UBE2M

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	111	Glycyl thioester intermediatePROSITE-ProRule annotation		1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-UniRule
transferase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of neuron apoptotic process Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	TransferaseSAAS annotation
Biological process	Ubl conjugation pathwayUniRule annotationSAAS annotation
Ligand	ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), isoform CRA_aImported
Gene namesⁱ	Name:UBE2MImported ORF Names:hCG_2045958Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130725.7

EuPathDBⁱ

HostDB:ENSG00000130725.7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000130725 Expressed in 208 organ(s), highest expression level in right frontal lobe

Bgeeⁱ

ENSG00000130725 Expressed in 208 organ(s), highest expression level in right frontal lobe

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	32 – 162	UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST		131

Sequence similaritiesⁱ

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG0420 Eukaryota ENOG410XS81 LUCA
KEGG Orthology (KO) More...KOⁱ	K10579
OMAⁱ	MIKIWSM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N8A

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00195 UBCc, 1 hit
Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR023313 UBQ-conjugating_AS IPR016135 UBQ-conjugating_enzyme/RWD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS00183 UBIQUITIN_CONJUGAT_1, 1 hit PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A024R4T4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCDIS 
        60         70         80         90        100
FSDPDDLLNF KLVICPDEGF YKSGKFVFSF KVGQGYPHDP PKVKCETMVY 
       110        120        130        140        150
HPNIDLEGNV CLNILREDWK PVLTINSIIY GLQYLFLEPN PEDPLNKEAA 
       160        170        180 
EVLQNNRRLF EQNVQRSMRG GYIGSTYFER CLK

Length:183

Mass (Da):20,900

Last modified:July 9, 2014 - v1

Checksum:ⁱE3C288CA6A98BC5C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471135 Genomic DNA Translation: EAW72612.1 CH471135 Genomic DNA Translation: EAW72613.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003960.1, NM_003969.3
UniGeneⁱ	Hs.406068

Genome annotation databases

GeneIDⁱ	9040
KEGGⁱ	hsa:9040

Protein	Similar proteins		Species	Score	Length	Source
A0A024R4T4	NEDD8-conjugating enzyme Ubc12	)	HUMAN		183	UniRef100_P61081
NEDD8-conjugating enzyme Ubc12		BOVIN		183
NEDD8-conjugating enzyme Ubc12		MOUSE		183
Uncharacterized protein (Fragment)		CEREH		181
NEDD8-conjugating enzyme Ubc12		MACMU		183
+35

Protein	Similar proteins		Species	Score	Length	Source
A0A024R4T4	NEDD8-conjugating enzyme Ubc12	)	HUMAN		183	UniRef90_P61081
NEDD8-conjugating enzyme Ubc12		BOVIN		183
NEDD8-conjugating enzyme Ubc12		MOUSE		183
Uncharacterized protein (Fragment)		CEREH		181
NEDD8-conjugating enzyme Ubc12		MACMU		183
+39

Protein	Similar proteins		Species	Score	Length	Source
A0A024R4T4	NEDD8-conjugating enzyme Ubc12	)	HUMAN		183	UniRef50_P61081
NEDD8-conjugating enzyme Ubc12		BOVIN		183
NEDD8-conjugating enzyme Ubc12		MOUSE		183
Uncharacterized protein (Fragment)		CEREH		181
NEDD8-conjugating enzyme Ubc12		MACMU		183
+39

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471135 Genomic DNA Translation: EAW72612.1 CH471135 Genomic DNA Translation: EAW72613.1
RefSeqⁱ	NP_003960.1, NM_003969.3
UniGeneⁱ	Hs.406068

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	9040
KEGGⁱ	hsa:9040

Organism-specific databases

CTDⁱ	9040
EuPathDBⁱ	HostDB:ENSG00000130725.7

Phylogenomic databases

eggNOGⁱ	KOG0420 Eukaryota ENOG410XS81 LUCA
KOⁱ	K10579
OMAⁱ	MIKIWSM
OrthoDBⁱ	EOG091G0N8A

Miscellaneous databases

ChiTaRSⁱ	UBE2M human
GenomeRNAiⁱ	9040

Gene expression databases

Bgeeⁱ	ENSG00000130725 Expressed in 208 organ(s), highest expression level in right frontal lobe

Bgeeⁱ

ENSG00000130725 Expressed in 208 organ(s), highest expression level in right frontal lobe

Family and domain databases

CDDⁱ	cd00195 UBCc, 1 hit
Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR023313 UBQ-conjugating_AS IPR016135 UBQ-conjugating_enzyme/RWD
Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS00183 UBIQUITIN_CONJUGAT_1, 1 hit PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A024R4T4_HUMAN
Accessionⁱ	A0A024R4T4Primary (citable) accession number: A0A024R4T4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 9, 2014
	Last sequence update:	July 9, 2014
	Last modified:	October 10, 2018
	This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - A0A024R4T4 (A0A024R4T4_HUMAN)

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Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), isoform CRA_a

Select a section on the left to see content.

Functionⁱ

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

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UniProtKB - A0A024R4T4 (A0A024R4T4_HUMAN)

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Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), isoform CRA_a

UBE2M

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Expressionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ