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Protein

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit

Gene

PPP2R5B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunitUniRule annotation
Gene namesi
Name:PPP2R5BImported
ORF Names:hCG_23377Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000068971.13

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSG00000068971 Expressed in 214 organ(s), highest expression level in right hemisphere of cerebellum

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphatase 2A regulatory subunit.UniRule annotation

Phylogenomic databases

eggNOGiKOG2085 Eukaryota
ENOG410XQJW LUCA
KOiK11584
OMAiFIYEFEH
OrthoDBiEOG091G06HU

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002554 PP2A_B56
PANTHERiPTHR10257 PTHR10257, 1 hit
PfamiView protein in Pfam
PF01603 B56, 1 hit
PIRSFiPIRSF028043 PP2A_B56, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

A0A024R593-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METKLPPAST PTSPSSPGLS PVPPPDKVDG FSRRSLRRAR PRRSHSSSQF
60 70 80 90 100
RYQSNQQELT PLPLLKDVPA SELHELLSRK LAQCGVMFDF LDCVADLKGK
110 120 130 140 150
EVKRAALNEL VECVGSTRGV LIEPVYPDII RMISVNIFRT LPPSENPEFD
160 170 180 190 200
PEEDEPNLEP SWPHLQLVYE FFLRFLESPD FQPSVAKRYV DQKFVLMLLE
210 220 230 240 250
LFDSEDPRER EYLKTILHRV YGKFLGLRAY IRKQCNHIFL RFIYEFEHFN
260 270 280 290 300
GVAELLEILG SIINGFALPL KTEHKQFLVR VLIPLHSVKS LSVFHAQLAY
310 320 330 340 350
CVVQFLEKDA TLTEHVIRGL LKYWPKTCTQ KEVMFLGEME EILDVIEPSQ
360 370 380 390 400
FVKIQEPLFK QVARCVSSPH FQVAERALYF WNNEYILSLI EDNCHTVLPA
410 420 430 440 450
VFGTLYQVSK EHWNQTIVSL IYNVLKTFME MNGKLFDELT ASYKLEKQQE
460 470 480 490
QQKAQERQEL WQGLEELRLR RLQGTQGAKE APLQRLTPQV AASGGQS
Length:497
Mass (Da):57,393
Last modified:July 9, 2014 - v1
Checksum:i8BEF84F20A77982D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA Translation: EAW74324.1
CH471076 Genomic DNA Translation: EAW74325.1
RefSeqiNP_006235.1, NM_006244.3
UniGeneiHs.75199

Genome annotation databases

GeneIDi5526
KEGGihsa:5526

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA Translation: EAW74324.1
CH471076 Genomic DNA Translation: EAW74325.1
RefSeqiNP_006235.1, NM_006244.3
UniGeneiHs.75199

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5526
KEGGihsa:5526

Organism-specific databases

CTDi5526
EuPathDBiHostDB:ENSG00000068971.13

Phylogenomic databases

eggNOGiKOG2085 Eukaryota
ENOG410XQJW LUCA
KOiK11584
OMAiFIYEFEH
OrthoDBiEOG091G06HU

Miscellaneous databases

ChiTaRSiPPP2R5B human
GenomeRNAii5526

Gene expression databases

BgeeiENSG00000068971 Expressed in 214 organ(s), highest expression level in right hemisphere of cerebellum

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002554 PP2A_B56
PANTHERiPTHR10257 PTHR10257, 1 hit
PfamiView protein in Pfam
PF01603 B56, 1 hit
PIRSFiPIRSF028043 PP2A_B56, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R593_HUMAN
AccessioniPrimary (citable) accession number: A0A024R593
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 10, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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