 antibodies

Genome annotation databases

GeneIDi23312
KEGGihsa:23312

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23312
EuPathDBiHostDB:ENSG00000104093.13

Phylogenomic databases

eggNOGiKOG1064 Eukaryota
ENOG410XPUM LUCA
OrthoDBi127808at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DMXL2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23312

Gene expression databases

BgeeiENSG00000104093 Expressed in intestine and 210 other tissues

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR022033 Rav1p_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12234 Rav1p_C, 2 hits
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 13 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R5V2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R5V2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: April 22, 2020
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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