UniProtKB - A0A024R5P0 (A0A024R5P0_HUMAN)
Protein
Non-specific serine/threonine protein kinase
Gene
PAK1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: InterPro
Keywordsi
Molecular function | Allosteric enzymeARBA annotation, KinaseImported, Transferase |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:PAK1Imported ORF Names:hCG_41873Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000149269.9 |
Subcellular locationi
Other locations
- Cytoplasm ARBA annotation
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000149269, Expressed in middle temporal gyrus and 218 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 75 – 88 | CRIBInterPro annotationAdd BLAST | 14 | |
Domaini | 270 – 521 | Protein kinaseInterPro annotationAdd BLAST | 252 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 77 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 159 – 198 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 211 – 251 | DisorderedSequence analysisAdd BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 42 – 77 | PolyampholyteSequence analysisAdd BLAST | 36 | |
Compositional biasi | 216 – 236 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 237 – 251 | PolyampholyteSequence analysisAdd BLAST | 15 |
Phylogenomic databases
OrthoDBi | 757766at2759 |
Family and domain databases
CDDi | cd01093, CRIB_PAK_like, 1 hit |
Gene3Di | 3.90.810.10, 1 hit |
InterProi | View protein in InterPro IPR000095, CRIB_dom IPR036936, CRIB_dom_sf IPR011009, Kinase-like_dom_sf IPR033923, PAK_BD IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00786, PBD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R5P0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNNGLDIQD KPPAPPMRNT STMIGAGSKD AGTLNHGSKP LPPNPEEKKK
60 70 80 90 100
KDRFYRSILP GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP
110 120 130 140 150
EQWARLLQTS NITKSEQKKN PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA
160 170 180 190 200
EDYNSSNALN VKAVSETPAV PPVSEDEDDD DDDATPPPVI APRPEHTKSV
210 220 230 240 250
YTRSVIEPLP VTPTRDVATS PISPTENNTT PPDALTRNTE KQKKKPKMSD
260 270 280 290 300
EEILEKLRSI VSVGDPKKKY TRFEKIGQGA SGTVYTAMDV ATGQEVAIKQ
310 320 330 340 350
MNLQQQPKKE LIINEILVMR ENKNPNIVNY LDSYLVGDEL WVVMEYLAGG
360 370 380 390 400
SLTDVVTETC MDEGQIAAVC RECLQALEFL HSNQVIHRDI KSDNILLGMD
410 420 430 440 450
GSVKLTDFGF CAQITPEQSK RSTMVGTPYW MAPEVVTRKA YGPKVDIWSL
460 470 480 490 500
GIMAIEMIEG EPPYLNENPL RALYLIATNG TPELQNPEKL SAIFRDFLNR
510 520 530 540
CLEMDVEKRG SAKELLQHQF LKIAKPLSSL TPLIAAAKEA TKNNH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471076 Genomic DNA Translation: EAW75026.1 CH471076 Genomic DNA Translation: EAW75027.1 CH471076 Genomic DNA Translation: EAW75029.1 |
RefSeqi | NP_002567.3, NM_002576.4 XP_016873335.1, XM_017017846.1 XP_016873336.1, XM_017017847.1 XP_016873337.1, XM_017017848.1 XP_016873338.1, XM_017017849.1 XP_016873339.1, XM_017017850.1 |
Genome annotation databases
GeneIDi | 5058 |
KEGGi | hsa:5058 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471076 Genomic DNA Translation: EAW75026.1 CH471076 Genomic DNA Translation: EAW75027.1 CH471076 Genomic DNA Translation: EAW75029.1 |
RefSeqi | NP_002567.3, NM_002576.4 XP_016873335.1, XM_017017846.1 XP_016873336.1, XM_017017847.1 XP_016873337.1, XM_017017848.1 XP_016873338.1, XM_017017849.1 XP_016873339.1, XM_017017850.1 |
3D structure databases
SMRi | A0A024R5P0 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024R5P0 |
Protocols and materials databases
Antibodypediai | 1132, 1365 antibodies |
Genome annotation databases
GeneIDi | 5058 |
KEGGi | hsa:5058 |
Organism-specific databases
CTDi | 5058 |
EuPathDBi | HostDB:ENSG00000149269.9 |
Phylogenomic databases
OrthoDBi | 757766at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5058, 14 hits in 877 CRISPR screens |
ChiTaRSi | PAK1, human |
GenomeRNAii | 5058 |
Gene expression databases
Bgeei | ENSG00000149269, Expressed in middle temporal gyrus and 218 other tissues |
Family and domain databases
CDDi | cd01093, CRIB_PAK_like, 1 hit |
Gene3Di | 3.90.810.10, 1 hit |
InterProi | View protein in InterPro IPR000095, CRIB_dom IPR036936, CRIB_dom_sf IPR011009, Kinase-like_dom_sf IPR033923, PAK_BD IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00786, PBD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R5P0_HUMAN | |
Accessioni | A0A024R5P0Primary (citable) accession number: A0A024R5P0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |