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UniProtKB - A0A024R5M9 (A0A024R5M9_HUMAN)

Entry version 54 (10 Feb 2021)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Nuclear mitotic apparatus protein 1, isoform CRA_a

Gene

NUMA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear mitotic apparatus protein 1, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUMA1Imported
ORF Names:hCG_2017131Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000137497.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137497, Expressed in right ovary and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A024R5M9, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A024R5M9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni549 – 593DisorderedSequence analysisAdd BLAST45
Regioni746 – 766DisorderedSequence analysisAdd BLAST21
Regioni926 – 958DisorderedSequence analysisAdd BLAST33
Regioni988 – 1013DisorderedSequence analysisAdd BLAST26
Regioni1090 – 1225DisorderedSequence analysisAdd BLAST136
Regioni1275 – 1296DisorderedSequence analysisAdd BLAST22
Regioni1720 – 1747DisorderedSequence analysisAdd BLAST28
Regioni1812 – 1887DisorderedSequence analysisAdd BLAST76
Regioni1941 – 2101DisorderedSequence analysisAdd BLAST161

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili216 – 250Sequence analysisAdd BLAST35
Coiled coili278 – 319Sequence analysisAdd BLAST42
Coiled coili327 – 400Sequence analysisAdd BLAST74
Coiled coili415 – 449Sequence analysisAdd BLAST35
Coiled coili468 – 491Sequence analysisAdd BLAST24
Coiled coili789 – 823Sequence analysisAdd BLAST35
Coiled coili828 – 862Sequence analysisAdd BLAST35
Coiled coili867 – 922Sequence analysisAdd BLAST56
Coiled coili1367 – 1405Sequence analysisAdd BLAST39
Coiled coili1409 – 1443Sequence analysisAdd BLAST35
Coiled coili1462 – 1511Sequence analysisAdd BLAST50
Coiled coili1516 – 1550Sequence analysisAdd BLAST35
Coiled coili1558 – 1679Sequence analysisAdd BLAST122

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi549 – 564PolarSequence analysisAdd BLAST16
Compositional biasi565 – 593PolyampholyteSequence analysisAdd BLAST29
Compositional biasi926 – 953PolyampholyteSequence analysisAdd BLAST28
Compositional biasi997 – 1013PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1090 – 1104PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1144 – 1161PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1195 – 1225PolyampholyteSequence analysisAdd BLAST31
Compositional biasi1720 – 1742PolarSequence analysisAdd BLAST23
Compositional biasi1816 – 1848PolarSequence analysisAdd BLAST33
Compositional biasi1859 – 1881PolarSequence analysisAdd BLAST23
Compositional biasi1950 – 1973PolarSequence analysisAdd BLAST24
Compositional biasi2000 – 2014PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2015 – 2044PolarSequence analysisAdd BLAST30
Compositional biasi2059 – 2086PolarSequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		524033at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026650, NUMA1

The PANTHER Classification System

More...PANTHERi		PTHR18902:SF24, PTHR18902:SF24, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R5M9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLHATRGAA LLSWVNSLHV ADPVEAVLQL QDCSIFIKII DRIHGTEEGQ 
        60         70         80         90        100
QILKQPVSER LDFVCSFLQK NRKHPSSPEC LVSAQKVLEG SELELAKMTM 
       110        120        130        140        150
LLLYHSTMSS KSPRDWEQFE YKIQAELAVI LKFVLDHEDG LNLNEDLENF 
       160        170        180        190        200
LQKAPVPSTC SSTFPEELSP PSHQAKREIR FLELQKVASS SSGNNFLSGS 
       210        220        230        240        250
PASPMGDILQ TPQFQMRRLK KQLADERSNR DELELELAEN RKLLTEKDAQ 
       260        270        280        290        300
IAMMQQRIDR LALLNEKQAA SPLEPKELEE LRDKNESLTM RLHETLKQCQ 
       310        320        330        340        350
DLKTEKSQMD RKINQLSEEN GDLSFKLREF ASHLQQLQDA LNELTEEHSK 
       360        370        380        390        400
ATQEWLEKQA QLEKELSAAL QDKKCLEEKN EILQGKLSQL EEHLSQLQDN 
       410        420        430        440        450
PPQEKGEVLG DVLQLETLKQ EAATLAANNT QLQARVEMLE TERGQQEAKL 
       460        470        480        490        500
LAERGHFEEE KQQLSSLITD LQSSISNLSQ AKEELEQASQ AHGARLTAQV 
       510        520        530        540        550
ASLTSELTTL NATIQQQDQE LAGLKQQAKE KQAQLAQTLQ QQEQASQGLR 
       560        570        580        590        600
HQVEQLSSSL KQKEQQLKEV AEKQEATRQD HAQQLATAAE EREASLRERD 
       610        620        630        640        650
AALKQLEALE KEKAAKLEIL QQQLQVANEA RDSAQTSVTQ AQREKAELSR 
       660        670        680        690        700
KVEELQACVE TARQEQHEAQ AQVAELELQL RSEQQKATEK ERVAQEKDQL 
       710        720        730        740        750
QEQLQALKES LKVTKGSLEE EKRRAADALE EQQRCISELK AETRSLVEQH 
       760        770        780        790        800
KRERKELEEE RAGRKGLEAR LQQLGEAHQA ETEVLRRELA EAMAAQHTAE 
       810        820        830        840        850
SECEQLVKEV AAWRERYEDS QQEEAQYGAM FQEQLMTLKE ECEKARQELQ 
       860        870        880        890        900
EAKEKVAGIE SHSELQISRQ QNELAELHAN LARALQQVQE KEVRAQKLAD 
       910        920        930        940        950
DLSTLQEKMA ATSKEVARLE TLVRKAGEQQ ETASRELVKE PARAGDRQPE 
       960        970        980        990       1000
WLEEQQGRQF CSTQAALQAM EREAEQMGNE LERLRAALME SQGQQQEERG 
      1010       1020       1030       1040       1050
QQEREVARLT QERGRAQADL ALEKAARAEL EMRLQNALNE QRVEFATLQE 
      1060       1070       1080       1090       1100
ALAHALTEKE GKDQELAKLR GLEAAQIKEL EELRQTVKQL KEQLAKKEKE 
      1110       1120       1130       1140       1150
HASGSGAQSE AAGRTEPTGP KLEALRAEVS KLEQQCQKQQ EQADSLERSL 
      1160       1170       1180       1190       1200
EAERASRAER DSALETLQGQ LEEKAQELGH SQSALASAQR ELAAFRTKVQ 
      1210       1220       1230       1240       1250
DHSKAEDEWK AQVARGRQEA ERKNSLISSL EEEVSILNRQ VLEKEGESKE 
      1260       1270       1280       1290       1300
LKRLVMAESE KSQKLEERLR LLQAETASNS ARAAERSSAL REEVQSLREE 
      1310       1320       1330       1340       1350
AEKQRVASEN LRQELTSQAE RAEELGQELK AWQEKFFQKE QALSTLQLEH 
      1360       1370       1380       1390       1400
TSTQALVSEL LPAKHLCQQL QAEQAAAEKR HREELEQSKQ AAGGLRAELL 
      1410       1420       1430       1440       1450
RAQRELGELI PLRQKVAEQE RTAQQLRAEK ASYAEQLSML KKAHGLLAEE 
      1460       1470       1480       1490       1500
NRGLGERANL GRQFLEVELD QAREKYVQEL AAVRADAETR LAEVQREAQS 
      1510       1520       1530       1540       1550
TARELEVMTA KYEGAKVKVL EERQRFQEER QKLTAQVEEL SKKLADSDQA 
      1560       1570       1580       1590       1600
SKVQQQKLKA VQAQGGESQQ EAQRLQAQLN ELQAQLSQKE QAAEHYKLQM 
      1610       1620       1630       1640       1650
EKAKTHYDAK KQQNQELQEQ LRSLEQLQKE NKELRAEAER LGHELQQAGL 
      1660       1670       1680       1690       1700
KTKEAEQTCR HLTAQVRSLE AQVAHADQQL RDLGKFQVAT DALKSREPQA 
      1710       1720       1730       1740       1750
KPQLDLSIDS LDLSCEEGTP LSITSKLPRT QPDGTSVPGE PASPISQRLP 
      1760       1770       1780       1790       1800
PKVESLESLY FTPIPARSQA PLESSLDSLG DVFLDSGRKT RSARRRTTQI 
      1810       1820       1830       1840       1850
INITMTKKLD VEEPDSANSS FYSTRSAPAS QASLRATSST QSLARLGSPD 
      1860       1870       1880       1890       1900
YGNSALLSLP GYRPTTRSSA RRSQAGVSSG APPGRNSFYM GTCQDEPEQL 
      1910       1920       1930       1940       1950
DDWNRIAELQ QRNRVCPPHL KTCYPLESRP SLSLGTITDE EMKTGDPQET 
      1960       1970       1980       1990       2000
LRRASMQPIQ IAEGTGITTR QQRKRVSLEP HQGPGTPESK KATSCFPRPM 
      2010       2020       2030       2040       2050
TPRDRHEGRK QSTTEAQKKA APASTKQADR RQSMAFSILN TPKKLGNSLL 
      2060       2070       2080       2090       2100
RRGASKKALS KASPNTRSGT RRSPRIATTT ASAATAAAIG ATPRAKGKAK 

H
Length:2,101
Mass (Da):236,516
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18D8C4A34409ADE9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH471076 Genomic DNA Translation: EAW74821.1
CH471076 Genomic DNA Translation: EAW74824.1

NCBI Reference Sequences

More...RefSeqi		NP_001273490.1, NM_001286561.1
XP_011543368.1, XM_011545066.1
XP_016873319.1, XM_017017830.1
XP_016873320.1, XM_017017831.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4926

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA Translation: EAW74821.1
CH471076 Genomic DNA Translation: EAW74824.1
RefSeqiNP_001273490.1, NM_001286561.1
XP_011543368.1, XM_011545066.1
XP_016873319.1, XM_017017830.1
XP_016873320.1, XM_017017831.1

3D structure databases

SMRiA0A024R5M9
ModBaseiSearch...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16895, 403 antibodies

Genome annotation databases

GeneIDi4926

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4926
VEuPathDBiHostDB:ENSG00000137497.17

Phylogenomic databases

OrthoDBi524033at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4926, 439 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NUMA1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4926

Gene expression databases

BgeeiENSG00000137497, Expressed in right ovary and 250 other tissues
ExpressionAtlasiA0A024R5M9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR026650, NUMA1
PANTHERiPTHR18902:SF24, PTHR18902:SF24, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R5M9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R5M9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: February 10, 2021
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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