UniProtKB - A0A024R4T4 (A0A024R4T4_HUMAN)
Protein
Submitted name:
Epididymis secretory sperm binding protein
Gene
UBE2M
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 111 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- transferase activity Source: UniProtKB-KW
GO - Biological processi
- positive regulation of neuron apoptotic process Source: Ensembl
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Epididymis secretory sperm binding proteinImportedSubmitted name: Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), isoform CRA_aImported |
Gene namesi | Name:UBE2MImported ORF Names:hCG_2045958Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000130725.7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130725, Expressed in superior frontal gyrus and 221 other tissues |
ExpressionAtlasi | A0A024R4T4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 162 | UBC coreInterPro annotationAdd BLAST | 131 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | PolyampholyteSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the ubiquitin-conjugating enzyme family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_030988_6_0_1 |
OMAi | NTNYPHE |
OrthoDBi | 1302735at2759 |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBIQUITIN_CONJUGAT_1, 1 hit PS50127, UBIQUITIN_CONJUGAT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024R4T4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCDIS
60 70 80 90 100
FSDPDDLLNF KLVICPDEGF YKSGKFVFSF KVGQGYPHDP PKVKCETMVY
110 120 130 140 150
HPNIDLEGNV CLNILREDWK PVLTINSIIY GLQYLFLEPN PEDPLNKEAA
160 170 180
EVLQNNRRLF EQNVQRSMRG GYIGSTYFER CLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ891447 mRNA Translation: ADO22309.1 CH471135 Genomic DNA Translation: EAW72612.1 CH471135 Genomic DNA Translation: EAW72613.1 |
RefSeqi | NP_003960.1, NM_003969.3 |
Genome annotation databases
GeneIDi | 9040 |
KEGGi | hsa:9040 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ891447 mRNA Translation: ADO22309.1 CH471135 Genomic DNA Translation: EAW72612.1 CH471135 Genomic DNA Translation: EAW72613.1 |
RefSeqi | NP_003960.1, NM_003969.3 |
3D structure databases
SMRi | A0A024R4T4 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 3333, 191 antibodies |
Genome annotation databases
GeneIDi | 9040 |
KEGGi | hsa:9040 |
Organism-specific databases
CTDi | 9040 |
EuPathDBi | HostDB:ENSG00000130725.7 |
Phylogenomic databases
HOGENOMi | CLU_030988_6_0_1 |
OMAi | NTNYPHE |
OrthoDBi | 1302735at2759 |
Miscellaneous databases
BioGRID-ORCSi | 9040, 674 hits in 827 CRISPR screens |
ChiTaRSi | UBE2M, human |
GenomeRNAii | 9040 |
Gene expression databases
Bgeei | ENSG00000130725, Expressed in superior frontal gyrus and 221 other tissues |
ExpressionAtlasi | A0A024R4T4, baseline and differential |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBIQUITIN_CONJUGAT_1, 1 hit PS50127, UBIQUITIN_CONJUGAT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024R4T4_HUMAN | |
Accessioni | A0A024R4T4Primary (citable) accession number: A0A024R4T4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |