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UniProtKB - A0A024R5Q7 (A0A024R5Q7_HUMAN)
Protein
Adenylosuccinate synthetase isozyme 2
Gene
ADSS
Organism
Homo sapiens (Human)
Status
Functioni
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
UniRule annotationPlays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
ARBA annotationPlays an important role in the de novo pathway of purine nucleotide biosynthesis.
UniRule annotationCatalytic activityi
- EC:6.3.4.4UniRule annotation
Cofactori
Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation
: AMP biosynthesis via de novo pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes AMP from IMP.UniRule annotation This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 40 | Proton acceptorUniRule annotation | 1 | |
Metal bindingi | 40 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 40 | SubstrateUniRule annotation | 1 | |
Metal bindingi | 67 | Magnesium; via carbonyl oxygenUniRule annotation | 1 | |
Active sitei | 68 | Proton donorUniRule annotation | 1 | |
Binding sitei | 162 | IMPUniRule annotation | 1 | |
Active sitei | 173 | PROSITE-ProRule annotation | 1 | |
Binding sitei | 176 | IMP; shared with dimeric partnerUniRule annotation | 1 | |
Binding sitei | 255 | IMPUniRule annotation | 1 | |
Binding sitei | 270 | IMPUniRule annotation | 1 | |
Binding sitei | 334 | IMPUniRule annotation | 1 | |
Binding sitei | 336 | GTPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 39 – 45 | GTPUniRule annotation | 7 | |
Nucleotide bindingi | 67 – 69 | GTPUniRule annotation | 3 | |
Nucleotide bindingi | 362 – 364 | GTPUniRule annotation | 3 | |
Nucleotide bindingi | 444 – 447 | GTPUniRule annotation | 4 |
GO - Molecular functioni
- adenylosuccinate synthase activity Source: UniProtKB-UniRule
- GTP binding Source: UniProtKB-UniRule
- magnesium ion binding Source: UniProtKB-UniRule
GO - Biological processi
- 'de novo' AMP biosynthetic process Source: UniProtKB-UniPathway
- aspartate metabolic process Source: Ensembl
- cellular response to electrical stimulus Source: Ensembl
- IMP metabolic process Source: Ensembl
- response to ammonium ion Source: Ensembl
- response to purine-containing compound Source: Ensembl
Keywordsi
Molecular function | LigaseUniRule annotationARBA annotation |
Biological process | Purine biosynthesisUniRule annotationARBA annotation |
Ligand | GTP-bindingUniRule annotationARBA annotation, MagnesiumUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00075;UER00335 |
Names & Taxonomyi
Protein namesi | Recommended name: Adenylosuccinate synthetase isozyme 2UniRule annotation (EC:6.3.4.4UniRule annotation)Short name: AMPSase 2UniRule annotation Short name: AdSS 2UniRule annotation Alternative name(s): Adenylosuccinate synthetase, acidic isozymeUniRule annotation Adenylosuccinate synthetase, liver isozymeUniRule annotation Short name: L-type adenylosuccinate synthetaseUniRule annotation IMP--aspartate ligase 2UniRule annotation |
Gene namesi | Name:ADSSUniRule annotationImported Synonyms:ADSS2UniRule annotation ORF Names:hCG_15389Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000035687 |
Subcellular locationi
Mitochondrion
- Mitochondrion ARBA annotation
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotation, MitochondrionARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000035687, Expressed in corpus callosum and 239 other tissues |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationARBA annotationStructurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 40 – 43 | IMP bindingUniRule annotation | 4 | |
Regioni | 65 – 68 | IMP bindingUniRule annotation | 4 | |
Regioni | 330 – 336 | Substrate bindingUniRule annotation | 7 |
Sequence similaritiesi
Belongs to the adenylosuccinate synthetase family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_029848_3_0_1 |
OMAi | FHHAKPI |
OrthoDBi | 1276527at2759 |
Family and domain databases
CDDi | cd03108, AdSS, 1 hit |
Gene3Di | 1.10.300.10, 1 hit 3.40.440.10, 1 hit 3.90.170.10, 1 hit |
HAMAPi | MF_00011, Adenylosucc_synth, 1 hit MF_03127, Adenylosucc_synth_vert_acid, 1 hit |
InterProi | View protein in InterPro IPR018220, Adenylosuccin_syn_GTP-bd IPR033128, Adenylosuccin_syn_Lys_AS IPR042109, Adenylosuccinate_synth_dom1 IPR042110, Adenylosuccinate_synth_dom2 IPR042111, Adenylosuccinate_synth_dom3 IPR001114, Adenylosuccinate_synthetase IPR027529, AdSS_2_vert IPR027417, P-loop_NTPase |
PANTHERi | PTHR11846, PTHR11846, 1 hit |
Pfami | View protein in Pfam PF00709, Adenylsucc_synt, 1 hit |
SMARTi | View protein in SMART SM00788, Adenylsucc_synt, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00184, purA, 1 hit |
PROSITEi | View protein in PROSITE PS01266, ADENYLOSUCCIN_SYN_1, 1 hit PS00513, ADENYLOSUCCIN_SYN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R5Q7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFAETYPAA SSLPNGDCGR PRARPGGNRV TVVLGAQWGD EGKGKVVDLL
60 70 80 90 100
AQDADIVCRC QGGNNAGHTV VVDSVEYDFH LLPSGIINPN VTAFIGNGVV
110 120 130 140 150
IHLPGLFEEA EKNVQKGKGL EGWEKRLIIS DRAHIVFDFH QAADGIQEQQ
160 170 180 190 200
RQEQAGKNLG TTKKGIGPVY SSKAARSGLR MCDLVSDFDG FSERFKVLAN
210 220 230 240 250
QYKSIYPTLE IDIEGELQKL KGYMEKIKPM VRDGVYFLYE ALHGPPKKIL
260 270 280 290 300
VEGANAALLD IDFGTYPFVT SSNCTVGGVC TGLGMPPQNV GEVYGVVKAY
310 320 330 340 350
TTRVGIGAFP TEQDNEIGEL LQTRGREFGV TTGRKRRCGW LDLVLLKYAH
360 370 380 390 400
MINGFTALAL TKLDILDMFT EIKVGVAYKL DGEIIPHIPA NQEVLNKVEV
410 420 430 440 450
QYKTLPGWNT DISNARAFKE LPVNAQNYVR FIEDELQIPV KWIGVGKSRE
SMIQLF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ900992 mRNA Translation: ADO22509.1 CH471148 Genomic DNA Translation: EAW77103.1 |
RefSeqi | NP_001117.2, NM_001126.3 |
Genome annotation databases
GeneIDi | 159 |
KEGGi | hsa:159 |
MANE-Selecti | ENST00000366535.4; ENSP00000355493.3; NM_001126.5; NP_001117.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ900992 mRNA Translation: ADO22509.1 CH471148 Genomic DNA Translation: EAW77103.1 |
RefSeqi | NP_001117.2, NM_001126.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 20829, 153 antibodies from 23 providers |
DNASUi | 159 |
Genome annotation databases
GeneIDi | 159 |
KEGGi | hsa:159 |
MANE-Selecti | ENST00000366535.4; ENSP00000355493.3; NM_001126.5; NP_001117.2 |
Organism-specific databases
CTDi | 159 |
VEuPathDBi | HostDB:ENSG00000035687 |
Phylogenomic databases
HOGENOMi | CLU_029848_3_0_1 |
OMAi | FHHAKPI |
OrthoDBi | 1276527at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00075;UER00335 |
Miscellaneous databases
BioGRID-ORCSi | 159, 334 hits in 1071 CRISPR screens |
ChiTaRSi | ADSS, human |
GenomeRNAii | 159 |
Gene expression databases
Bgeei | ENSG00000035687, Expressed in corpus callosum and 239 other tissues |
Family and domain databases
CDDi | cd03108, AdSS, 1 hit |
Gene3Di | 1.10.300.10, 1 hit 3.40.440.10, 1 hit 3.90.170.10, 1 hit |
HAMAPi | MF_00011, Adenylosucc_synth, 1 hit MF_03127, Adenylosucc_synth_vert_acid, 1 hit |
InterProi | View protein in InterPro IPR018220, Adenylosuccin_syn_GTP-bd IPR033128, Adenylosuccin_syn_Lys_AS IPR042109, Adenylosuccinate_synth_dom1 IPR042110, Adenylosuccinate_synth_dom2 IPR042111, Adenylosuccinate_synth_dom3 IPR001114, Adenylosuccinate_synthetase IPR027529, AdSS_2_vert IPR027417, P-loop_NTPase |
PANTHERi | PTHR11846, PTHR11846, 1 hit |
Pfami | View protein in Pfam PF00709, Adenylsucc_synt, 1 hit |
SMARTi | View protein in SMART SM00788, Adenylsucc_synt, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00184, purA, 1 hit |
PROSITEi | View protein in PROSITE PS01266, ADENYLOSUCCIN_SYN_1, 1 hit PS00513, ADENYLOSUCCIN_SYN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R5Q7_HUMAN | |
Accessioni | A0A024R5Q7Primary (citable) accession number: A0A024R5Q7 Secondary accession number(s): A0A384MEI4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | May 25, 2022 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |