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Entry version 38 (07 Apr 2021)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

HCG1640809, isoform CRA_b

Gene

hCG_1640809

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HCG1640809, isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:hCG_1640809Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000179820.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 61HelicalSequence analysisAdd BLAST24
Transmembranei67 – 89HelicalSequence analysisAdd BLAST23
Transmembranei101 – 124HelicalSequence analysisAdd BLAST24
Transmembranei136 – 153HelicalSequence analysisAdd BLAST18
Transmembranei165 – 190HelicalSequence analysisAdd BLAST26
Transmembranei202 – 226HelicalSequence analysisAdd BLAST25
Transmembranei238 – 261HelicalSequence analysisAdd BLAST24
Transmembranei294 – 320HelicalSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179820, Expressed in layer of synovial tissue and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A0A024R4N0, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 163MARVELInterPro annotationAdd BLAST133
Domaini168 – 319MARVELInterPro annotationAdd BLAST152

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

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OMAi
TTYVQFM

Database of Orthologous Groups

More...
OrthoDBi
1056604at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
A0A024R4N0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008253, Marvel

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01284, MARVEL, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51225, MARVEL, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024R4N0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVTVTRTTI TTTTTSSSGL GSPMIVGSPR ALTQPLGLLR LLQLVSTCVA
60 70 80 90 100
FSLVASVGAW TGSMGNWSMF TWCFCFSVTL IILIVELCGL QARFPLSWRN
110 120 130 140 150
FPITFACYAA LFCLSASIIY PTTYVQFLSH GRSRDHAIAA TFFSCIACVA
160 170 180 190 200
YATEVAWTRA RPGEITGYMA TVPGLLKVLE TFVACIIFAF ISDPNLYQHQ
210 220 230 240 250
PALEWCVAVY AICFILAAIA ILLNLGECTN VLPIPFPSFL SGLALLSVLL
260 270 280 290 300
YATALVLWPL YQFDEKYGGQ PRRSRDVSCS RSHAYYVCAW DRRLAVAILT
310 320
AINLLAYVAD LVHSAHLVFV KV
Length:322
Mass (Da):35,274
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA92142CC63625A4E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CH471135 Genomic DNA Translation: EAW72160.1

NCBI Reference Sequences

More...
RefSeqi
NP_001018654.1, NM_001020818.2
NP_001018655.1, NM_001020819.2
NP_001018656.1, NM_001020820.2
NP_001018657.1, NM_001020821.2
NP_001277117.1, NM_001290188.1
NP_001277118.1, NM_001290189.1
NP_001277119.1, NM_001290190.1
NP_001277120.1, NM_001290191.1
NP_001277121.1, NM_001290192.1
NP_001277122.1, NM_001290193.1
NP_001277123.1, NM_001290194.1
NP_612382.1, NM_138373.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
91663

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:91663

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471135 Genomic DNA Translation: EAW72160.1
RefSeqiNP_001018654.1, NM_001020818.2
NP_001018655.1, NM_001020819.2
NP_001018656.1, NM_001020820.2
NP_001018657.1, NM_001020821.2
NP_001277117.1, NM_001290188.1
NP_001277118.1, NM_001290189.1
NP_001277119.1, NM_001290190.1
NP_001277120.1, NM_001290191.1
NP_001277121.1, NM_001290192.1
NP_001277122.1, NM_001290193.1
NP_001277123.1, NM_001290194.1
NP_612382.1, NM_138373.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
19206, 216 antibodies

The DNASU plasmid repository

More...
DNASUi
91663

Genome annotation databases

GeneIDi91663
KEGGihsa:91663

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91663
VEuPathDBiHostDB:ENSG00000179820.15

Phylogenomic databases

OMAiTTYVQFM
OrthoDBi1056604at2759
PhylomeDBiA0A024R4N0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
91663, 190 hits in 994 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
91663

Gene expression databases

BgeeiENSG00000179820, Expressed in layer of synovial tissue and 226 other tissues
ExpressionAtlasiA0A024R4N0, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR008253, Marvel
PfamiView protein in Pfam
PF01284, MARVEL, 2 hits
PROSITEiView protein in PROSITE
PS51225, MARVEL, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024R4N0_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024R4N0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: April 7, 2021
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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